Conserved Protein Domain Family
7tmA_OR52A-like

?
cd15955: 7tmA_OR52A-like 
olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
?
PSSM-Id: 320621
View PSSM: cd15955
Aligned: 6 rows
Threshold Bit Score: 397.987
Threshold Setting Gi: 47576405
Created: 17-Dec-2014
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 74762730   27 CWIGIPFSAMYLIGVIGNSLILVIIKYENSLHiPMYIFLAMLAATDIALNTCILPKMLGIFWfhlPEISfdaCLFQMWLI 106
gi 585658434  27 HWIGIPFFISFILAVFGNGLLITVIRTERSLHePMYIFLSVLAATDLGLTLCITPKMLAIFWlqsREIHfdsCLIQMYFT 106
gi 47576405   28 FWIGFPFFTVCLVAVLGNVVLLIIIPAERSLHqPMYIFLAVLAATDIGLCAAIAPKMLAIFWfqaYSMVfdaCLAQLFFI 107
gi 149578567  27 HWIGIPFCGMFTVAVLGNCTVLIVIKRNPELHqPMYLLLAMLALNDLGICPTIVPKTLGIFWfnlREIQfnsCLAQMFFV 106
gi 612023937  30 HWIGIPFCIMILLALMGNCTILSVIWRDPSLHqPMYLLLAMLAINDLGIFPVLFPKTLAILWfdiKEIEfnvCLTQMFFV 109
gi 557327631  28 VWIAIPFCVMYILAVTGNCTLLAIIKTERSLHePMYIFLAMLAGTDLVLSTCILPKMLGIFWfgsRDISfnaCLVQMFFI 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 74762730  107 HSFQaIESGILLAMALDRYVAICIPLrHATIFsQQFLTHIGLGVTLRAAILIIPSLGlik-ccLKHYRTtVISHSYCEHM 185
gi 585658434 107 HTFQcMESGILLAMAFDRYVAICEPLrHSAILtKKVLISIIMVVTIRASVIIIMCPLlik-lrLKHFRTtIISHSYCEHM 185
gi 47576405  108 HTLQcMESGILLAMAFDRYIAICDPLrHTSILtPSILGRMIVVVVVRAVVLVGLLPLli--krLHHFQSiHIAHSYCEHM 185
gi 149578567 107 HVLAaFETGILVAMALDRYVAICHPLrYSSILtPNVLLGMGLLVVLRGVFMILPFLLlikarvNSFRST-VVPHTYCEHM 185
gi 612023937 110 HVLAgFETGILVAMALDRYVAICRPLrYTAILtPHVLLGIAVMVVVRAVLLISFCPIlik-lrLTSFHStVVAHSYCEHM 188
gi 557327631 108 HTFQaVESGVLLAMAFDRYVAICNPLrHSSIFtTQVLFRIGILLVMRPTALIIPSICli--krLHFYKStAISHAYCEHM 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #  ### ### ##                                            #  ## ##  #
gi 74762730  186 AIVKLATEDirvNKIYGLFVAFAILGFDIIFITLSYVQIFITVfqlpqkEARFKAFNTCIAHICVFLQFYLLAFFSFFTH 265
gi 585658434 186 AVVKLAAENvkvNKAYGLFVAFSVLGFDVIFIFLSYAFIFRAVfklpqkEARFKAFNTCTAHIFVFLQFYILTFFTSFIH 265
gi 47576405  186 AVVKLAADDvriNKICGLFVGFSILGFDMVFILISYALIFQAVfrlqqkEARLKAFNTCTAHIFVFLEFYILAFFSFFSH 265
gi 149578567 186 AVLKLATDDtrvNRIYGLAVVFIIFWFDSSFITTSYTLIFKAVfrlpgkEARLKAFNTCTAHIIIIMLTYTLALFSFLGH 265
gi 612023937 189 AVVKLAAGDtrvNKFYGLAVVMTFCWCDICFISTSYILIFRAVmrlpgkEARVKAANTCTAHITIIVLSYSLALFSFLAH 268
gi 557327631 186 AVVKLAAVDvrvNKAYGLFVAFTILGVDIIFITVSYILILRAVfrlpqkEAHLKAFHTCTAHICVFLEFYTLGFFSFFAH 265
                        250       260       270
                 ....*....|....*....|....*....|....*..
Feature 1               ## ###  #  ##                 
gi 74762730  266 RFGshiPPYIHILLSNLYLLVPPFLNPIVYGVKTKQI 302
gi 585658434 266 RFGfnvAPYVHILLSNLYLLVPPLLNPIVYGVKTKQI 302
gi 47576405  266 RLGh-vVPSTHILLSTIYLLLPPALNPIVYGVKNMVI 301
gi 149578567 266 RYGhhlTPYVHILLANFYLLVPTVVNPIIYGAKTKEI 302
gi 612023937 269 RYGhrvAPYVHILLANIYLLVPPVVNPIVYGVKTKEI 305
gi 557327631 266 RFGhhvAPYIHILLSSLYLLVPPLLTPIVYGVNTKQI 302

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap