Conserved Protein Domain Family
7tmA_OR52W-like

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cd15956: 7tmA_OR52W-like 
olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320622
View PSSM: cd15956
Aligned: 3 rows
Threshold Bit Score: 376.127
Threshold Setting Gi: 205525921
Created: 17-Dec-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 205525921  30 TWLTLVFGPIYLLALLGNGALPAVVWIDSTLHqPMFLLLAILAATDLGLATSIAPGLLAVLWlgpRSVPyavCLVQMFFV 109
gi 47576811   27 VWISLPFCFMFVLSLTGNAVLLSLIWKEHRLHqPMFLFLAMLSFVDLVLSLSTLPKMLAIFWfgaTAISsyaCLSQMFLI 106
gi 602673181  27 RWLSIPFSSIYMVSLLGNGMILWVVSSETALHtPMFLFLSMLAATDLLLASSVALQLLRILWfdaGEIGfdvCLAQMFSV 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 205525921 110 HALTaMESGVLLAMACDRAAAIGRPLhYPVLVtKACVGYAALALALKAVAIVVPFPLLvakFEHFQAkTIGHTYCAHMAV 189
gi 47576811  107 HAFSaMESGVLVAMALDRFVAICNPLhYATILtLEVVAKIGGLVALRGVGLTIFFPSLacrLSFCAShTIAYTYCEHMSV 186
gi 602673181 107 HFFSaMESGTLMAMALDRYLAICWPLrYSSILtSSRVAKAGLLLVLRGVAIVGPCPLLvrrLSFCGSrVIAHSYCDHMAV 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                            #  ## ##  #  
gi 205525921 190 VELVVGNtqaTNLYGLALSLAISGMDILGITGSYGLIAHAVlqlptrEAHAKAFGTCSSHICVILAFYIPGLFSYLTHRF 269
gi 47576811  187 VKLACGAttvDSLYAFAVAIFLGVGDVAFIAYSYGQIVKTVmrfpspEARGKAGSTCTAHVCVILFFYGPGFLSVVMQRF 266
gi 602673181 187 VKLACASptvDSVYGLVLILLIGGSDMLSIGMSYALILRTIlrlpsqQAQLKAFSTCSAHICIILTFYIPGLVSLLMHRC 266
                        250       260       270
                 ....*....|....*....|....*....|....*.
Feature 1              ## ###  #  ##                 
gi 205525921 270 GhhtvPKPVHILLSNIYLLLPPALNPLIYGARTKQI 305
gi 47576811  267 Gps-tASAAKVILANLYLLFPPALDPIVYGIKTKQI 301
gi 602673181 267 Rhs-vPPSAHVLLSNLYMLLPPVLNPIVYGVRTKSI 301

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