Conserved Protein Domain Family
7tmA_GPR12

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cd15961: 7tmA_GPR12 
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors
GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.
Statistics
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PSSM-Id: 320627
View PSSM: cd15961
Aligned: 4 rows
Threshold Bit Score: 432.528
Threshold Setting Gi: 47223360
Created: 7-Oct-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the S1P1 receptor in complex with the selective antagonist ML56.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #               ##  ##  #
gi 1346168    45 NPWDIVLCTSGTLISCENAIVVLIIFHNPSlraPMFLLIGSLALADLLAGIGLITNFVFAyllqseatKLVTIGLIVASF 124
gi 465988113 177 NPWDIVLCTSGTLISCENAIVVLIIFQNPNlraPMFLLIGSLALADLLAGIGLIINFIFAyllqseatKLVTVGLIVSSF 256
gi 301624584  37 NPWDIVLCTSGTLISCENAIVVLIIFHNPSlraPMFLLIGSLALADLLAGVGLIVNFIFAyllqseaaKLVTVGLIAASF 116
gi 47223360   51 NPWDIVLCTSGTLIACENALVVLVIWQNPAlraPMFLLIGSLALADLLAGLGLVLHFTCAyllrseaaQLLTVGLVVASF 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                     #  
gi 1346168   125 SASVCSLLAITVDRYLSLYYAltYHSERtVTFTYVMLVMLWGTSICLGLLPvmgWNCLRDESTCSVvrPLTKNNAAILSV 204
gi 465988113 257 SASVCSLLAITVDRYLSLYYAltYNSERtVTFTYIMLILLWGASICIGLLPimgWNCLKDESTCSVirPLTKNNAAILSV 336
gi 301624584 117 CASVCSLLAITVDRYLSLYYAltYNSERtVTFTYVMLIFLWGASTCVGLLPimgWNCLEDESTCSVirPLTKNNAAALSV 196
gi 47223360  131 SASVFSLLAITIDRYLSLYYAltYNSERtAAFTYTMLVLLWGLSLCLGLLPvtgVNCLAEEATCSVvrPLTKNNVAVLSV 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                    #      #            
gi 1346168   205 SFLFMFALMLQLYIQICKIVMRHAHQIALQhhfla-tshyVTTRKGVSTLAIILGTFAACWMPFTLYSLIAdytyPSIYT 283
gi 465988113 337 SFLLMFALMLQLYIQICKIVMRHAHQIALQhhfla-tshyVTTRKGVSTLAIILGTFAACWIPFTLYSLIAdytyPSIYT 415
gi 301624584 197 SFLLMFALMLQLYIQICKIVMRHAHQIALQhhfla-tshyVTTRKGVSTLAIILGTFAACWMPFTLYSLIAdytyPSIYT 275
gi 47223360  211 SFLLLFGLMLQLYVQICKIVMRHAHQIALQhhflaatphyVTTRKGVSTLAIILGTFAACWMPFTVYSLIAdytyPPLYT 290
                        250       260
                 ....*....|....*....|....*....
Feature 1        #  #                         
gi 1346168   284 YATLLPATYNSIINPVIYAFRNqeIQKAL 312
gi 465988113 416 YATLLPATYNSIINPVIYAFRNqeIQKAF 444
gi 301624584 276 YATLLPATYNSIINPVIYAFRNqeIQKAL 304
gi 47223360  291 YATLVPATYNSVINPVIYAFRNqeIQKAL 319

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