Conserved Protein Domain Family
7tmA_GPR6

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cd15962: 7tmA_GPR6 
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.
Statistics
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PSSM-Id: 320628
View PSSM: cd15962
Aligned: 4 rows
Threshold Bit Score: 472.108
Threshold Setting Gi: 1170009
Created: 7-Oct-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the S1P1 receptor in complex with the selective antagonist ML56.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #               ##  ##  #
gi 1170009    73 NPWDVLLCVSGTVIAGENALVVALIASTPAlrtPMFVLVGSLATADLLAGCGLILHFVFQylvpsetvSLLTVGFLVASF 152
gi 47224588    2 NPWHIMLCLSGTVIACENAIVVAIIFYTPTlrtPMFVLIGSLATADLLAGMGLILNFVFQyvissetiSLITIGFLVTSF 81
gi 512842075  38 NPWDIMLCISGTIIACENAIVVAIIFYTPTlrtPMFVLIGSLATADLLAGFGLILNFVFQyviqsetiSLITVGFLVASF 117
gi 565305207  38 NPWDIMLCISGTIIACENAIVVAIIFYTPNlrtPMFVLIGSLATADLLAGVGLILNFVFQyviqsetiSLITVGFLVASF 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                     #  
gi 1170009   153 AASVSSLLAITVDRYLSLYNAltYYSRRtLLGVHLLLAATWTVSLGLGLLPvlgWNCLAERAACSVvrPLARSHVALLSA 232
gi 47224588   82 TASISSLLAITVDRYFSLYNAltYFSEKtVQYVHLMLLGTWGVSLFLGLLPvlgWNCLEEPASCSIvrPLTQSNITLLAT 161
gi 512842075 118 TASVSSLLAITVDRYLSLYNAltYSSEKtILWIHMMLVVTWGVSLCLGLLPvlgWNCLDDDSSCSIvkPLTKSNVTLLST 197
gi 565305207 118 TASVSSLLAITVDRYLSLYNAltYYSEKtVFCIHMMLIITWGVSLCLGLLPvlgWNCMEDYSSCSIvrPLTKSNVTLLSA 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                   #      #            #
gi 1170009   233 AFFMVFGIMLHLYVRICQVVWRHAHQIALQqhclapphlAATRKGVGTLAVVLGTFGASWLPFAIYCVVGshedPAVYTY 312
gi 47224588  162 SFFAIFILMLTLYFKICKIVCHHAHQIALQqhffttshyVATKKGISTLAIILGTFGASWLPFAIYCLVGkreyPQVYTY 241
gi 512842075 198 SFFFIFILMLHLYIKICKIVCRHAHQIALQqhfltashyVATKKGVSTLAIILGTFGASWLPFAIYCVVGdhdyPSVYTY 277
gi 565305207 198 SFFFIFILMLHLYIKICKIVCRHAHQIALQqhfltashyVATKKGVSTLAIILGTFGASWLPFAIYCVIGdsnyPAVYTY 277
                        250       260
                 ....*....|....*....|....*...
Feature 1          #                         
gi 1170009   313 ATLLPATYNSMINPIIYAFRNqeIQRAL 340
gi 47224588  242 ATLLPATYNSMINPIIYAYRNteIQRSI 269
gi 512842075 278 ATLLPATYNSMINPIIYAYRNqeIQRSM 305
gi 565305207 278 ATLLPATYNSMINPIIYAYRNqeIQRSM 305

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