Conserved Protein Domain Family
7tmA_GPR3

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cd15963: 7tmA_GPR3 
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors
GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.
Statistics
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PSSM-Id: 320629
View PSSM: cd15963
Aligned: 4 rows
Threshold Bit Score: 423.525
Threshold Setting Gi: 1170006
Created: 7-Oct-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the S1P1 receptor in complex with the selective antagonist ML56.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #               ##  ##  #
gi 1170006    41 KAWDVVLCISGTLVSCENALVVAIIVGTPAfraPMFLLVGSLAVADLLAGLGLVLHFAAVfcigsaemSLVLVGVLAMAF 120
gi 573887427  39 NPWDVVLCISGTVIACENAIVVAVIFYTPSlrtPMFLLIGSLATADLLAGLGLILHFVFLycvqseavNLITVGLLVASF 118
gi 465966583  35 NPWDVMLCISGTIISCENAIVVAVIFYTPAfrtPMFLLIGSLAIADFLAGMGLIFHFAFVyciqsqvvNLITVGLLVTSF 114
gi 677167349   2 NPWDVVLCVSGTVISCENAVVVVVIFYAPAfraPAFLLIGSLATADLLAGLGLILRFAFVyfs---psEAVSLLTAAPPF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                     #  
gi 1170006   121 TASIGSLLAITVDRYLSLYNAltYYSETtVTRTYVMLALVWGGALGLGLLPvlaWNCLDGLTTCGVvyPLSKNHLVVLAI 200
gi 573887427 119 TASVSSLLAITIDRYLSLYNAltYYSEHtVTRTYIMLILTWGVSLCLGMLPvvgWNCLKDTASCSIvrPLTKTNLVILSV 198
gi 465966583 115 TASVGSLLAITIDRYLSLYNAltYYSERtVTRTYIMLILTWGFSICFGLLPvmgWNCLKDISTCSIvkPLTKNNLIILSI 194
gi 677167349  79 TASVSSLLTITIDRYLSLYNAltYYSARtVTRTYIMLILTWGASLCLGLLPvvgWNCLKEPSTCSVvkPLTKNHLSSFFA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                   #      #            #
gi 1170006   201 AFFMVFGIMLQLYAQICRIVCRHAQQIALQrhllpashyVATRKGIATLAVVLGAFAACWLPFTVYCLLGdahsPPLYTY 280
gi 573887427 199 SFFMVFALMLQLYAQICKIVCRHAHQIALQrhflptshyVTTRKGISTLAVILGTFASCWLPFAIYCLLGdytyPPIYTY 278
gi 465966583 195 SFFMVFAVMLQLYVQICKIVCRHAHQIAVQrhflatshyVTTRKGISTLAVILGTFASCWLPFAIYCLLGdytyPALYTY 274
gi 677167349 159 VLAAMLQLSVQICKIIRRHAHQIAIQRHFLags----hyVTTRKGVATLAVILGTFASCWLPFAVYGLLGdysyPALYTY 234
                        250       260
                 ....*....|....*....|....*...
Feature 1          #                         
gi 1170006   281 LTLLPATYNSMINPIIYAFRNqdVQKVL 308
gi 573887427 279 ITLLPATYNSMINPIIYAFRNqeIQKVL 306
gi 465966583 275 MTILPATYNSMINPVIYAFRNqeIQKVL 302
gi 677167349 235 ATLLPATYNSMINPIIYAFRNpeIQKVL 262

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