Conserved Protein Domain Family
7tmA_SSTR1

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cd15970: 7tmA_SSTR1 
somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors
G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.
Statistics
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PSSM-Id: 320636
View PSSM: cd15970
Aligned: 6 rows
Threshold Bit Score: 499.053
Threshold Setting Gi: 512862219
Created: 6-Oct-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##           ###### ##
gi 401124     59 ILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTaTNIYILNLAIADELLMLSVPFLVTSTLLRhWPFGallCRLVLSVDA 138
gi 6446422    35 IFISFIYSVVCLVGLCGNSMVIYVIFRYAKMKTaTNIYILNLAIADDLLMLSVPFLVTSSLLHhWPFGsllCRLVLSVDA 114
gi 556955534  36 ILISFIYSVVCLIGLCGNSMVIYVILRYAKMKTaTNIYILNLAIADELLMLSVPFLVTSTLLRhWPFGsllCRLVLSVDA 115
gi 163915347  60 ILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTaTNIYILNLAIADELLMLSVPFLVTSTLLHhWPFGsllCRLVLSVDA 139
gi 632951910  35 ILISFIYSVVCFVGLCGNSLVIYVILRYAKMKTaTNIYILNLAIADELLMLSVPFLVTYTLLGqWPFGsmlCRLVLSVDA 114
gi 512862219  39 IFISFVYSLVCIVGLCGNSVVIYVILRYAKMKTaTNIYILNLAIADELLMLSVPFLVTSTLLRhWPFGsllCRLVLSLDA 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                            # #####                          
gi 401124    139 VNMFTSIYCLTVLSVDRYVAVVHPikAARYRrPTVAKVVNLGVWVLSLLVILPIVVFSrtaansDGTVACNMLMPepaqr 218
gi 6446422   115 INMFTSIYCLTVLSIDRYISVVHPikAARYRrPTIAKMVNLGVWMFSILVILPIIIFSttapnsDGSVACNMQMPeperq 194
gi 556955534 116 INMFTSIYCLTVLSIDRYIAVVHPikAASYRrPTVAKMVNLGVWVFSMVVILPIIIFSntatnsDGSVACNMQMPepsqq 195
gi 163915347 140 INMFTSIYCLTVLSVDRYIAVVHPikAARYRrPTVAKMVNLGVWVLSILIILPIIIFSntaansDGTVACNMLMPeptqr 219
gi 632951910 115 INMFTSVYCLTVLSADRYIAVVHPikAASYRrPTIAKMVNLAVWLLAILVILPIIIFSntatasDGSVTCNMQMPepstr 194
gi 512862219 119 MNMFTSVYCLAVLSLDRYVAVVHPisAARYRrPSVAKMVNLGVWLFSILIILPIVVFSstapnsDGTVACNVLMPepsqr 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  ### ### ##                                                   #  ## ##  #    
gi 401124    219 WLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRmvalkagwqqRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNvfae 298
gi 6446422   195 WMAVFVIYAFLMGFLFPVIAICMCYILIIVKMRvvalkagwqqRKKSERKITLMVMMVVTVFVICWMPFHIVQLVSvfvq 274
gi 556955534 196 WLAVFVVYTFLMGFLFPVIAICMCYILIIVKMRvvalkagwqqRKKSERKITLMVMMVVTVFVICWMPFYIVQLVSvfvg 275
gi 163915347 220 WLVVFVVYTFLMGFLLPVVAICLCYILIIAKMRmvalkagwqqRKRSERKITLMVMMVVMVFVICWMPFYIVQLVNvfve 299
gi 632951910 195 WPAVFVVYTFLMGFLIPVTAICLCYILIIMKMRvvalkagwqqRKRSERKITLMVMMVVTVFVICWMPFYVVQLVDvfvg 274
gi 512862219 199 WVVVFVLYTFLMGFLLPMAAICLCYILIITKMRvvalkagwqqRRRSERKLTLMVTVVVTVFVVCWMPFYVVQLVGvfar 278
                        250       260       270
                 ....*....|....*....|....*....|....*.
Feature 1          ## ###  #  ##                     
gi 401124    299 qdDATVSQLSVILGYANSCANPILYGFLSdNFKRSF 334
gi 6446422   275 qhNSTLSQLAVILGYANSCANPILYGFLSdNFRRSF 310
gi 556955534 276 qhDATVSQLSVILGYANSCANPILYGFLSdNFKRSF 311
gi 163915347 300 qdDATISQLSVILGYANSCANPILYGFLSdNFKRSF 335
gi 632951910 275 qqDTTISQLSVILGYANSCANPVLYGFLSdNFKRSF 310
gi 512862219 279 kgDTTVSQLSVALGYANSCANPFLYGFLSdNFKRSF 314

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