Conserved Protein Domain Family
7tmA_SSTR3

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cd15972: 7tmA_SSTR3 
somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors
G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.
Statistics
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PSSM-Id: 320638
View PSSM: cd15972
Aligned: 5 rows
Threshold Bit Score: 430.378
Threshold Setting Gi: 417815
Created: 6-Oct-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 417815     45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPS-VTNVYILNLALADELFMLGLPFLAAQNALSyWPFGslmCRLVMAVD 123
gi 47204544   49 ILIPLTYIVVCIVGLGGNTLVIHIVLRYSKIES-VTNIYILNLAIADELFMFGLPFMAVQNAFHlWPFGsfmCRLVMTVD 127
gi 66793455   45 VLIPMVYLIVCVVGLIGNSLVIYVVLRHSVSES-VTNVYILNLALADELFMLGLPFLAAQNALSyWPFGsfmCRLVMAVD 123
gi 557023946  50 VIIPLIYFVVCVVGLGGNTLVIHVVLWYAKMES-VTNIYILNLAVADELFMLGLPFLAVQNALSyWPFGslmCRLVMTVD 128
gi 512837062  36 LLIPLVYLVVCAVGLWGNTLVIYLAWRSPAGQNsVTALYILNLALADDLFMLGLPFLAAQNALSyWPFGspaCRLVMTLD 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                        #
gi 417815    124 GINQFTSIFCLTVMSVDRYLAVVHPtRSARWRtAPVARTVSAAVWVASAVVVLPVVVFSGVPrgMSTCHMQWPEPaaaWR 203
gi 47204544  128 SINQFTSIFCLTVMSVDRYLAVVHPiRSSKWRhPQVAKTVNCTVWALSFLVVLPVVIFANIPkaGGTCNIAWPQPanvWQ 207
gi 66793455  124 AINQFTSIFCLTVMSVDRYLAVVHPgKSSKWRtARVAKAVSATVWMLSSIVVLPVVVFSDVPlgMNTCHIQWPEPasvWR 203
gi 557023946 129 GINQFTSIFCLTVMSIDRYLAVVHPvKSSKWRkPPVAKTVNATVWAVSFVVVLPVVIFADVPagMSTCNINWPEPatvWQ 208
gi 512837062 116 AVNQFTSIFCLTVLSFDRYLAVVRPiQSAKWRkPKVAKCVNVTVWILSFLVVLPVVFFSGVPgdTGTCHIAWPEPaqmWR 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          ### ### ##                                                      #  ## ##  #   
gi 417815    204 AGFIIYTAALGFFGPLLVICLCYLLIVVKVRsagrrvwapscqrRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNvvc 283
gi 47204544  208 TAFIVYTSTVGFFCPLLIICLCYVFILFKIRssakkv-hatstkRRKSERKVTHMVVIIVAMFVFCWLPFYALNIVNllv 286
gi 66793455  204 AGFIIYTATLGFFGPLLVICLCYLLIVVKVRssgrrv-ralsskHKLSERRVTRMVVTVVAVFVLCWLPFYVLNIINvvc 282
gi 557023946 209 AAFIIYTATLGFFAPLTVICLCYLLIIIKVKssgrkv-ratstkRKQSERKVTRMVVIVVVAFVFCWLPFYMLNIVNlva 287
gi 512837062 196 TGFILYTAALGFFCPLLVICICHLLIVAQVRssgkrv-rvapnrRQGPERKVTKMVALTVTAFVLCWFPFYALNIINllw 274
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
Feature 1               ## ###  #  ##                     
gi 417815    284 plpeePAFFGLYFLVVALPYANSCANPILYGFLSyRFKQGF 324
gi 47204544  287 --slpPEHQGLYSFVVVLGYANSCANPIVYCFLSdNFKKGF 325
gi 66793455  283 plpeePSLFGVYFLVVVLPYANSCANPIIYGFLSyRFKQGF 323
gi 557023946 288 tlpkdPSLFGIYFFVVVLSYANSCANPIIYSFLSdNFKQGF 328
gi 512837062 275 plpesPKLYGLYSFVVALSYANSCLNPIIYALLArPFQRGL 315

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