Conserved Protein Domain Family
7tmA_SSTR4

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cd15973: 7tmA_SSTR4 
somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors
G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.
Statistics
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PSSM-Id: 320639
View PSSM: cd15973
Aligned: 5 rows
Threshold Bit Score: 481.663
Threshold Setting Gi: 206729897
Created: 6-Oct-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##           ###### ##
gi 206729897  48 VAIQCIYALVCLVGLVGNALVIFVILRYAKMKTaTNIYLLNLAVADELFMLSVPFVASSAALRhWPFGsvlCRAVLSVDG 127
gi 71895761   42 VVIQCIYALVCLLGLLGNSLVIFVILRYTKMKTaTNIYLLNLAIADELFMLSIPFVATSAALHhWPFGralCRTVLGVDG 121
gi 512843562  58 IVIQFIYAIVCLIGLIGNSMVIFVILRYAKMKTaTNIYILNLAIADELFMLSVPFLAASAALQhWPFGsgmCRTVLSVDG 137
gi 556961882   2 VVIQFIYAVVCLIGLIGNSMVIFVILRYAKMKTaTNIYILNLAIADELFMLSVPFLSASAALQhWPFGswmCRTVLSVDG 81
gi 632953930   6 VVIQFIYAIVCLVGLIGNSMVIFVILRYAKMKTaTNIYILNLAIADELFMLSVPFLSASTALQrWPFGslmCRTVLSVDG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                            # #####                          
gi 206729897 128 LNMFTSVFCLTVLSVDRYVAVVHPlRAATYRrPSVAKLINLGVWLASLLVTLPIAIFAdtrpargGQAVACNLQWPhpaW 207
gi 71895761  122 LNMFTSVFCLTVLSLDRYIAVVHPlRAATYRrPRVAKMVNGAVWLLSLLVASPIPIFAgtavtrdGQAVACNLLWPspaW 201
gi 512843562 138 INMFTSVFCLTVLSVDRYVAVVHPlRAARYRrPTVAKMINICVWIVSLLVISPILIFAdtm-pskNGVVVCNLMWPhqtW 216
gi 556961882  82 INMFTSVFCLTVLSVDRYIAVVHPiKAARYRrPTVAKMINLCVWIVSLIVISPIIIFAdtk-tteDEIVVCNLIWPgpsW 160
gi 632953930  86 INQFTSVFCLTVLSVDRYIAVVHPiKAARYRrPTIAKIINICVWILSLVVILPIIIFAgta-pnkDGGVACNFIWPepsW 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ### ### ##                                                   #  ## ##  #     
gi 206729897 208 SAVFVVYTFLLGFLLPVLAIGLCYLLIVGKMRavalragwqqRRRSEKKITRLVLMVVVVFVLCWMPFYVVQLLNlfv-t 286
gi 71895761  202 SAAFVVYTTLLGFLLPVLAMGLCYLLIVGKMRavaqrvgwqqRRRSEGKLTRLVLMVVAMFVVCWMPFYVVQLVNlllpg 281
gi 512843562 217 SAVFVIYTFLLGFFLPVVAICLCYILIIIKMRavalkagwqqRKKSEKKITRMVLMVVTVFVICWMPFYIVQLLNlfl-p 295
gi 556961882 161 STAFVIYTFLLGFFVPVFAISLCYILIIVKMRavalkagwqqRKKSEKKITRMVMLVVTVFVICWMPFYVVQLLNlfl-p 239
gi 632953930 165 SVAFVIYTFLLGFLIPIFAICLCYILMIVKMRvvglkagwqqRRKSEKKITRMVLMVVTVFVICWMPFYVVQLLNifl-w 243
                        250       260       270
                 ....*....|....*....|....*....|....*.
Feature 1          ## ###  #  ##                     
gi 206729897 287 slDATVNHVSLILSYANSCANPILYGFLSdNFRRFF 322
gi 71895761  282 rlDATVNNACLILSYSNSCANPILYGFLSeNFRHSF 317
gi 512843562 296 hmDATINHISLILSYANSCANPILYGFFSdNFKRSF 331
gi 556961882 240 qmDATINHFSLILSYANSCANPILYGFLSdNFRRSF 275
gi 632953930 244 rlDTTVTHLSVILSYANSCANPILYGFLSdNFKRSF 279

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