Conserved Protein Domain Family
7tmA_SSTR5

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cd15974: 7tmA_SSTR5 
somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors
G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.
Statistics
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PSSM-Id: 320640
View PSSM: cd15974
Aligned: 6 rows
Threshold Bit Score: 466.2
Threshold Setting Gi: 12644225
Created: 6-Oct-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##           ###### ##
gi 61743877   34 VLIPIFYILVCAVGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADVLFMLGLPFLATQNAISyWPFGsflCRLVMTVDG 113
gi 12644225   41 VLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASfWPFGpvlCRLVMTLDG 120
gi 46249963   35 KALAVIYLVVFIVGLTGNSLAIFVVLRYTKMKTVTNMYILNLAVADELYILGLPFLTTHNVLSyWPFGnflCRILMWADS 114
gi 557022257 103 VLIPVVYFLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYIVNLAVADELFMLGLPFLATQNAISyWPFGsflCRLVMTVDG 182
gi 512868661  44 FIIPLIYLLVCVIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADVLFMLGLPFLATQNAISyWPFGtflCRLVMTVDG 123
gi 632970586  44 LLISVIYLIVCAIGLSGNSLVIYVVLRYAKMKTVTNVYILNLAVADELFMLGLPFLATQVALSyWPFGsfmCRLVLTVDG 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                            # #####                        # 
gi 61743877  114 INQFTSIFCLTVMSMDRYLAVVHPIKSTKWRRPRVAKLISMTVWTFSFLVVLPVFIFSDvqedFHTCNMNWPEPvnIWSA 193
gi 12644225  121 VNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADvq-eGGTCNASWPEPvgLWGA 199
gi 46249963  115 ISQFTSTFCLTVMSIDRYMAVVHPIRSARWRRPSVAKVINSMVWALSCLLTLPVIIYCDvqpgLNTCNLSWPEPrdVWST 194
gi 557022257 183 INQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKVINATVWTLSFLVVLPMIIFADvqedIQTCNINWPEPmaVWST 262
gi 512868661 124 VNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLISATVWTLSFLVTLPVIIFSEvqpdYHTCNISWPDPvsVWAA 203
gi 632970586 124 VTQFTSIFCLTVMSIDRYLAVVHPIKSTKWRKPRVAKMINATVWTSSIVVVLPVIIYSElqkdLNTCNIDWPEPksVWST 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ### ### ##                                                   #  ## ##  #       
gi 61743877  194 AFIIYTSVLGFFGPLLVICLCYLLIVIKVKssgirvgstrRRRSERKVTRMVVIIVVVFVFCWLPFYMMNIVNLIFILPe 273
gi 12644225  200 VFIIYTAVLGFFAPLLVICLCYLLIVVKVRaagvr-vgcvRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPq 278
gi 46249963  195 AFILYTAILGFFCPLLVICLCYLLIVIKVKsasaraglskRRKSEKKVTRMVVIIVVVFVICWLPFFMLNIFNLVVTLPe 274
gi 557022257 263 AFIIYTSVLGFFAPLLVICLCYLLIVIKVKssglrvgstkRRKSERKVTRMVVIIVVVFVFCWLPFYILNIVNLIVILPe 342
gi 512868661 204 AFIIYTSVLGFFGPLSVICLCYLLIVIKVKssglrvgstrRRRSERKVTRMVVIIVAVFVFCWLPFYILNIVNLSFFVPe 283
gi 632970586 204 AFIIYTATLGFFGPLLIICLCYLMIVIKVKssrlrvgstkRRKSEKKATRMVIVIVAVFVFCWLPFYVLNIVNTIVILPe 283
                        250       260       270
                 ....*....|....*....|....*....|....*..
Feature 1           ## ###  #  ##                     
gi 61743877  274 dpvLVGVYFFVVVLSYANSCANPILYGFLSDNFKQSF 310
gi 12644225  279 epaSAGLYFFVVILSYANSCANPVLYGFLSDNFRQSF 315
gi 46249963  275 nniITGVYFLTVILTYVNSCANPLLYGFLSDNFKRSF 311
gi 557022257 343 epaLVGVYFSVVVLSYANSCANPILYVFLSDNFKQSF 379
gi 512868661 284 epaFAGVYFFVVVLSYANSCANPILYGFLSDNFKQSF 320
gi 632970586 284 kpiFVGIYFFGVVLPYANSCANPVLYCFLSDNFKKSF 320

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