Conserved Protein Domain Family
7tmA_ET-CR

?
cd15977: 7tmA_ET-CR 
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.
Statistics
?
PSSM-Id: 320643
View PSSM: cd15977
Aligned: 3 rows
Threshold Bit Score: 504.054
Threshold Setting Gi: 416973
Created: 10-Oct-2014
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 45383870   91 YINTIVSCTIFIVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIALPINVYKLlakdWPFGvqvCKLVPFIQ 170
gi 416973     89 YVTTILSCVIFLVGIVGNSTLLRIIYKNKCMRNGPNVLIASLALGDLFYILIAIPIISISF----WLSTghsEYIYQLVH 164
gi 410913375  75 YVNTIISCLIFVVGIIGNSTLLRIIYKNKCMRNGPNVLIGSLALGDLLYIIIAIPINVFKLiaedWPFGvyvCKLMPFIQ 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 45383870  171 KASVGITVLSLCALSIDRYRAVASWsrIQGIGiPMWKAVEVTVIWAVAIVLAVPEAIAFDMVEINYwdqdlwVCMLASEQ 250
gi 416973    165 LYRARVYSLSLCALSIDRYRAVASWnrIRSIGiPVRKAIELTLIWAVAIIVAVPEAIAFNLVELDFrgqtilVCMLPMEQ 244
gi 410913375 155 KASVGITVLSLCALSIDRYHAVTSWsrVKGMGiPLWKAVEVTLIWLVAVLFAVPEALAFDMLEIPYrskklrVCLLHPEQ 234
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                #  ### ### ##                                                     #  ## 
gi 45383870  251 kssFMMFYRDVKDWWLFGFYFCLPLVCTGIFYTLMSCEMLskrngmrialndHMKRRREVAKTVFCLVVIFALCWLPLHL 330
gi 416973    245 tsdFMRFYQEVKVWWLFGFYFCLPLACTGVFYTLMSCEMLsikngmrialndHMKQRREVAKTVFCLVVIFALCWLPLHV 324
gi 410913375 235 ttsFMKFYQDVKDWWLFGFYFCLPLACTAFFYTLMSCEMLsrkkgmrialndHMKQRREVAKTVFCLVLIFALCWLPLHL 314
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  #                               ## ###  #  ##                     
gi 45383870  331 SRILKktiydqtdp--------------nrcellsfLLVMDYFGINMASLNSCINPVALYFVSRKFKNCF 386
gi 416973    325 SSIFVrlsatvkracilknkrscimaeiqtgvnyqlLMVMNYTGINMASLNSCIGPVALYFVSRKFKNCF 394
gi 410913375 315 SRILKktiydendp--------------hrcellsfLLVMDYIGINMASLNSCINPIALYFVSQKFKNCF 370

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap