Conserved Protein Domain Family
7tmA_CCK-BR

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cd15979: 7tmA_CCK-BR 
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors
Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.
Statistics
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PSSM-Id: 320645
View PSSM: cd15979
Aligned: 5 rows
Threshold Bit Score: 445.413
Threshold Setting Gi: 417029
Created: 11-Dec-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 2495001    69 WVRIVMYSVIFLLSVFGNTLIIIVLVMNKRlRTITNSFLLSLALSDLMVAVLCMPFTLIPNLmenFIFGeviCRAAAYFM 148
gi 48976043   57 TVRVLLYALIFVLSVCGNALVVAVLLLNRRlRTVTNSFLLSLALSDLMLALCCMPFTLIPNLmgtFVFGeavCKLMAYLM 136
gi 417029     55 AIRITLYAVIFLMSVGGNMLIIVVLGLSRRlRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLmgtFIFGtviCKAVSYLM 134
gi 632987984   4 TVRILLYSIIFLLSFFGNMMIIVVLILNKRlRTVTNSFLLSLALSDLMVAIFCMPFTLIPNLlgdFIFGetmCKVTAYFM 83
gi 459442068  58 SLRILLYSVIFLLSVLGSLLIIVVLAVNKRmRTVTNSFLLSLAVSDLMMAIFCMPFTLIPNLledFIFGpamCKIVAYLM 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 2495001   149 GLSVSVSTFNLVAISIERYSAICNPlkSRVWQtrSHAYRVIAATWVLSSIIMIPYLVYnktvtfpm-kdrrvghQCRLVW 227
gi 48976043  137 GVSVSVSTFSLVAIAIERYSAICNPlqSRVWQtrSHACRVIASTWLFSALLMLPYAVYsttrllpvpgarpplsQCTHAW 216
gi 417029    135 GVSVSVSTLSLVAIALERYSAICRPlqARVWQtrSHAARVIVATWLLSGLLMVPYPVYtvvqpv-----gprvlQCVHRW 209
gi 632987984  84 GISVSVSTFSLVAIAIERYSAICNPlqSRAWQtrSHAYRVIAATWIISIIIMIPYPVYfllvqfkk-pdksfghMCRLAL 162
gi 459442068 138 GVSVSISTFSLVAIAIERYSAICNPlkSRAWQtrSHAYRVIAATWLLSFMIMTPYPVFshlkhvplkdnmtitrMCRHIW 217
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #  ### ### ##                                                              
gi 2495001   228 PskqVQQAWYVLLLTILFFIPGVVMIVAYGLISRELYRGiqfemdlnkeakahkngvstpttipsgdegdgcy------- 300
gi 48976043  217 PsehVRQAWYVLLLLVLFFIPGVVMIVAYGLISRELYRGirfeldikgeaaaqrsteplptcdegdgcylq--------- 287
gi 417029    210 PsarVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGlrfdgdsdsdsqsrvrnqgglpgavhqngrcrpetgavged 289
gi 632987984 163 PsiqVQQAWYVFLLIILFFLPGLVMIVAYGLISCELYRGiqfevtqkkdakghrngagtglggagphgsedndgc----- 237
gi 459442068 218 PypeVEQTWNMMLLLTLFVVPGVVMIVAYGLISRELYRGiqfemvqktsspglkngltttgacgsddgdgcyvq------ 291
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ## ##  #           ##
gi 2495001   301 -iqvtkrrntmemstltpsvctkmdrarinnseakLMAKKRVIRMLIVIVAMFFICWMPIFVANTWKAFdelsafntlTG 379
gi 48976043  288 ----lsrpggalelralgaagaqqerarinsseakLVAKRRVIRMLVVIVAMFFLCWLPIFAANTWRAFapraaqralSG 363
gi 417029    290 sdgcyvqlprsrpaleltaltapgpgsgsrptqakLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFdgpgahralSG 369
gi 632987984 238 yiqagksgnavemsmltpagsakldrarsnaseskLVAKKRVIRMLIVIVVMFFICWMPIFSVNTWRAFdqlsaarrlSG 317
gi 459442068 292 -lakrprsmemstltsstattsklerprsntseakLLAKKRVIRMLVVIVALFFLCWFPLYCANTWKAFhpvsarralSG 370
                        330       340       350
                 ....*....|....*....|....*....|..
Feature 1         ###  #  ##                     
gi 2495001   380 APISFIHLLSYTSACVNPLIYCFMNkRFRKAF 411
gi 48976043  364 TPISFIHLLSYTSACANPLIYCFMNrRFRSAF 395
gi 417029    370 APISFIHLLSYASACVNPLVYCFMHrRFRQAC 401
gi 632987984 318 APISFIHLLSYTSACVNPIVYCFMNkRFRKAL 349
gi 459442068 371 APISFIHLLSYTSACVNPITYCFMNtRFRTAL 402

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