Conserved Protein Domain Family
7tmA_NPFFR1

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cd15981: 7tmA_NPFFR1 
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.
Statistics
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PSSM-Id: 320647
View PSSM: cd15981
Aligned: 5 rows
Threshold Bit Score: 512.448
Threshold Setting Gi: 13878599
Created: 11-Dec-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 13878599   44 AMFIVAYALIFLLCMVGNTLVCFIVLKNRHmhtvTNMFILNLAVSDLLVGIFCMPTTLVDNlitgWPFDnatCKMSGLVQ 123
gi 45383432   45 VMFILAYTFIFLMCMIGNILVCFIVVKNRQmrtvTNMFILNLAISDLLVGIFCMPTTLVDNlitgWPFDnamCKMSGLVQ 124
gi 556962777  30 AMFIVAYVFIFLICMIGNFLVCFIVLKNKQmrtvTNMFILNLAVSDLLVGIFCMPTTLVDNlitgWPFNnvmCKMSGLVQ 109
gi 284447266  53 AALTLAYLFIFLLCMVGNGLVCLIVLENRRmrtvTNLFILNLAVSDLLVGVFCIPTTLVDNlitgWPFTntvCKMSGLVQ 132
gi 512851301   1 MFILAYTFIFLMCMIGNMLVCFIVLKNRQMrt-vTNMFILNLAISDLLVGIFCMPTTLVDNlitgWPFDnimCKMSGLVQ 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                          # #####                           
gi 13878599  124 GMSVSASVFTLVAIAVERFRCIVHPfrEKLTLrKALVTIAVIWALALLIMCPSAVTLTVtreehh--fmvdarNRSYPLY 201
gi 45383432  125 GMSVSASVFTLVAIAVERFRCIVHPfrQKLTLrKALVTIAIIWVLALLIMCPSAITLTVtreehh--fmvdtyNNSYPLY 202
gi 556962777 110 GMSVSASVFTLVAIAVERFRCIVHPfrQKLTLrKAIITIVLIWVLALIIMCPSAVTLTVtleeyh--fmvdeyNNSYPLY 187
gi 284447266 133 GMSVSASVFTLVAIAVDRFRCIVYPfqPKLTLlVAKVTIVMIWVLAVVIMCPSAVTLTVervehhymvrgedyNHTYPLF 212
gi 512851301  80 GMSVSASVFTLVAIAVERFRCIVYPfrQKLTLrKAIITIIIIWVLALIIMCPSAVTLTVtkddfh--fmvddyNNYYPLY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #  ### ### ##                                                        
gi 13878599  202 SCWEAWPekgMRRVYTTVLFSHIYLAPLALIVVMYARIARKLcqapgpapgg----------------eeaadprasRRR 265
gi 45383432  203 SCWEAWPeteMRRIYTTVLFSHIYVAPLALIVVMYARIAFKLfksaapargtr--------------peepegrkvsRRK 268
gi 556962777 188 SCWEAWPdqeMRKIYTTVLFSHIYLAPLTLIVIMYARIAFKLfkssapirdsh--------------ldeqegrrvsKKK 253
gi 284447266 213 SCFENWAnpqMRKVYTTVLFAHIYLIPLTLITLMYGRIGIKLyttsvisgndqhdggqphtspqapggqqegrplisQKK 292
gi 512851301 158 SCWEEWPdteMRKIYTTVLFSHIYLAPLTLIVIMYARIAFKLfkssapirgsv--------------seenegrrvsKRK 223
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
Feature 1                         #  ## ##  #             ## ###  #  ##                     
gi 13878599  266 ARVVHMLVMVALFFTLSWLPLWALLLLIdygqlsapqlhlvTVYAFPFAHWLAFFNSSANPIIYGYFNenFRRGF 340
gi 45383432  269 AKVINMLIIMALFFTLSWLPLWTLMLLTdyrhlsehqlhlvTGYVFPFAHWLAFFNSSANPIIYGYFNenFRRGF 343
gi 556962777 254 IKVINMLIIVALFFTLSWLPLWTLMLLTdygnltedqlnlmTVYIFPFAHWLAFFNSSVNPIIYGYFNenFRRGF 328
gi 284447266 293 IKVIKMLSIVALLFTISWLPLWTLMLLTdygglnedelellSGYVFPFAHWLAFSNSSVNPIIYGYYNenFKRGF 367
gi 512851301 224 VRVIYMLIIVALFFSLSWLPLWTLMLLTdyghlsdyqlnliAVYVFPFAHWLAFFNSSVNPIIYGYFNenFRRGF 298

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