Conserved Protein Domain Family
7tmB2_GPR56

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cd15995: 7tmB2_GPR56 
orphan adhesion receptor GPR56, member of the class B2 family of seven-transmembrane G protein-coupled receptors
GPR56 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR64, GPR97, GPR112, GPR114, and GPR126. GPR56 is involved in the regulation of oligodendrocyte development and myelination in the central nervous system via coupling to G(12/13) proteins, which leads to the activation of RhoA GTPase. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.
Statistics
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PSSM-Id: 320661
View PSSM: cd15995
Aligned: 3 rows
Threshold Bit Score: 460.836
Threshold Setting Gi: 68565559
Created: 1-Jul-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative polypeptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on mutagenesis of human glucagon receptor (GCGR), and modeling studies of GCGR and other related class B GPCRs
  • Comment:Residues in the globular N-terminal extracellular domain and the extracellular loops of the 7TM domain may also be involved in ligand binding.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #   #                                            #  ##  #        #      #
gi 68565559  400 KHYLSLLSYVGCVVSALACVVTIAAYLCSRRkpr--dytIKVHMNLLLAVFLLDTSFLLSEPVAltgseAGCRASAIFLH 477
gi 465970858 486 KKYLTIITYIGCIISAVASLFTIIFCCCSRRkhrdgtknIYIHMNLLGAIFLLDVSFLITEHLAsigsgAACRAGGMFLH 565
gi 602650049 407 YEYLTIVTYVGCIISALASFFTIFFFLCSKKkqr--dhiVYVHMNLLWAIFLLDMSFLIAVPLAptggdMACKAGGMFLH 484
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 68565559  478 FSLLACLSWMGLEGYNLYRLVVEVFGTYvpGYLLKLSAMGWGFPIFLVTLVALVDVDNYGpiilavhrtpegvIYPSMCW 557
gi 465970858 566 LSLLCCLTWMGIEGYNLYRLVVEVFNTYveHFILKLCAVGWGLPIFIVGVIFLADQTNYGpfhievfesleksTNATICW 645
gi 602650049 485 FGVLACLTWMAIEGYSLYRLVIEVFNSYvkHFLFKLCLVGWGLPIFMVCLIFAIDQSYYGpssfkvykspdkyTKATICW 564
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              ## # #                                               #  #             #   
gi 68565559  558 IRdSLVSYITNLGLFSLVFLFNMAMLATMVVQILRLRPhtQKWSHVLTLLGLSLVLGLPWALIFFSFASGtFQLVILYLF 637
gi 465970858 646 ITaPLIHNIVNLGIFSLVFLFNLVMLGAMVWEIRRQRKrgHKLKHTLVLLGLSLVLGIPWALAFFSFSSGsFQLVVVYLF 725
gi 602650049 565 ITkKEINNFLNLGYLSLVLFFNSIMLATMVYEILKLRHreHHWEYVVMLLGLSCVLGIPWGLAFFAFASGtFKLVAVYLF 644
                        250       260       270
                 ....*....|....*....|....*....|.
Feature 1        #                              
gi 68565559  638 SIITSFQGFLIFIWYWSMRlQARGGPSPLKS 668
gi 465970858 726 TIINTLQGFLIFLWYWTMVlQVRELNSYPSP 756
gi 602650049 645 TIINSLQGFLIFLWYLAKVlQSRRSSSMQCT 675

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