Conserved Protein Domain Family
7tmB2_GPR126

?
cd15996: 7tmB2_GPR126 
orphan adhesion receptor GPR126, member of the class B2 family of seven-transmembrane G protein-coupled receptors
GPR126 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR56, GPR64, GPR97, GPR112, and GPR114. GPR126 is required in Schwann cells for proper differentiation and myelination via G-Protein Activation. GPR126 is believed to couple to G(s)-protein, which leads to activation of adenylate cyclase for cAMP production. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.
Statistics
?
PSSM-Id: 320662
View PSSM: cd15996
Aligned: 4 rows
Threshold Bit Score: 513.281
Threshold Setting Gi: 215274152
Created: 1-Jul-2014
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative polypeptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on mutagenesis of human glucagon receptor (GCGR), and modeling studies of GCGR and other related class B GPCRs
  • Comment:Residues in the globular N-terminal extracellular domain and the extracellular loops of the 7TM domain may also be involved in ligand binding.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                #   #                                          #  ##  #        #      #  
gi 215274152  861 TKVLTFISYIGCGISAIFSAATLLTYVAFEKLRRDypSKILMNLSTALLFLNLLFLLDGWITsfnvdGLCIAVAVLLHFF 940
gi 290463239  848 NRVLTFITYIGCGISAIFSAATLLTYIAFEKLRRDypSKILMNLSTSLLFLNMVFLLDGWLAsyeikELCVTVAVFLHFF 927
gi 60099115   855 TKILTFITYIGCGISAIFSAATLLTYIAFEKLRRDypSKILMNLSTALLFLNLTFLLDGWIAsfdidGLCIAIAALLHYF 934
gi 512843060  506 SRILTFITYIGCGISAICTAATLLTYIAFEKIRRDypSKILMNLSTALLFLNLFFLLDGWIAsfginELCITVAVLLHFF 585
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 215274152  941 LLATFTWMGLEAIHMYIALVKVFNTYirRYILKFCIIGWGLPALVVSVVLASRnnnevygke------sygkekgdEFCW 1014
gi 290463239  928 LLTSFTWMGLESIHMYIALVKVFNTYirRYILKFCIVGWGVPAAIVGIVLAVSkdsygknyyg----kgkdgqgtsEFCW 1003
gi 60099115   935 LLATFTWMGLEAVHMYIALVKVFNTYirRYILKFCIIGWGLPALVIAIVLASTnknasrvygkelygrdatgqggdDFCW 1014
gi 512843060  586 LLATFTWMGLEAVHMYIALVKVFNTYirRYMLKFCIIGWGLPAIIVSVVLASThsniaygsssy--gqdsrgnggdEFCW 663
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               ## # #                                                      #  #          
gi 215274152 1015 IQdPVIFYVTCAGYFGVMFFLNIAMFIVVMVQICGRNGkrsnrtlreEVLRNLRSVVSLTFLLGMTWGFAFFAWGPlNIP 1094
gi 290463239 1004 ILnPVVFYVTCVAYFSIIFLMNVAMFIVVMIQICGRNGkrsnrtlreDILRNLRSVVSLTFLLGMTWGFAFFAWGPvSLA 1083
gi 60099115  1015 IKnKVVFYVTCAGYFGIMFLLNVAMFVVVMVQICGRNGkrtnrtlkeEILRNLRSVVSLTFLLGMTWGFAFFAWGPlTLP 1094
gi 512843060  664 IKsDTVFYVTCAAYFAIMFLMNVAMFIVVMVQICGRNGkrtnrsireEVLRNLRSVVSLTFLLGMTWGFAFFAWGPvNLA 743
                         250       260       270
                  ....*....|....*....|....*....|....*
Feature 1          #   #                             
gi 215274152 1095 FMYLFSIFNSLQGLFIFIFHCAMKeNVQKQWRQHL 1129
gi 290463239 1084 FMYLFTIFNSLQGLFIFVFHCALKeNVQKQWRRYL 1118
gi 60099115  1095 FLYLFSIFNSLQGLFIFVFHCAMKeNVQKQWRRHL 1129
gi 512843060  744 FMYLFTIFNSLQGLFIFVFHCALKeNVQKQWRRHL 778

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap