2KS9


Conserved Protein Domain Family
7tmA_NK1R

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cd16002: 7tmA_NK1R 
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neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.
Statistics
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PSSM-Id: 320668
View PSSM: cd16002
Aligned: 5 rows
Threshold Bit Score: 482.057
Threshold Setting Gi: 310942510
Created: 10-Dec-2014
Updated: 26-Jul-2017
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 41 residues -Click on image for an interactive view with Cn3D
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
2KS9_A        33 VLWAAAYTVIVVTSVVGNVVVMWIILAHKRmrtvTNYFLVNLAFAEASMAAFNTVVNFTYAvhneWYYGlfyCKFHNFFP 112
gi 45382375   37 ALWAVAYTLIVVVSVVGNVVVMWIILAHKRmrtvTNYFLVNLAFAEASMSAFNTVVNFTYAihneWYYGllyCKFHNFFP 116
gi 393198609  39 VLWAVAYSTIVVVSVVGNITVIWIILAHKRmrtvTNYFLVNLAFAEASMSAFNTVINFVYSvhneWYFGlyyCRFHNFFP 118
gi 2494983    34 ALWSVAYSIIVIVSLVGNIIVMWIIIAHKRmrtvTNYFLVNLAFAEASMSAFNTVINFTYAihnhWYYGliyCKFHNFFP 113
gi 557016216  45 ALWAIAYSVIVIIAVVGNIIVMWVILAHKRmrtvTNYFLVNLAFAEASMAAFNTVINFTYAshneWYYGheyCMFHNFFP 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                          # #####                           
2KS9_A       113 IAAVFASIYSMTAVAFDRYMAIIHPlqpRLSATATKVVICVIWVLALLLAFPQGYYsttetmpsrvVCMIEWPEhpn-ki 191
gi 45382375  117 IAAVFASIYSMTAIALDRYMAIIHPlqpRLSATATKVVICVIWLLAFLLAFPQGYYsvteelpgrlVCLVAWPEhst-dv 195
gi 393198609 119 IAAVFASIYSMTAIALDRYMAIIHPlqqRMSATQTKVVIGVIWILALLLAFPQYYYsdtdqlpgrvVCYIDWPEytl-ld 197
gi 2494983   114 ISAVFTSIYSMTAIALDRYMAIIHPlkpRLSATATKIVICVIWSFSFCMAFPLGYYadvypmeggdICYLNWPDseenrk 193
gi 557016216 125 ITAVFASIYSMTAIALDRYMAIIHPlkpRLPATATKIIICVIWVLASSLAFPLFYFskteeifgrfVCYVEWPE------ 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  ### ### ##                                                                  
2KS9_A       192 YEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGdssd------------ryheQVSAKRKVVKMMIVVVCTFAI 259
gi 45382375  196 YGKTYHFCMTVLIYFLPLLVIGCAYTVVSITLWASEIPGdssd------------ryheQVSAKRKVVKMMIIVVCTFAL 263
gi 393198609 198 FKTMYFVCVAVLIYFLPLLVMGCAYLVVGLTLWASEIPGdssd------------ryqeQLTAKRKVVKMMIVVVCTFAV 265
gi 2494983   194 YEQVYQVLVFCLIYILPLLVIGCAYTFIGMTLWASEIPGdssd------------ryheQVVAKRKVVKMMIVVVCTFAI 261
gi 557016216 199 QDTGFRESIEAGLYFGAVLTTVNVQCFVNIKQGPREIPQeeqrlqlqvgpdsaikrsgvSYLQRLHVVKMMIVVVCTFAI 278
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
Feature 1         #  ## ##  #           ## ###  #  ##                     
2KS9_A       260 CWLPFHIFFLLPyinpdlylkkFIQQVYLAIMWLAMSSTMYNPIIYCCLNdRFRLGF 316
gi 45382375  264 CWLPYHIYFTLQyfnpewylqkFIQQVYLAVMWLAMSSTMYNPIIYCCLNdRFRVGF 320
gi 393198609 266 CWLPYHVYFLIHqfyphlfehtFIQQVYLTIMWLAMSSTMYNPIIYCCLNdRFRAGF 322
gi 2494983   262 CWLPFHIFFLLQtlhe--mtqkFYQQFYLAIMWLAMSSTMYNPIIYCCLNdRFRIGF 316
gi 557016216 279 CWLPYHVYFLLQhfhpelyeqkFIQQVYLAIMWLAMSSTMYNPIIYCCLNdRFRVGF 335

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