Conserved Protein Domain Family
7tmA_NKR_NK3R

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cd16003: 7tmA_NKR_NK3R 
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.
Statistics
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PSSM-Id: 320669
View PSSM: cd16003
Aligned: 4 rows
Threshold Bit Score: 506.005
Threshold Setting Gi: 301610534
Created: 10-Dec-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 128364     86 ALWSLAYGVVVAVAVLGNLIVIWIILAHKRmrtvTNYFLVNLAFSDASMAAFNTLVNFIYAlhseWYFGanyCRFQNFFP 165
gi 301610534  50 ALWSLAYGSMVAVAVFGNIIVIWIILAHKRmrtvTNYFLVNLAFSDASMAAFNTLVNFIYAlhneWYFGeayCRFHNFFP 129
gi 591359114  62 ALWSLAYGGVVAVAVFGNLIVIWIILAHKRmrtvTNYFLVNLAFSDASMAAFNTVINFIYAlhseWYFGeayCRFHNFFP 141
gi 525345418  26 ALWSVAYSFVLAVAVFGNLIVIWIILAHKRmrtvTNYFILNLAFSDASMAAFNTLINFIYAahgeWYFGkayCKFHNFFP 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                          # #####                         # 
gi 128364    166 ITAVFASIYSMTAIAVDRYMAIIDPlkpRLSATATKIVIGSIWILAFLLAFPQCLYsktkvmpgrtlCFVQWPegpkqHF 245
gi 301610534 130 ITSIFASIYSMSAIAVDRYMAIIDPlkpRLSATSTKVVIGSIWIFAILLAFPQCLYskirvtrtrtlCMLVWPgk-deRL 208
gi 591359114 142 ITAVFASIYSMTAIAVDRYMAIIDPlkpRLSATVTKVVIGSIWILAFLLAFPQCLYsitkvmpgrtlCYVAWPggpkqHF 221
gi 525345418 106 VTSVFASIYSMTAIAVDRYMAIIHPlkpRLSAKATTGVIICIWSLAVVLAFPLCYFsttlvlphktvCFVAWPrsaddSF 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ### ### ##                                                       #  ## ##  #   
gi 128364    246 TYHIIVIILVYCFPLLIMGITYTIVGITLwggeipgdtcdkyheqlKAKRKVVKMMIIVVMTFAICWLPYHIYFILTaiy 325
gi 301610534 209 TYQFILVLLVYVLPLIVMGVTYTIVGITLwggeipgdtsdkyheqlRAKRKVVKMMIVVVVTFAICWLPYHIFFLADald 288
gi 591359114 222 TYHVIVIVLVYCFPLLVMGITYTIVGITLwggeipgdtsdkyheqlKAKRKVVKMMIVVVLTFAICWLPYHIYFIVTgiy 301
gi 525345418 186 MYHIIVIVLVYLLPLLVMAITYTIVGMTLwggeipgdssdnyhgqlRAKRKVVKMMIIVVLTFALCWLPYHVYFIVTgls 265
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
Feature 1                ## ###  #  ##                     
gi 128364    326 qqlnrwkyIQQVYLASFWLAMSSTMYNPIIYCCLNkrFRAGF 367
gi 301610534 289 ikldrwkyIQQIYLAIFWLAMSSTMYNPIIYCCLNkrFRAGF 330
gi 591359114 302 qhlnrwkyIQQIYLASFWLAMSSTMYNPIIYCCLNkrFRAGF 343
gi 525345418 266 kqlskqkyIQQVYLSVLWLAMSSTMYNPIIYCCLNsrFRAGF 307

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