Conserved Protein Domain Family
7tmA_SKR_NK2R

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cd16004: 7tmA_SKR_NK2R 
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.
Statistics
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PSSM-Id: 320670
View PSSM: cd16004
Aligned: 4 rows
Threshold Bit Score: 465.087
Threshold Setting Gi: 47218710
Created: 10-Dec-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 229462950  34 ALWATAYLALVLVAVTGNAIVIWIILAHRRmrtvTNYFIVNLALADLCMAAFNAAFNFVYAshniWYFGrafCYFQNLFP 113
gi 47218710    6 ALWAIAYSLIILVSITGNITVIWIILAHRRmrtvTNYFIVNLAFSDVSMASFNTLFNFVYAlhndWYFGlgyCRFQNFFP 85
gi 513190621  38 ALWAITYSFIVIASIVGNVTVIWIILAHRRmrtaTNYFIVNLALSDLLMSAFNTIFNFIYAshnvWYFGeefCRFQNWFP 117
gi 632972747  39 AVWTVAYALIVVTAVIGNLTVIWIILAHRRmrtvTNYFLVNLAFADASMGAFNTVFNFLYAthndWYFGleyCRFHNFFP 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                          # #####                           
gi 229462950 114 ITAMFVSIYSMTAIAADRYMAIVHPfqpRLSAPSTKAVIAGIWLVALALASPQCFYstvtmdqgatkCVVAWPedsggkt 193
gi 47218710   86 ITAMFSSIYSMAAISVDRYMAIIHPlkpRLSSTSTKVVIALIWVVAVCLAFPQCYYsvtrfyyprtvCMVDWPgdyggkh 165
gi 513190621 118 ITAMFVSIYSMTAVAAERYVAIIHPfkpRLSAGNTRVIIGIIWLVAFGLAFPQCFYaeimmdngttkCIVVWPddvgskh 197
gi 632972747 119 ITAIFASIYSMTAIAVDRYIAIIHPlkpRLSSGATKIMIGVIWLLALALAFPQCFYahvehrdtrtiCIVNWPgdiggqh 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ### ### ##                                                         #  ## ##  
gi 229462950 194 LLLYHLVVIALIYFLPLAVMFVAYSVIGLTLwrravpghq-ahganlrhlQAMKKFVKTMVLVVLTFAICWLPYHLYFIL 272
gi 47218710  166 QLSYQYAVILLIYLLPLLVMLVTYSIVGRSLwggqipgea--tdhyhsqiKAKRKVVKMMVVVVVTFALCWLPYHVYFIL 243
gi 513190621 198 QLTYHIAVIVLIYLLPLMVMFVTYSIIGITLwssavpgnhvnrvrykhqvNAKKKFVKTMVVVVIIFAVCWLPYHIYFIL 277
gi 632972747 199 QLTYQLAVIVLIYLMPLTVMGITYTKVGITLwaseipgds--seqyheqlSAKRKVVKMMIVVVVTFGICWLPYHFYFIL 276
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
Feature 1        #           ## ###  #  ##                     
gi 229462950 273 GsfqediychkfIQQVYLALFWLAMSSTMYNPIIYCCLNhrFRSGF 318
gi 47218710  244 GsfnidiykqhyIQQVYLAIFWLAMSSTMYNPIIYCCLNqrFRAGF 289
gi 513190621 278 GsfkediyqqkyIQQVYLTIFLLAMSSTMYNPIIYCCLNqrFRSGF 323
gi 632972747 277 GsfnndiyyetyMQQVYLAIFWLAMSSTMYNPIIYCCLNkrFRIGF 322

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