1I8L,1DR9


Conserved Protein Domain Family
IgC_CD80

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cd16083: IgC_CD80 
Click on image for an interactive view with Cn3D
Immunoglobulin constant (IgC)-like domain of antigen receptor CD80
Glycoproteins B7-1 (CD80) and B7-2 (CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (CD152) on T cells. Signalling through CD28 augments the T-cell response, whereas CTLA-4 signalling attenuates it. CD80 contains two Ig-like domains, an amino-terminal immunoglobulin variable (IgV)-like domain characteristic of adhesion molecules and a membrane proximal immunoglobulin constant (IgC)-like domain similar to the constant domains of antigen receptors. Members of the Ig family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and Major Histocompatibility Complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, and the IgC domain is involved in oligomerization and molecular interactions.
Statistics
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PSSM-Id: 319332
View PSSM: cd16083
Aligned: 11 rows
Threshold Bit Score: 170.331
Threshold Setting Gi: 585653431
Created: 22-Apr-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
intrachain IgC
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:intrachain IgC domain interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  #                         ####                        
1I8L_A       108 FPTPSISDFEiptsnIRRIICSTSggFPEPHLSWLEngeelnaiNTTVSQDPETELYAVSSKLDFNmttNHSFMCLIKYg 187
gi 461607    145 FSTPNITESGnpsadTKRITCFASggFPKPRFSWLEngrelpgiNTTISQDPESELYTISSQLDFNttrNHTIKCLIKYg 224
gi 1168850   141 FPVPSITDIGhpdpnVKRIRCSASggFPEPRLAWMEdgeelnavNTTVDQDLDTELYSVSSELDFNvtnNHSIVCLIKYg 220
1DR9_A       108 FPTPSISDFEiptsnIRRIICSTSggFPEPHLSWLEngeelnaiNTTVSQDPETELYAVSSKLDFNmttNHSFMCLIKYg 187
gi 30268720  144 FPVPNITQFGnqsadMKTIICETSggFPEPRSLWLEsgrelrgiNTTVSQDPESELYAVSSKLDFNatyNRSIVCSVAYg 223
gi 344257137  84 FPVPNITQFGepaadIKRIMCFASggFPKPRLTWLEdgkelsgiNTTVSQDPESQLYTVSSKLDFNmtyNHSIVCHIAYg 163
gi 504131106 220 FPSPSIVDVGdpvpnIKRIRCSASggFPEPHLSWWEdgel-savNTTVSQDLDTTLYTISSDLEFNvtkNHSIMCLIKYg 298
gi 674068363 142 FPVPVITELEdpfpdIKRIMCSTTggFPQPRLSWWEngtvltdiNTTISQDPETKLYNVTSEMDFNatyNHSIVCRVEYg 221
gi 562880081 142 FPTPSMTEFGttssnIRRINCSTSggFPEPRLSWLEdgkelnaiNTTVSQDPETELYAVSSYLDFSatsDHSFVCLVKYg 221
gi 585653431 151 FHDPVINELEstsngIKKILCSTSggFPKPHLSWLEngeeltagKTIIVPDLETELYTISSELLFNvtrNHTLVCLINYg 230
gi 617642654 142 FPEPSINDLGnpfpkIRRIKCSTSggFPKPHLSWWEndkelnatNTSVSQDPETELYSVNSELDFNvtdSHNFTCFVKYg 221
                         90
                 ....*....|.
Feature 1                   
1I8L_A       188 hLRVNQTFNWN 198
gi 461607    225 dAHVSEDFTWE 235
gi 1168850   221 eLSVSQIFPWS 231
1DR9_A       188 hLRVNQTFNWN 198
gi 30268720  224 kFEVSKNFTWK 234
gi 344257137 164 dSQVSKNFTWE 174
gi 504131106 299 dSRVSQTFTWH 309
gi 674068363 222 dSEVLKNFTWE 232
gi 562880081 222 dSTISQTFHWQ 232
gi 585653431 231 dKQVSKNISLV 241
gi 617642654 222 nSTVSHNYHWQ 232

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