4I2X,2WNG


Conserved Protein Domain Family
IgC_SIRP_domain_3

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cd16085: IgC_SIRP_domain_3 
Click on image for an interactive view with Cn3D
Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
Immunoglobulin (Ig)-like domain in Signal-Regulatory Protein (SIRP), domain 3 (C1 repeat 2). The SIRPs belong to the "paired receptors" class of membrane proteins that comprise several genes coding for proteins with similar extracellular regions but very different transmembrane/cytoplasmic regions with different (activating or inhibitory) signaling potentials. They are commonly on NK cells, but are also on many myeloid cells. Their extracellular region contains three Immunoglobulin superfamily domains a single V-set and two C1-set IgSF domains. Their cytoplasmic tails that contain either ITIMs or transmembrane regions that have positively charged residues that allow an association with adaptor proteins, such as DAP12/KARAP, containing ITAMs. There are 3 distinct SIRP members: alpha, beta, and gamma. SIRP alpha (also known as CD172a or SRC homology 2 domain-containing protein tyrosine phosphatase substrate 1/Shps-1) is a membrane receptor that interacts with a ligand CD47 expressed on many cells and gives an inhibitory signal through immunoreceptor tyrosine-based inhibition motifs in the cytoplasmic region that interact with phosphatases SHP-1 and SHP-2. SIRP beta has a short cytoplasmic region and associates with a transmembrane adapter protein DAP12 containing immunoreceptor tyrosine-based activation motifs to give an activating signal. SIRP gamma contains a very short cytoplasmic region lacking obvious signaling motifs but also binds CD47, but with much less affinity.
Statistics
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PSSM-Id: 319334
View PSSM: cd16085
Aligned: 15 rows
Threshold Bit Score: 190.32
Threshold Setting Gi: 488582671
Created: 22-Apr-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
intrachain IgC
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:intrachain IgC domain interface [polypeptide binding site]
Evidence:
  • Structure:4I2X: human SIPR gamma C1 and C2 domains form an intrachain IgC domain interface, contacts at 4A
    View structure with Cn3D
  • Structure:2WNG: human SIPR alpha C1 and C2 domains form an intrachain IgC domain interface, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##                         ##      ####             ###                         
4I2X_E       222 VPPTLEVTQQPMRvgnqVNVTCQVRKFYPQSLQLTWSENgnvcqretASTLTENKdg---------tYNWTSWFLVNIsd 292
gi 29427383  253 VSPTLKITQQPLTpasqVNLTCQVQKFYPKALQLNWLENgnls-rtdKPEHFTDNrd--------gtYNYTSLFLVNSsa 323
gi 29427667  253 VSPTVKVTQQSPTsmnqVNLTCRAERFYPEDLQLIWLENgnvs-rndTPKNLTKNtd--------gtYNYTSLFLVNSsa 323
gi 38175079  250 VPPTLEISQQPTMvwnvIIGTCQIQKFYPPRFQVTWLENgnis-rreVPFTLIVNkd--------gtYNWISCLLVNVsa 320
gi 524925060 345 VPPTLEMSQQPSEvrnlTYIACHVKKFYPLRLRLSWFENgnis-rieEPSTFTVNkd--------gtYSWNTWLLLKTsa 415
gi 532008925 248 VSPTLEISEQPSViwnlIGVTCQVNKFYPSKLRLTWIENgnis-hteDPSTFTVNkd--------gtYSWTSWHIVNVsa 318
gi 532045787 250 VSPILDVTEQSTStgnqANVTCRVQKFFPNKLRLIWLENgnvs-rtdEALNATVNgd--------gtYNWTSCLLVNKsa 320
gi 537146255 250 VSPSLDVTQQPTMaenqLNVTCHVQKFYPNKLKLIWLENgni--sriENSSIPVNntysqtvnkdgtYNWTSWLLVNKsa 327
gi 562869050  96 VPPLLEVTQHPMMtgnpLIITCHVEKFYPQDLQLTWLENgnvs-rteTTSTLTENkd--------gtYNLTSWLLLTPss 166
gi 674043539 250 VPPILEVSQQPTMvwslVNITCQVKXFYPLHLQVTWWENrnvs-rteKASVLTLNkd--------gtYNWLSWLLVNTsa 320
                         90       100       110
                 ....*....|....*....|....*....|...
Feature 1                    ## #                 
4I2X_E       293 qRDDVVLTCQVKHDGQlAVSKRLALEVSTRHHH 325
gi 29427383  324 hREDVVFTCQVEHDSQpAITENHTVRAFAHSSS 356
gi 29427667  324 hREDVVFTCQVKHDQQpAITRNHTVLGLAHSSD 356
gi 38175079  321 lEENMVVTCQVEHDGQaEVIETHTVVVTEHQRV 353
gi 524925060 416 qEGNLVVTCQVEHDGQpPIIKTHTVVVNEKQKE 448
gi 532008925 319 hEEDIILTCQVEHDQQpQEITTHTVMVSAHQRE 351
gi 532045787 321 hRENVVVTCQVDHDGK-PAIAKNYTVRVLHQKE 352
gi 537146255 328 yRENVVFTCQVEHDGKlVGTKNHTVLILAQQKE 360
gi 562869050 167 yREGMVLTCKVEHDGQpEITRSHTLEFSTQPKG 199
gi 674043539 321 hKKDIMLTCQVEHDGQpAVTRNHTLMVSEYQKM 353

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