1I8L,1DR9


Conserved Protein Domain Family
IgV_CD80

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cd16086: IgV_CD80 
Click on image for an interactive view with Cn3D
Immunoglobulin variable domain (IgV) in CD80
Glycoproteins B7-1 (CD80) and B7-2 (CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (CD152) on T cells. Signalling through CD28 augments the T-cell response, whereas CTLA-4 signalling attenuates it. CD80 contains two Ig-like domains, an amino-terminal immunoglobulin variable (IgV)-like domain characteristic of adhesion molecules and a membrane proximal immunoglobulin constant (IgC)-like domain similar to the constant domains of antigen receptors. Members of the Ig family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and Major Histocompatibility Complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, and the IgC domain is involved in oligomerization and molecular interactions.
Statistics
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PSSM-Id: 319335
View PSSM: cd16086
Aligned: 10 rows
Threshold Bit Score: 193.051
Threshold Setting Gi: 585653431
Created: 24-Apr-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
B7-1/CTLA-4homodimer
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:B7-1/CTLA-4 complex [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                    # # #  #  #        #             #                  
1I8L_A         1 VIHVTKEVKEVATLSCGHNVSVeeLAQTRIYWQKEKK-MVLTMMsgDMNIwpeyknRTIFDITnNLSIVILalrpsdEGT 79
1DR9_A         1 VIHVTKEVKEVATLSCGHNVSVeeLAQTRIYWQKEKK-MVLTMMsgDMNIwpeyknRTIFDITnNLSIVILalrpsdEGT 79
gi 461607     39 DEQLSKSVKDKVLLPCRYNSPHedESEDRIYWQKHDK-VVLSVIagKLKVwpeyknRTLYDNT-TYSLIILglvlsdRGT 116
gi 1168850    34 ISQVTKSVKEMAALSCDYNISIdeLARMRIYWQKDQQ-MVLSIIsgQVEVwpeyknRTFPDIInNLSLMILalrlsdKGT 112
gi 30268720   36 IGQVFKSVNEKVSLSCGYNFSFdeLAIHRIYWQKDDRkMVLSISsgDKKVwpeyqnRTLCDISnNFSLMILgllpsdRGT 115
gi 504131106 113 INQVTKSVNEMAALSCDYNISVseLVNMRIYWQKDQQ-MVLSIIseQVEVwpeyknRTFPDIInNLSLVILalrlsdKGT 191
gi 674068363  35 LGQVSKSVREMASLSCGYNISLdeLDRARVYWQKDGT-MVLAIIsgMVKVwpeyknRTFSDIAnNLSLVILglhlsdGGT 113
gi 562880081  35 FKQVTKAVKEVALLSCDYNVSPeqLASVRIYWQRGDA-TVLTVIsgQKEVwpeyrnRTTIDLTnNLSIVILalrlsdRGQ 113
gi 585653431  44 NSQIIKSVKEIAVLPCDYNVPDnqLKNFRIYWQTNEE-VVLTIMsgKVSKepkylnRTLVDIPrNLSIIILnlrpsdTGT 122
gi 617642654  35 YIQVTKTVKEKAILSCNYNITTdeLKQVRIYWQKEKD-LVLTVVegVVKVwsnyknRTIHILSdNPSIMILalrlsdNGI 113
                         90       100
                 ....*....|....*....|....*.
Feature 1           # #      ###           
1I8L_A        80 YECVVLKYEkdAFKREHLAEVTLSVK 105
1DR9_A        80 YECVVLKYEkdAFKREHLAEVTLSVK 105
gi 461607    117 YSCVVQKKErgTYEVKHLALVKLSIK 142
gi 1168850   113 YTCVVQKNEngSFRREHLTSVTLSIR 138
gi 30268720  116 YECVVQKKErgVYLLRHLNSVELSIR 141
gi 504131106 192 YTCVVQKSEngVFEVVHLTSVTLLIR 217
gi 674068363 114 YTCVVQRSDrgPYRVEHLKSVTLSIR 139
gi 562880081 114 YTCVVQKLEkgAYKLKHLTSVMLKVT 139
gi 585653431 123 YTCVVLKNEkgYFKREHLVSVDLLVR 148
gi 617642654 114 YTCVIQKMErgSYKRKHLMNVVLSVR 139

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