1I8L,1DR9


Conserved Protein Domain Family
IgV_CD80

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cd16086: IgV_CD80 
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Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 80
The members here are composed of the immunoglobulin variable region (IgV) in the Cluster of Differentiation (CD) 80). Glycoproteins B7-1 (also known as cluster of differentiation (CD) 80) and B7-2 (also known as CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (also known as cluster of differentiation 152/CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. CD80 contains two Ig-like domains, an amino-terminal immunoglobulin variable (IgV)-like domain characteristic of adhesion molecules and a membrane proximal immunoglobulin constant (IgC)-like domain similar to the constant domains of antigen receptors. Members of the Ig family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and Major Histocompatibility Complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, and the IgC domain is involved in oligomerization and molecular interactions.
Statistics
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PSSM-Id: 319335
Aligned: 10 rows
Threshold Bit Score: 193.051
Created: 24-Apr-2015
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:B7-1/CTLA-4 complex [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    # # #  #  #        #             #                  
1I8L_A         1 VIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKK-MVLTMMSGDMNIWPEYKNRTIFDITnNLSIVILALRPSDEGT 79  human
1DR9_A         1 VIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKK-MVLTMMSGDMNIWPEYKNRTIFDITnNLSIVILALRPSDEGT 79  human
Q00609        39 DEQLSKSVKDKVLLPCRYNSPHEDESEDRIYWQKHDK-VVLSVIAGKLKVWPEYKNRTLYDNT-TYSLIILGLVLSDRGT 116 house mouse
P42070        34 ISQVTKSVKEMAALSCDYNISIDELARMRIYWQKDQQ-MVLSIISGQVEVWPEYKNRTFPDIInNLSLMILALRLSDKGT 112 rabbit
AAP29471      36 IGQVFKSVNEKVSLSCGYNFSFDELAIHRIYWQKDDRkMVLSISSGDKKVWPEYQNRTLCDISnNFSLMILGLLPSDRGT 115 Mongolian gerbil
XP_004578338 113 INQVTKSVNEMAALSCDYNISVSELVNMRIYWQKDQQ-MVLSIISEQVEVWPEYKNRTFPDIInNLSLVILALRLSDKGT 191 American pika
XP_008841210  35 LGQVSKSVREMASLSCGYNISLDELDRARVYWQKDGT-MVLAIISGMVKVWPEYKNRTFSDIAnNLSLVILGLHLSDGGT 113 Upper Galilee m...
XP_006167708  35 FKQVTKAVKEVALLSCDYNVSPEQLASVRIYWQRGDA-TVLTVISGQKEVWPEYRNRTTIDLTnNLSIVILALRLSDRGQ 113 Chinese tree shrew
XP_006884381  44 NSQIIKSVKEIAVLPCDYNVPDNQLKNFRIYWQTNEE-VVLTIMSGKVSKEPKYLNRTLVDIPrNLSIIILNLRPSDTGT 122 Cape elephant s...
XP_007532177  35 YIQVTKTVKEKAILSCNYNITTDELKQVRIYWQKEKD-LVLTVVEGVVKVWSNYKNRTIHILSdNPSIMILALRLSDNGI 113 western Europea...
Feature 1           # #      ###           
1I8L_A        80 YECVVLKYEKDAFKREHLAEVTLSVK 105 human
1DR9_A        80 YECVVLKYEKDAFKREHLAEVTLSVK 105 human
Q00609       117 YSCVVQKKERGTYEVKHLALVKLSIK 142 house mouse
P42070       113 YTCVVQKNENGSFRREHLTSVTLSIR 138 rabbit
AAP29471     116 YECVVQKKERGVYLLRHLNSVELSIR 141 Mongolian gerbil
XP_004578338 192 YTCVVQKSENGVFEVVHLTSVTLLIR 217 American pika
XP_008841210 114 YTCVVQRSDRGPYRVEHLKSVTLSIR 139 Upper Galilee mountains blind mole rat
XP_006167708 114 YTCVVQKLEKGAYKLKHLTSVMLKVT 139 Chinese tree shrew
XP_006884381 123 YTCVVLKNEKGYFKREHLVSVDLLVR 148 Cape elephant shrew
XP_007532177 114 YTCVIQKMERGSYKRKHLMNVVLSVR 139 western European hedgehog

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