1I85,1I85,1NCN


Conserved Protein Domain Family
IgV_CD86

?
cd16087: IgV_CD86 
Click on image for an interactive view with Cn3D
Immunoglobulin variable domain (IgV) in CD86
Glycoproteins B7-1 (CD80) and B7-2 (CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (CD152) on T cells. Signalling through CD28 augments the T-cell response, whereas CTLA-4 signalling attenuates it. The CTLA-4 and B7-2 monomers are both two-layer beta-sandwiches that display the chain topology characteristic of the immunoglobulin variable (V-type) domains present in antigen receptors. The front and back sheets of B7-2 are composed of AGFCC'C" and BED strands, respectively. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.
Statistics
?
PSSM-Id: 319336
View PSSM: cd16087
Aligned: 19 rows
Threshold Bit Score: 171.745
Threshold Setting Gi: 83722002
Created: 24-Apr-2015
Updated: 18-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
 
homodimerB7-2L1L2L3
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                   ### #        #  ##         ##        
1I85_A         4 IQAYFNETADLPCQFANSQNqslsELVVFWQDQeNLVLNEVYLGKEKFdsvhskyMGRTSFDSDSWTLRLHNLQikdkGL 83
1NCN_A         4 IQAYFNETADLPCQFANSQNqslsELVVFWQDQeNLVLNEVYLGKEKFdsvhskyMGRTSFDSDSWTLRLHNLQikdkGL 83
gi 21217731   28 IQAYFNSTACLPCPHSKVQNmslsELVVFWQDQkKLVLYEHYLGREKSnsvnakyLGRTSFDEHNWALRLPNVQitdmGS 107
gi 74192559   28 TQAYFNGTAYLPCPFTKAQNislsELVVFWQDQqKLVLYEHYLGTEKLdsvnakyLGRTSFDRNNWTLRLHNVQikdmGS 107
gi 83722002   24 VKSFLNHTAYLSCYFPNSQKtdinNVIVFWQKGtGEVVHEVYLGQEKHdhlnskyINRTKMDMDKWTLQLLNVGivdeGQ 103
gi 395519097  26 IEAFFNKTTKLPCNFKNPQNigpeELVIFWQGGrDCVLYEFYRGKENLmyvnskyINRTKLNPNTWVLQLQNVQimdqGT 105
gi 505795565   3 SLVYFNETGKLFCNFPNSQNlswnELVIFWQDQdMLVLFDLLQGIEQPksvnskyKGRTSFDRDSWTLKLHNVQiqdkGT 82
gi 507928493  22 SQAYFGDTGLLPCRFKNPQNtsldELVVFWQNQ-DKVLYELYTGSENPhnvhpmyKGRTSFDLGSWTLKLHNIEikdeGT 100
gi 557292175   4 EKAFVNHTAYLRCNFHNPDNidvkELIVFWQKE-SEVVNEVYRGQELSdnldpkyINRTMMDMNTWTLCLLNVGimdeGQ 82
gi 558134843  52 SQAYFNKIGDLPCHFTNPENisldELVVFWQNQdKLVLYELFRGKENLqsvdanyKDRTSLDQDNWTLRLHNIQikdkRL 131
                         90       100
                 ....*....|....*....|....*..
Feature 1                                   
1I85_A        84 YQCIIHHKKp-TGMIRIHQMNSELSVL 109
1NCN_A        84 YQCIIHHKKp-TGMIRIHQMNSELSVL 109
gi 21217731  108 YDCYIQQKRp-TGSVILQQTNMELSVV 133
gi 74192559  108 YDCFIQKKPp-TGSIILQQTLTELSVI 133
gi 83722002  104 YKCIIMHVD--KGPKKLIHESECLLNI 128
gi 395519097 106 YTCFVQHYGs-KGPVVIHQFSFQLSVF 131
gi 505795565  83 YTCFIHHKKp-GGMIPLFQMNSELSVR 108
gi 507928493 101 YYCYVHHKQrnIGMVPIYQMGFYLSVL 127
gi 557292175  83 YVCIIQHKKs-SGLEKIYDSKSQLFVI 108
gi 558134843 132 YQCFIYHRKnlQGMNLIHQNDIDLSVL 158

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap