2JJS,4KJY


Conserved Protein Domain Family
IgV_CD47

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cd16090: IgV_CD47 
Click on image for an interactive view with Cn3D
Immunoglobulin variable domain (IgV) in CD47
CD47 also known as integrin associated protein (IAP), partners with membrane integrins and binds thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRP alpha). It is involved in apoptosis, proliferation, adhesion, migration, and immune and angiogenic responses. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.
Statistics
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PSSM-Id: 319339
View PSSM: cd16090
Aligned: 26 rows
Threshold Bit Score: 168.952
Threshold Setting Gi: 565312569
Created: 22-Apr-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
SIRP-CD47
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:SIRP-CD47 complex [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                     # # #                                              
2JJS_C         8 KSVEFTfGNDTVVIPCFVTNmeaqnttEVYVKWKfkGRDIYTFDgaLNKSTVpTDFSSAKie-vSQLLKGDASLKMdKSD 86
4KJY_A         8 KSVEFTfGNDTVVIPCFVTNmeaqnttEVYVKWKfkGRDIYTFDgaLNKSTVpTDFSSAKie-vSQLLKGDASLKMdKSD 86
gi 37928747   26 DFVEKYaCNDTVVLPCIVTNlkenndsSMHVSWKrqGQVIFSFNgpEQRIYRhESVPSANflskADLFKGIASLRLkNAE 105
gi 558133394   6 KSVESSiCNTTVMLPCIVNNlelkrteRMFIKWKlgQELVFAYEgiKRYSHRtKDFPSAMlafeDRLPQGIASLKLsRTE 85
gi 591365514  36 KSVEQTiCNETVILPCIVTNlaqknikVMFVKWKleKNEFFSFDgsTGKTDRnKNFSSAVlesvQNLSLGSASLSIsKTQ 115
gi 620965965  77 RLVEKNaCNHSVLLPCSVTNielnnirAMFVRWKykGRDIYTFDgfQDKVTIsNDFQSASif-vPDILSGNSSLRLsDDD 155
gi 676413976  11 GVIEKNdCNETVVLPCYVTNlkennenLMLVTWKkqGDIIFSYHggKKEFNInPSFSSARllsqPDLIKGVASLVLsSAQ 90
gi 676584053  11 SPVESTsCNRTVTLPCYVVDlkltsakGMFVTWQkhDKLIFSYDgaTQEFFRdPVVPSANlaslVDLPKGVASLTFkNGE 90
gi 677150164  11 DPVEINnCNKTVLLPCYVNNlrennvhVMFIRWRkgREKVLSFDgeNEKTVV-KVPSARLpp-vADILKGNASLTLnSAE 88
gi 677435517  11 DVVERTiCNKTVILPCYVTNlkennasVMFVTWKkqGKRIFSFDggKVEFFKdPAFSSANlvsqADLPKGVASLTLnSAE 90
                         90       100
                 ....*....|....*....|....*....
Feature 1                  #        #         
2JJS_C        87 AVshtGNYTCEVteltrEGETIIELKYRV 115
4KJY_A        87 AVshtGNYTCEVteltrEGETIIELKYRV 115
gi 37928747  106 APd--GNYSCEVtelnrEGETKMKLRTHM 132
gi 558133394  86 APa--GNYTCEVtesnrEGETIIELTYRQ 112
gi 591365514 116 AVp--GNYSCEVtesnrEGETVIELIYHR 142
gi 620965965 156 AVl--GNYTCEVteanrEGEIIVELRYHV 182
gi 676413976  91 ATv--GNYSCEViesnsVGEIKMELRNSS 117
gi 676584053  91 GVd--GNYSCKVtvsnsEGKITVELRSIT 117
gi 677150164  89 ADi--ANYSCEVtesnrEGAVTVEIRNRS 115
gi 677435517  91 ADa--GNYSCEVtessrEGETRVELRNHT 117

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