3KHQ,3KG5


Conserved Protein Domain Family
IgV_CD79b_beta

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cd16096: IgV_CD79b_beta 
Click on image for an interactive view with Cn3D
Immunoglobulin variable domain (IgV)
IgV: Immunoglobulin variable domain (IgV) in CD79B (Cluster of Differentiation 79B). Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.
Statistics
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PSSM-Id: 319345
View PSSM: cd16096
Aligned: 5 rows
Threshold Bit Score: 160.117
Threshold Setting Gi: 304445810
Created: 2-May-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #                           #                                       #           
3KHQ_A        25 RFAAKKRSSMVKFHCYTnh-sGALTWFRKrgs-qqPQELvseegrIVQTQNgsVYTLTIQniqyednGIYFCKQKcdsan 102
gi 6680375    51 RFAAKKRSSMVKFHCYTnh-sGALTWFRKrgs-qqPQELvseegrIVQTQNgsVYTLTIQniqyednGIYFCKQKcdsan 128
gi 19424188   51 RFAAKKRSSMVKFHCHTdy-sGVMTWFRQkgn-qrPQELfpedghISQTRNgsVYTLTLQniqyednGIYFCQQKcnste 128
gi 149054577 112 RFAAKKRSSMVKFHCHTdy-sGVMTWFRQkgn-qrPQELfpedghISQTRNgsVYTLTLQniqyednGIYFCQQKcnste 189
3KG5_A        26 RFIARKRGFTVKMHCYMnsasGNVSWLWKqemdenPQQLklekgrMEESQNesLATLTIQgirfednGIYFCQQKcnn-t 104
                         90
                 ....*....|...
Feature 1         #### ## #   
3KHQ_A       103 hNVTDSCGTELLV 115
gi 6680375   129 hNVTDSCGTELLV 141
gi 19424188  129 pDVTDGCGTELLV 141
gi 149054577 190 pDVTDGCGTELLV 202
3KG5_A       105 sEVYQGCGTELRV 117

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