Conserved Protein Domain Family
EFh_MICU2

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cd16174: EFh_MICU2 
EF-hand, calcium binding motif, found in calcium uptake protein 2, mitochondrial (MICU2) and similar proteins
MICU2, also termed EF-hand domain-containing family member A1 (EFHA1), is a mitochondrial-localized paralog of MICU1. MICU2 and its paralog, MICU1, are physically associated within the mitochondrial calcium uniporter (MCU) complex and are co-expressed across all tissues. They may operate together with MCU to regulate the channel. At present, the precise molecular function of MICU2 remains unclear. It may play possible roles in Ca2+ sensing and regulation of MCU, calcium buffering with a secondary impact on transport or assembly and stabilization of MCU. MICU2 contains an N-terminal mitochondrial targeting sequence (MTS) as well as two evolutionarily conserved canonical Ca2+-binding EF-hands separated by a long stretch of residues predicted to form alpha-helices.
Statistics
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PSSM-Id: 320082
View PSSM: cd16174
Aligned: 4 rows
Threshold Bit Score: 231.683
Threshold Setting Gi: 339895805
Created: 19-Nov-2014
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Feature 1:Ca binding site [ion binding site]
Evidence:
  • Comment:Based on the structure evidence that human MICU1 binds two Ca2+ ions through its EF-hands.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 # # #      #                                                           
gi 115502157 176 GFHVAFKMLDTDGNEMIEKREFFKLQKIISkqddlmtvktnetgyqeaivkepeintTLQMRFFGKRGQRKLHYKEFRRF 255
gi 678992128  47 GFQIAFKMLDTDGNEQVEKKEFFKLQRIIGkeddlktsgdetv-srgaelescgvntTLLVHFFGKEGKEKLRYSEFFRF 125
gi 339895805 167 GFHIAFKMLDIDGSETVDKMEFQKLKKVNGpkkellrqggt-----elsdnadevdtTLQVFFFGKDGNKKLQYKDFCRF 241
gi 82225765  171 GFGIAFKMLDTDGNEQVEKREFFKLQRILGhkedmmmgpggvtstqepssdssdvntTLLVHFFGRGGREKLQYSEFYKF 250
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 115502157 256 MENLQTEIqemeflqfskglsfmrkedfaewllfftntenkdiywknvreklsagesisldefksfchftthlEDFAIAM 335
gi 678992128 126 MENLQTEVqemefikfskglnvmrkedfaewllyftdeenneiywqnvkdrieagenisleefktfckftnnlEDFSIAM 205
gi 339895805 242 MEDLQAEVqeveftqfskgmktmrredfaewllhftneedneayqdnmrkriptgqsitfdefkefclftyhlEDFAISV 321
gi 82225765  251 MENLQTEVqemefiqfskglnfmrkedfaewllfftdeenndmywqnvqarippgesismdefksfylfmnnlEDFSITM 330
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                               # # #      #         
gi 115502157 336 QMFSLAHRPVRLAEFKRAVKVATgqelsnnILDTVFKIFDLDGDECLSHEEFLGVLKNRM 395
gi 678992128 206 QMFTVANRPVKRAEFKRAVKVATgqelsdnVLDTIFKIFDLDGDDCLSHGEFLGVLRNRI 265
gi 339895805 322 KMSIEGSKPIGLAQFKRAVMIATghelsdnVLDTVFKLFDMDGDDCLSHKEFLAVMKDRV 381
gi 82225765  331 KMFSSANRAIKMAEFKRAVKVATgqelsnnVLDTVFKIFDLDGDNCLSHGEFLGVLRNRL 390

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