Conserved Protein Domain Family
EFh_PEF_CAPN11

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cd16193: EFh_PEF_CAPN11 
Penta-EF hand, calcium binding motifs, found in calpain-11 (CAPN11)
CAPN11, also termed calcium-activated neutral proteinase 11 (CANP 11), is a mammalian orthologue of micro/m calpain. It is one of the calpain large subunits that appears to be exclusively expressed in certain cells of the testis. It may be involved in regulating calcium-dependent signal transduction events during meiosis and sperm functional processes. CAPN11 contains a short N-terminal anchor helix, followed by a calpain cysteine protease (CysPc) domain, a C2-domain-like (C2L) domain, and a C-terminal Ca2+-binding penta-EF-hand (PEF) domain.
Statistics
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PSSM-Id: 320068
View PSSM: cd16193
Aligned: 3 rows
Threshold Bit Score: 319.943
Threshold Setting Gi: 218511961
Created: 13-Feb-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
  next features
Feature 1:putative Ca binding site [ion binding site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus m-calpain (3DF0) binds four Ca2+ ions through its EF1, EF2, EF3, and EF4 hands.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    # #    #                 #              # # #      #                
gi 218511961 571 DFLHLFKIVAGEGKEIGVYELQRLLNRMAikfksFKTKGFGldACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFR 650
gi 81863795  547 DSLQLFKIMANEDGEVDMYALHKLLNRMTaklrnFKTKGFSleVCRRMINLLDKDGSGKLELHEFQVLWKKIKKWTEIFK 626
gi 218563524 548 NSVELFETLANRDSQVDMYDLQKLLNKMSskvksFKSKGFSldVCRRMVNLMDKDDSGKLGLHEFHILWKKIKKWMEIFK 627
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          # # #      #                               # ##                               
gi 218511961 651 ECDQDHSGTLNSYEMRLVIEKAGIklnnkVMQVLVARYADdDLIIDFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLE 730
gi 81863795  627 ECDEDRSGNLNSYEMRLAIEKAGIkmnnrVTEVVVARYSD-NMIVDFDSFLNCFLRLKAMFAFFLSMDTKKTGSICLDIN 705
gi 218563524 628 ECDQDRSGNLNSYEMRLAIEKAGIrmnnrVTEVVVARYADaNMIVDFDNFINCFLRLKAMFAFFLSMDTKKTGSICLNIN 707

                 ....*....
Feature 1                 
gi 218511961 731 QWLQMTMWG 739
gi 81863795  706 QWLQITMWG 714
gi 218563524 708 QWLHITMWG 716

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