Conserved Protein Domain Family
EFh_PEF_CAPN12

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cd16194: EFh_PEF_CAPN12 
Penta-EF hand, calcium binding motifs, found in calpain-12 (CAPN12)
CAPN12, also termed calcium-activated neutral proteinase 12 (CANP 12), is a calpain large subunit mainly expressed in the cortex of the hair follicle. It may affect apoptosis regulation. CAPN12 contains a short N-terminal anchor helix, followed by a calpain cysteine protease (CysPc) domain, a C2-domain-like (C2L) domain, and a C-terminal Ca2+-binding penta-EF-hand (PEF) domain.
Statistics
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PSSM-Id: 320069
View PSSM: cd16194
Aligned: 3 rows
Threshold Bit Score: 305.263
Threshold Setting Gi: 54035703
Created: 13-Feb-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
  next features
Feature 1:putative Ca binding site [ion binding site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus m-calpain (3DF0) binds four Ca2+ ions through its EF1, EF2, EF3, and EF4 hands.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    # #    #                   #              # # #      #              
gi 54035703  551 GLEQLFQELAGEEEELNASQLQALLSIALeparAHTSTPREIGlrTCEQLLQCFGHGQS--LALHHFQQLWGYLLEWQAI 628
gi 641776335 428 EVENIFLQFAGQDQEIGVVELKKILAVTLa--rEADSKPERFQleTCRQMIRLFDYSKNgrLSLEEFKTLWERLREWKAI 505
gi 159156042 519 EFTAHFTRLSGLDREISPEELQKILVQITs--kHTHLKVDGFPldTCRLLIKMVDRNGNgkLQLEEFRKLWTKIKEWEQI 596
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            # # #      #                               # ##                             
gi 54035703  629 FNKFDEDTSGTMNSYELRLALNAAGFhlnnqLTQTLTSRYRDSRLRVDFERFVSCVAHLTcIFCHCSQHLDGGEGVICLT 708
gi 641776335 506 FTEHDRDKSGNMDAYEMRLALATAGFhlnnqFCEIITNQYRNRGLFIDLNSFLSCLAHLTwIFRQCKTRDRDGTGIVTMA 585
gi 159156042 597 FTKYDKDRSGTMDVQELRLALEAAGFtlnnqLVESLCQRYGDDVRQVDFDSFLSCLAYLVcVFGQCQNMDQNKDGLISIS 676
                        170
                 ....*....|.
Feature 1                   
gi 54035703  709 HRQWMEVATFS 719
gi 641776335 586 HKEWLELITAT 596
gi 159156042 677 KQQWLQLLCFN 687

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