2I7A


Conserved Protein Domain Family
EFh_PEF_CAPN13_14

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cd16195: EFh_PEF_CAPN13_14 
Click on image for an interactive view with Cn3D
Penta-EF hand, calcium binding motifs, found in calpain-13 (CAPN13), calpain-14 (CAPN14), and similar proteins
CAPN13, also termed calcium-activated neutral proteinase 13 (CANP 13), a 63.6 kDa calpain large subunit that exhibits a restricted tissue distribution with low levels of expression detected only in human testis and lung. In calpain family, CAPN13 is most closely related to calpain-14 (CAPN14). CAPN14, also termed calcium-activated neutral proteinase 14 (CANP 14), is a 76.7 kDa calpain large subunit that is most highly expressed in the oesophagus. Its expression and calpain activity can be induced by IL-13. Both CAPN13 and CAPN14 contain a calpain cysteine protease (CysPc) domain, a C2-domain-like (C2L) domain, and a C-terminal Ca2+-binding penta-EF-hand (PEF) domain.
Statistics
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PSSM-Id: 320070
View PSSM: cd16195
Aligned: 29 rows
Threshold Bit Score: 203.205
Threshold Setting Gi: 512863605
Created: 19-Feb-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca binding site [ion binding site]
Evidence:
  • Structure:2I7A; Homo sapiens calpain-13 binds a Ca2+ ion.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #   #      #             
2I7A_A         6 HHHHHSSGLVPRGSDIDATQLQGLLNQELlt-----gpPGDMFSLdECRSLVALMELKVNGRLDQEEFARLWKRLVHYQH 80
gi 512863605 507 QCHSRFLLFSDQDGRITNEGLHHLLTSLMkdf----dpLLPEITMeSCCRLIASLDTSAEGALCWEQFDRLWKNIITGSL 582
gi 573878768 497 VARELFMKHAAAGGRCGAVELQGLLKEVIvtga--lagSREGFCLeRCKSFVALMDTRGLGRLEMEEFEALWEKFRKWTD 574
gi 47086161  502 EARDLFVKHCAKGPYCRPLDLYNLLTEAIskgv--fagSEKMLSLeHCKSFVVLMDSQGMGRLDLTEFQALWDKLRKWTS 579
gi 637257930 429 SYKTIFLKYANQSSFLDASQLQRILNEVLlkdlmasqgSGNRFSFdSSKSLLALMDINANGRLSLDEFGELWRELNIYKD 508
gi 641753159 518 ASENIFLRYATQGSDLNASQLQRLLNEVFlkdr--lasPGGGFCFeSCRGILALMDLKSNGRLSLQEFKHLWKLLAQYKD 595
gi 148227390 593 GYEKVFIRYCNKSSELYAEQLQKLLNEVLikdq-tfnaSRGDFTLdACRGILMLMDLNANGRLNLQEFERLWKRLSMCKD 671
gi 513174287 550 SYKAIFLKYAKQGSAIDALQLQRLLNDMVlqde--mtsVGGEFSFdSCRAILALMDLNSNGQLTLQEFGSLWRSVTKYMD 627
gi 148222419 536 THEDIFMKYATQGGKMNARDLQKFLNDVIskgf--aphGGIRFSIeASRSMLASMDFTCNGKLECDFFKRLWRYLDYFKA 613
gi 679012793 516 LVLCPMERLSENNPEINAVQLQRILNNITwrn---fqsFRLSFSLdACQGILALLDLNASGTLSIQEFRVLWKRLLFYLE 592
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2I7A_A        81 VFQKVQ-TSPGVLLSSDLWKAIENTDFlrgifisreLLHLVTLRYSDsVGRVSFPSLVCFLMRLEaMAKTFRNLSk-dGK 158
gi 512863605 583 IFSNLQsSKDRNLDKDQIGAALQSAGLitd----nfLVRLVQLRYADkDGSLSYSAFICCLLKIKaVTGMFEVADstgSG 658
gi 573878768 575 IFVHFDkNRSQSLDYPEIIPALQAAGLqvd----dfVLQLIGLRYTDpDLTISYPGFLHLLLKLDiMIGRFHSFHtlgNG 650
gi 47086161  580 IFITFDkNKNQALDYLEISPALSAAGIkvd----efILQLISLRYTEpDMTLSFPGFLFLLMKLDcMMRKFQSFDvtgTG 655
gi 637257930 509 IFIKEDeQNSGFLNASNLKRIIQERGLsvs----ekLLGLMTVRYGDaTMRMNYPGFVCCMIRLEtMEKVFHNLSk-dGR 583
gi 641753159 596 IFRRVEgTDSGFLDVSDLRNAVQRAGLavd----dqLLHVTALRYSDsSMRICFPDFVCCMIRLKtMASVFRSLSk--DG 669
gi 148227390 672 IFRSIDlNQTGFVDASGLRKAAQLTGLpis----naVINVMVLRYANsLEKLNFADFVCCIIRLEtVTKVFKNLSk-dGR 746
gi 513174287 628 LFRREDrNCSGFLDVYELKSAIQTAGLpvn----eqILHLMALRYGNvYKRMGFADFVSCMLRLEtMTYAFQNLAk-gGP 702
gi 148222419 614 IFTDADvDGSGFIGLEELSKAVKTAGIavs----sdQLTILLLRYGDyEMKLNFEDYLCCMVRLKsAFKRFQMLTs-dGK 688
gi 679012793 593 VFQKRDtSRSGKLDLVELRAAVQETGIsls----neVCNLMAIRYGDpDLKISFESFVCFMLRVEiMGEAFRNLTq-dGK 667
                        170
                 ....*....|....*.
Feature 1                        
2I7A_A       159 GLYLTEMEWMSLVMYN 174
gi 512863605 659 TVSLNYHQWLQLALYS 674
gi 573878768 651 TITLHYRQWLHSTMYN 666
gi 47086161  656 MISVNCRQFLHMTMYN 671
gi 637257930 584 EICFTEDEWVTMIMYC 599
gi 641753159 670 KICFTATEWMIFTMYC 685
gi 148227390 747 GVYLSGEEWMQIIMSS 762
gi 513174287 703 QVLMTVTEWLTLVMYI 718
gi 148222419 689 GVYLSHDKWLKIMMSC 704
gi 679012793 668 GIYLRESEWMMMTLYS 683

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