2I7A


Conserved Protein Domain Family
EFh_PEF_CAPN13_14

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cd16195: EFh_PEF_CAPN13_14 
Click on image for an interactive view with Cn3D
Penta-EF hand, calcium binding motifs, found in calpain-13 (CAPN13), calpain-14 (CAPN14), and similar proteins
CAPN13, also termed calcium-activated neutral proteinase 13 (CANP 13), a 63.6 kDa calpain large subunit that exhibits a restricted tissue distribution with low levels of expression detected only in human testis and lung. In calpain family, CAPN13 is most closely related to calpain-14 (CAPN14). CAPN14, also termed calcium-activated neutral proteinase 14 (CANP 14), is a 76.7 kDa calpain large subunit that is most highly expressed in the oesophagus. Its expression and calpain activity can be induced by IL-13. Both CAPN13 and CAPN14 contain a calpain cysteine protease (CysPc) domain, a C2-domain-like (C2L) domain, and a C-terminal Ca2+-binding penta-EF-hand (PEF) domain.
Statistics
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PSSM-Id: 320070
Aligned: 29 rows
Threshold Bit Score: 203.205
Created: 19-Feb-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca binding site [ion binding site]
Evidence:
  • Structure:2I7A; Homo sapiens calpain-13 binds a Ca2+ ion.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                               #   #      #             
2I7A_A         6 HHHHHSSGLVPRGSDIDATQLQGLLNQELlt-----gpPGDMFSLdECRSLVALMELKVNGRLDQEEFARLWKRLVHYQH 80  human
XP_002940402 507 QCHSRFLLFSDQDGRITNEGLHHLLTSLMkdf----dpLLPEITMeSCCRLIASLDTSAEGALCWEQFDRLWKNIITGSL 582 western clawed ...
XP_006627609 497 VARELFMKHAAAGGRCGAVELQGLLKEVIvtga--lagSREGFCLeRCKSFVALMDTRGLGRLEMEEFEALWEKFRKWTD 574 spotted gar
NP_998104    502 EARDLFVKHCAKGPYCRPLDLYNLLTEAIskgv--fagSEKMLSLeHCKSFVVLMDSQGMGRLDLTEFQALWDKLRKWTS 579 zebrafish
XP_008124129 429 SYKTIFLKYANQSSFLDASQLQRILNEVLlkdlmasqgSGNRFSFdSSKSLLALMDINANGRLSLDEFGELWRELNIYKD 508 green anole
XP_008173696 518 ASENIFLRYATQGSDLNASQLQRLLNEVFlkdr--lasPGGGFCFeSCRGILALMDLKSNGRLSLQEFKHLWKLLAQYKD 595 western painted...
NP_001079488 593 GYEKVFIRYCNKSSELYAEQLQKLLNEVLikdq-tfnaSRGDFTLdACRGILMLMDLNANGRLNLQEFERLWKRLSMCKD 671 African clawed ...
XP_004940238 550 SYKAIFLKYAKQGSAIDALQLQRLLNDMVlqde--mtsVGGEFSFdSCRAILALMDLNSNGQLTLQEFGSLWRSVTKYMD 627 chicken
NP_001087053 536 THEDIFMKYATQGGKMNARDLQKFLNDVIskgf--aphGGIRFSIeASRSMLASMDFTCNGKLECDFFKRLWRYLDYFKA 613 African clawed ...
KFW10700     516 LVLCPMERLSENNPEINAVQLQRILNNITwrn---fqsFRLSFSLdACQGILALLDLNASGTLSIQEFRVLWKRLLFYLE 592 sunbittern
Feature 1                                                                                        
2I7A_A        81 VFQKVQ-TSPGVLLSSDLWKAIENTDFlrgifisreLLHLVTLRYSDsVGRVSFPSLVCFLMRLEaMAKTFRNLSk-dGK 158 human
XP_002940402 583 IFSNLQsSKDRNLDKDQIGAALQSAGLitd----nfLVRLVQLRYADkDGSLSYSAFICCLLKIKaVTGMFEVADstgSG 658 western clawed ...
XP_006627609 575 IFVHFDkNRSQSLDYPEIIPALQAAGLqvd----dfVLQLIGLRYTDpDLTISYPGFLHLLLKLDiMIGRFHSFHtlgNG 650 spotted gar
NP_998104    580 IFITFDkNKNQALDYLEISPALSAAGIkvd----efILQLISLRYTEpDMTLSFPGFLFLLMKLDcMMRKFQSFDvtgTG 655 zebrafish
XP_008124129 509 IFIKEDeQNSGFLNASNLKRIIQERGLsvs----ekLLGLMTVRYGDaTMRMNYPGFVCCMIRLEtMEKVFHNLSk-dGR 583 green anole
XP_008173696 596 IFRRVEgTDSGFLDVSDLRNAVQRAGLavd----dqLLHVTALRYSDsSMRICFPDFVCCMIRLKtMASVFRSLSk--DG 669 western painted...
NP_001079488 672 IFRSIDlNQTGFVDASGLRKAAQLTGLpis----naVINVMVLRYANsLEKLNFADFVCCIIRLEtVTKVFKNLSk-dGR 746 African clawed ...
XP_004940238 628 LFRREDrNCSGFLDVYELKSAIQTAGLpvn----eqILHLMALRYGNvYKRMGFADFVSCMLRLEtMTYAFQNLAk-gGP 702 chicken
NP_001087053 614 IFTDADvDGSGFIGLEELSKAVKTAGIavs----sdQLTILLLRYGDyEMKLNFEDYLCCMVRLKsAFKRFQMLTs-dGK 688 African clawed ...
KFW10700     593 VFQKRDtSRSGKLDLVELRAAVQETGIsls----neVCNLMAIRYGDpDLKISFESFVCFMLRVEiMGEAFRNLTq-dGK 667 sunbittern
Feature 1                        
2I7A_A       159 GLYLTEMEWMSLVMYN 174 human
XP_002940402 659 TVSLNYHQWLQLALYS 674 western clawed frog
XP_006627609 651 TITLHYRQWLHSTMYN 666 spotted gar
NP_998104    656 MISVNCRQFLHMTMYN 671 zebrafish
XP_008124129 584 EICFTEDEWVTMIMYC 599 green anole
XP_008173696 670 KICFTATEWMIFTMYC 685 western painted turtle
NP_001079488 747 GVYLSGEEWMQIIMSS 762 African clawed frog
XP_004940238 703 QVLMTVTEWLTLVMYI 718 chicken
NP_001087053 689 GVYLSHDKWLKIMMSC 704 African clawed frog
KFW10700     668 GIYLRESEWMMMTLYS 683 sunbittern

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