Conserved Protein Domain Family
EFh_PI-PLCgamma1

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cd16214: EFh_PI-PLCgamma1 
EF-hand motif found in phosphoinositide phospholipase C gamma 1 (PI-PLC-gamma1)
PI-PLC-gamma1, also termed 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, or PLC-148, or phospholipase C-II (PLC-II), or phospholipase C-gamma-1 (PLC-gamma-1), is abundantly expressed in embryonal cortical structures, neurons, oligodendrocytes and astrocytes, and is involved in various cellular events, including proliferation, differentiation, migration, survival, and cell death. It also associates with many diseases, including epilepsy, Huntington's disease (HD), depression, Alzheimer's disease (AD) and bipolar disorder. PI-PLC-gamma1 plays a critical role in cell migration and tumor cell invasiveness and metastasis. It can mediate the cell motility effects of growth factors, including platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin-like growth factor (IGF) and hepatocyte growth factor (HGF), as well as adhesion receptors. Moreover, PI-PLC-gamma1 can modulate neurite outgrowth, neuronal cell migration and synaptic plasticity through the Trk receptor. PI-PLC-gamma1 contains an N-terminal pleckstrin homology (PH) domain, an array of EF hands, a PLC catalytic core domain, and a C2 domain. The PLC catalytic core domain is a TIM barrel with two highly conserved regions (X and Y) split by a highly degenerate linker sequence. Besides, PI-PLC-gamma1 has a second PH domain, two SH2 (Src homology 2) regions, and one SH3 (Src homology 3) region, which are present within this linker. PI-PLC-gamma1 is activated by receptor and non-receptor tyrosine kinases via its two SH2 and a single SH3 domain.
Statistics
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PSSM-Id: 320044
View PSSM: cd16214
Aligned: 6 rows
Threshold Bit Score: 296.737
Threshold Setting Gi: 148227087
Created: 18-Nov-2014
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Feature 1:EF-hand motif [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##############################                                                  
gi 130225     156 WLRKQFYSVDRNREDRISAKDLKNMLSQVNyrvpnmrFLRERLTDLEQRSGDITYGQFAQLYRSLMysaqKTMDLPFLEa 235
gi 190336957  156 WLRKQFYAVDRNREDRISCKDLKCMLCQVNyrvpnmkFLREKLPDGELRNGDVSYSHFAQLYRSLMfdaqKSMEIPLLQr 235
gi 676768633  144 WLRKQFYSLDRNREDRISAKDLKNMLSQVNyrvpnmrFLRERLTDVEQRNGDITYGQFAQLYRSLMfsaqKMMDVPFLEr 223
gi 148227087  154 WLRKQFYTLDRNREDKISVKDLKNMLSQVNyrvpnmrFLRDRLTELEQRSREINYAQFAMLYRSLMydaqKTIPIPFTEt 233
gi 556947614  156 WLRKQFYSVDRNREEKISSKDLKNMLSQVNyrvpnmkFLREKFADVDLRNGDITYGQYAQLYRSLMfdgqKTMEVPFLLr 235
gi 632973916  158 WLRKQFYIVDRNREDRITVKDLKNMLSQVNyrvpnmkFLREKFTDLELRSGDVTYCQFAQLYRSLMfdaqKHIEVPFLQr 237
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1                                                                                
gi 130225     236 stlraGERPELCRVSLPEFQQFLLDYQgelwavdrlQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKE 306
gi 190336957  236 -----FIDRPEQKISLEDFQNFLIEQQkelwaadsnKVQEYMFRYLKDPLREIEQPYFHQDEFLTYLFSKE 301
gi 676768633  224 ----gAERSEHFRVSLLEFQKFLLEYQrelwaadtlQVQEFMFNFLRDPLREIDEPYFSLDEFLTFLFSKE 290
gi 148227087  234 -----FGERERTKISLEDFQKFLLDYQkdmwatdlhKVREFMFHFLHDPLREIEEPYFTLEEFVTFLFSKE 299
gi 556947614  236 -----AVERPDPRVSLQEFQSFLVDSQkelwatntnQVQEFMFNFLRDPLREIEEPYFSLDEFLTFLFSKE 301
gi 632973916  238 ----nCEKPEVCKICLPDFQRFLLDYQkerwaidihQVKEFMFNYLRDPLREIEDPFFYLDEFLSFLFSKE 304

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