Conserved Protein Domain Family
EFh_PI-PLCgamma1_like

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cd16216: EFh_PI-PLCgamma1_like 
EF-hand motif found in 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like proteins
This family corresponds to a small group of uncharacterized 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like (PI-PLC-gamma1-like) proteins. Although their biological function remains unclear, they shows high sequence similarity with other phosphoinositide phospholipase C gamma proteins. They contain a core set of domains, including an N-terminal pleckstrin homology (PH) domain, four atypical EF-hand motifs, a PLC catalytic core, and a single C2 domain. The PLC catalytic core domain is a TIM barrel with two highly conserved regions (X and Y) split by a highly degenerate linker sequence. A second PH domain, which is split by two SH2 (Src homology 2) domains, and one SH3 (Src homology 3) domain, are present within this linker.
Statistics
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PSSM-Id: 320046
View PSSM: cd16216
Aligned: 4 rows
Threshold Bit Score: 318.414
Threshold Setting Gi: 542177482
Created: 12-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
Feature 1:EF-hand motif [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##############################                                                  
gi 512883424   82 WLGKQFNAVDRAREGSVTVKDLKALLPQVNyrvpnmrFLRDKMLEIEARSELTFPHFVLFYNNLMfdaqkSIIEQLELSF 161
gi 700398485  156 WLRKQFDGMDRSREGSITVKDLKAMLPQVNyrvpnmrFLRDKLVEVEARNEMTFSHFIQFYKNLMfdaqkSVIEQLELSF 235
gi 727037284  156 WLRKQFDGMDRAREGSITVKDLKAMLPQVNyrvpnmrFLRDKLVEVEARNEMTFSHFIQFYKNLMfdaqkSVIEQLELSF 235
gi 542177482  173 WLRKQFEVMDRSHEGSITVKDVKALLPQVNyrvpnmrFLKDKLQEVEARSDLSYPNFAQLYRTLMfdaqrSITEQLELSF 252
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                               
gi 512883424  162 PLRNVDRPSLCQISLYDFQRFLQFDQkeawagdinKVRGYLCNYLkdSDGDVCEPILQLDEFLTYLFSKE 231
gi 700398485  236 PLRNVDRPELCQVSLYDFQKFLLHDQkepwasdvgVVRDYMCTYLkeGSNEAVDPSFQLDEFLTYLFSKE 305
gi 727037284  236 PLRNVDRPELCQVSLYDFQKFLLHDQkeswasdvgLVRDYMCSYLkeSSNEASDPSFQLDEFLTYLFSKE 305
gi 542177482  253 PLRNVDRPELCQISLYDFQKFLQMDQkeswasdlgRVREFLMGYM--RGAPQPEPMLQLDEFLTFLYSKE 320

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