Conserved Protein Domain Family
EFh_PI-PLCeta1

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cd16220: EFh_PI-PLCeta1 
EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
PI-PLC-eta1, also termed 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1, or phospholipase C-eta-1 (PLC-eta-1), or phospholipase C-like protein 3 (PLC-L3), is a neuron-specific PI-PLC that is most abundant in the brain, particularly in the hippocampus, habenula, olfactory bulb, cerebellum, and throughout the cerebral cortex. It is also expressed in the zona incerta and in the spinal cord. PI-PLC-eta1 may perform a fundamental role in the brain. It may also act in synergy with other PLC subtypes. For instance, it is activated via intracellular Ca2+ mobilization and then plays a role in the amplification of GPCR (G-protein-coupled receptor)-mediated PLC-beta signals. In addition, its activity can be stimulated by ionomycin. PI-PLC-eta1 contains an N-terminal pleckstrin homology (PH) domain, four atypical EF-hand motifs, a PLC catalytic core domain, a C2 domain, and a unique C-terminal tail that terminates with a PDZ-binding motif, a potential interaction site for other signaling proteins. The PLC catalytic core domain is a TIM barrel with two highly conserved regions (X and Y) split by a highly degenerate linker sequence. The C-terminal tail harbors a number of proline-rich motifs which may interact with SH3 (Src homology 3) domain-containing proteins, as well as many serine/threonine residues, suggesting possible regulation of interactions by protein kinases/phosphatases.
Statistics
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PSSM-Id: 320050
View PSSM: cd16220
Aligned: 4 rows
Threshold Bit Score: 272.668
Threshold Setting Gi: 679194398
Created: 18-Nov-2014
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Feature 1:EF-hand motif [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##############################                                                  
gi 121947010  146 WVKQTFEEADKNGDGLLNIEEIHQLMHKLNvnlprrKVRQMFQEADTDENQGTLTFEEFCVFYKMMSlrrDLYLLLLSYS 225
gi 679194398  132 WVKQTFEEADKNGDGLLNIEEIHQLMHKLNvnlprrKVRQMFQEADTDENQGTLNFEEFSVFYKMMSlrrDLYLLLLSYS 211
gi 556949432  128 WIKQTFEEADKNGDGLLNIEEIYQLMHKLNvnlprrKVRQMFQEADTDENRGTLTLEEFCVFYKMMSlrrDLYLLLMCFS 207
gi 632934937  158 WMKQTFEEADKNGDGLLSIEEIYQLMHKLNvnlprrKIRQMFQEADTDDKQGTLNFEEFCVFYKMMSlrrDLFLLLKSYS 237
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1                                                                      
gi 121947010  226 DKKDHLTVEELAQFLKVEQkmnnvttdYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPA 286
gi 679194398  212 DKKDHLTAEELAQFLKVEQkmnnvtpeYCLDIIQKFEVSEENKKQNVLGIEGFTNFMRSPA 272
gi 556949432  208 DKKNHLSVEDLANFLRTEQkvnnvtteYCIDIIKQFEVSEENKEQNILGVEGFTNFMRSPA 268
gi 632934937  238 DKKDHLTLEEVAVFLNKEQkmanvtleYCMDIVEKFEVSEENKQQNVLGIEGFTDFMRSPA 298

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