Conserved Protein Domain Family
EFh_CREC_RCN2

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cd16224: EFh_CREC_RCN2 
EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2)
RCN2, also termed calcium-binding protein ERC-55, or E6-binding protein (E6BP), or TCBP-49, is an endoplasmic reticulum resident low-affinity Ca2+-binding protein that has been implicated in immunity, redox homeostasis, cell cycle regulation and coagulation. It is associated with tumorigenesis, in particular with transformation of cells of the cervix induced by human papillomavirus (HPV), through binding to human papillomavirus (HPV) E6 oncogenic protein. It specifically interacts with vitamin D receptor among nuclear receptors. RCN2 contains an N-terminal signal sequence followed by six copies of the EF-hand Ca2+-binding motif, and a C-terminal His-Asp-Glu-Leu (HDEL) tetrapeptide that is required for retention of RCN2 in the endoplasmic reticulum (ER).
Statistics
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PSSM-Id: 320022
View PSSM: cd16224
Aligned: 8 rows
Threshold Bit Score: 426.079
Threshold Setting Gi: 71834660
Created: 24-Nov-2014
Updated: 18-Aug-2016
Structure
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Aligned Rows:
  next features
Feature 1:EF-hand motif [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ####################          ##########                                        
gi 2493460    29 HYPLGERRSDYDREALLGVQe---------DVDEYVKLGHeeqqkRLQAIIKKIDLDSDGFLTESELSSWIQMSFkhyam 99
gi 597501019  18 GTSLGEHRPDYDKEALLGGQd---------EVEEFSKLSPeeqqkRLKVIISRIDVDLDGFLTEAELSSWIQHSFksyii 88
gi 148233842  25 HYENGEHNAEYDKKLFLGGEe---------EAEEFTELSSedqlkRLKLIIRRIDTDSDGYLTEEELSSWIQKSFrhyil 95
gi 632938796  31 HYVNGEHNADYDREVLFGGEk---------EAGEFAKLSPeeqqsRLKSLIKKMDLNSDGFLSHGELSTWIQNSFrhyat 101
gi 573881814  22 ASTFNAEDPEYDGSIFFRNE----------DQDEIEKLSPeeqkrRLAVIVKKIDTDLDGFLTEGEISLWIQQVYrryav 91
gi 71834660   39 EDHVFKHNHEHNANTFLGSE----------DKDEIQKLSPseqrkRLVEIVKKIDTNSDKYLTPEEITVWIQRVYrkyal 108
gi 149041736 102 HYPQGEHRADYDRETLLGVQe---------DVDEYVKLGHeeqqrRLQSIIKKIDSDSDGFLTENELSQWIQMSFkhyam 172
gi 556976552  30 HFMDAEHNLEYDKEAFFGGEvieesntleiDADELAKLSPeeqqeRLKSLIKKMDINSDGLLSEDELSLWIQQSFhyyat 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 2493460   100 qEAKQQFVEYDKNSDDTVTWDEYNIQMYDRVidfdentalddaeeesfrklhlKDKKRFEKANQDSGPGLSLEEFIAFEH 179
gi 597501019  89 eDAKQQFQHYDKDGDGRVSWEEYNIQMYDRVidfeedttlddaeeesfrqlhlKDKKRFQKANKDGDSHLDFEEFAAFEH 168
gi 148233842  96 eDTKEHFADIDKDGDGIVTWDEYNMHLYDRIidydentvledeeeesfrlihmKDKRRFDHADTDKIPGLNLTEFTDFEH 175
gi 632938796 102 qDSKDQFPEYDVDGNGMITWEEYNIHAYDHVmdydeniplddeeeesmrqlfwKDKKRFEKANLDGLPGLSPTEFIAFEH 181
gi 573881814  92 eDVAEKFLEFDKDGDGAVSWNEYTLLVHDRIidmdedkvpenseekslhflhlKEKQRFDHANTDGKPGLNVTEVLAFLH 171
gi 71834660  109 dDAEERFPEFDSNNDGLVSWDEYNMVMHGHTvevdadavledpeeeslrflhaKEKRRFDFANMDGSAGLNLTEFLAFTH 188
gi 149041736 173 qEAKQQFVEYDKNSDGTVTWDEYNVQMYDRVidfdentalddteeesfrqlhlKDKKRFEKANQDSGPGLNLEEFIAFEH 252
gi 556976552 110 iETKQDFPKVDTDGNGAITWEEYNMYAYNTVihydedtvtndneeesfktlhlREKKRFKAADLDGVPGLNISEFVAFQH 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 2493460   180 PEEvdymtefVIQEALEEHDKNGDGFVSLEEFLGDYRWDPtanedpewilvEKDRFVNDYDKDNDGRLDPQELLPWVVPN 259
gi 597501019 169 PEEadymkefVIQESLEEHDKDGDGFVSLQEFLGDYRRDPaakedpewivvEEDRFKNDYDKDKDGKLSPKELLTWVMPN 248
gi 148233842 176 PEEtdhmsefVIEGALEEHDEDGDGFVSLEEYLGDYTQDSgavedphwlivEKDRFVNDYDKDGDGRLNPTELLSWIVPN 255
gi 632938796 182 PEEvdymmdyVIQDALDEHDQDKDGFISLEEFLGDYKKDPnvqddpewvsvERDRFENDYDKNTDGKLDPQELQAWVVPN 261
gi 573881814 172 PSEvdhmskyAIEDVLNEYDRDNDGFISLHEFLGDLRSPDgvnqs-qweieEKLRFVNLYDRDNDGKLNYEEQLLWVAPN 250
gi 71834660  189 PSEvdhmtdfAIEDVLSEYDLDKDGFISLSEFIGDLRTNEqdeps-qweieETVRFKDLYDQDQDGKLNRDEQLRWVAPN 267
gi 149041736 253 PEEvdymtefVIQEALEEHDKNGDGFVSLEEFLGDYRRDPtanedpewilvEKDRFVNDYDKDSDGRLDPQELLSWVVPN 332
gi 556976552 190 PEEvsymlnyVVKETLDEVDKDQDGFISLSEFLGDYKKDPtsadp-ewlivEKDHFEKDYDTNADGKLDPQELIPWVMPN 268
                        250       260       270
                 ....*....|....*....|....*....|....*..
Feature 1                                             
gi 2493460   260 NqgiaqeEALHLIDEMDLNGDKKLSEEEILENPDLFL 296
gi 597501019 249 NeglaqeEAVHLLDEMDLDGDRRLSANEILENQDLFL 285
gi 148233842 256 NlgisqeEAIHLMTEMDKNEDQRLSEEEILQNKDIFL 292
gi 632938796 262 NlevageEAEHIIKEIDTNGDGKLTEAEILNSQDLFL 298
gi 573881814 251 SygtareEALHLIQEMDRNGDGRLSEMEIMSNMQTFM 287
gi 71834660  268 SygsareEALHLIKEMDQDGDNRLSETEILKNQDTFM 304
gi 149041736 333 NqgiaqeEALHLIDEMDLNSDKKLSEEEILENQDLFL 369
gi 556976552 269 NmdvaqkEASHLITSMDLNGDGKLSEAEILENQELFL 305

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