Conserved Protein Domain Family
EFh_CREC_cab45

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cd16225: EFh_CREC_cab45 
EF-hand, calcium binding motif, found in 45 kDa calcium-binding protein (Cab45)
Cab45, also termed stromal cell-derived factor 4 (SDF-4), is a soluble, lumenal Golgi resident low-affinity Ca2+-binding protein that contains six copies of the EF-hand Ca2+-binding motif. It is required for secretory pathway calcium ATPase1 (SPCA1)-dependent Ca2+ import into the trans-Golgi network (TGN) and plays an essential role in Ca2+-dependent secretory cargo sorting at the TGN.
Statistics
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PSSM-Id: 320023
View PSSM: cd16225
Aligned: 19 rows
Threshold Bit Score: 269.169
Threshold Setting Gi: 17532575
Created: 24-Nov-2014
Updated: 18-Aug-2016
Structure
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Aligned Rows:
  next features
Feature 1:EF-hand motif [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ####################   ########                                                 
gi 21263447   67 LEMDGHLNRGFHQEVFLGKDl--GGFDEDAEprr-srrKLMVIFSKVDVNTDRKISAKEMQRWIMEKTaehfqeameESK 143
gi 443684707  28 MEQDGHLNRDYHKEVIIGNH---EEFEEGDEeek--ekKLREIFFKVDTDLDTYISQEELEEWIQVKVqehfdestdETE 102
gi 405951048  53 FEKDGHINKDFHKEVFLGNH---EEIDDEPIqia--eaKLVDIFHKIDKDTDGYLNEGELDSWILDKInehmneameENA 127
gi 676442316  38 MEHDGHINKEYHKELFLGDH---EEIESDSKsa---daKMKDIFKKVDLDTDGSLSELEMEDWIKQKMqehfdeaitENE 111
gi 780071727  73 MERNGALNKDFQQELFWGPAh--EEMTDVREeeg--rlRLMEIFKLADRDEDKFLTMDELAAWIEEKTaehyseavsSSR 148
gi 699237245  92 FGRDGNLNSNYHKEVFLGEEv--KKFENGEYelkeqknQLIKMFKLIDENGDGSLDEAELSKWVLHKTkehfseakqENE 169
gi 156386383  18 LERDGDINKDFHHEAFLGKLi--KDGTLTFEnkm-gykKLIEIFHQVDYDKDHLVSKDELSYWIHERIlehveearlRNE 94
gi 646697540  66 LERDGDVNINFHKDVIIGDV---KEGPQYEDpk----tLLENIFKNADVSGDGLLSLQELSDWINKKIqehinealrDNF 138
gi 17532575   35 LEKDGELNDKFRQEMIFSHNldpSDSKQLSE-------SIKEMFKKTDVNDDGFLTAGELKQQIRKNMeehleksknDSE 107
gi 675378036  74 MERDGHLNKEFRKEVLLGNEs--QSGTQDEQ-------LLISIHKKADTNQDGFLNVEELEIWIMNKVkehfqravrDNF 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 21263447  144 THFRAV-DPDGDGHVSWDEYKVKFLASKghsekevadairln-eelkvdeetqevleNLKDRWYQADsPPADLLLTEEEF 221
gi 443684707 103 RIFKHL-DSDKDGTVAWEEFHVHFLLAKgvsaeeaekqvsdyyavgsldpdakenliRYKFRWAEADlDPQDNKLTMEEF 181
gi 405951048 128 AIFKHL-DPDGDGYVEWKEYYKHFLLAKghglnetekyledy-dtdilqdderdklvWYKFKWTDADiKPIDNRLDVEEF 205
gi 676442316 112 QIFKHL-DPDGNGKVHWKEYYVHFLLAMdvpeekarkhvidy-diveldsddkedliRYKFRWADADeEPEDNELTKEEF 189
gi 780071727 149 QGFPQV-DTNKDGYLQWDEYREQFFKHRgldeeklkayreg---klsidetleqdyaMYRDRWDRAD-EDNDNSLSVEEF 223
gi 699237245 170 QKFKEL-DTDNDGNVTWNEYLTEFLSRKnysrvevaeklrnk-vkievdakvrdevdDVHDKWLQAS-NDGDSNMSVSEF 246
gi 156386383  95 GLFKSA-DLNKDGSITWLEYRTKLLVGDgnatvspkkyv--------fssgedgglpDEYGHWKKAD-VNQDGKIDVTEF 164
gi 646697540 139 GLFDAIdNNPKNGVISWEEYHTYFLRQKgfskeyaenhdkk---hrglnrsikeavmRDRASWSEAA-HSDPDHLTLDEF 214
gi 17532575  108 IFFDIV-DTNKDGSIVWEEFEPHFSKMHekdhsdselmd--------vhtedphrvdDEKRMFNRSD-ITRDGRLDRMEW 177
gi 675378036 145 LIFTSL-DKDHNGRVSWEEFHVNFMIEQgfnktyaknhpen---hkhlkrkvkekilLDKAAWSEAA-NSDPDALNIDEF 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 21263447  222 LSFLHPEHsrgmlrfMVKEIVRDLDQDGDKQLSVPEFISLPVGTVenqqgqdi--ddnwvkdRKKEFEELiDSNHDGIVT 299
gi 443684707 182 ASFRHPEQskdmlerLVKEIMDNLDQDSNDEISLKEFVALPPGEIeyaaqds---dkmwqneREKEFKEVvDLNSDGKIT 258
gi 405951048 206 FSFRHPEHsvqlienMVLSIINSLDVDKDGKLTLKEFSKPDIMEEdptteke---reeeykvREKEFVSAiDKNKDGVAT 282
gi 676442316 190 LSFRHPEQspkslnnMVFSIINALDKNGDNILTVQEFAALPPGEVegedqkdl--drqwqkeRENEFHIAvDIDRDGKAT 267
gi 780071727 224 LAFLHPEHcksmlsmLVEEVLHDLNQNDDTALNLREFLSLPDDAHldlgkaan--ddewvreRKNEFEENiDLDGDGIAT 301
gi 699237245 247 LDFQHPETgremleyLVQDFLHDMDVDGDEVLTIQEYISVGSDVDvdtqdd------dwakeRRNEFRNViDQNKDGKVT 320
gi 156386383 165 LYFQHPEYnpetikkMAEDMLVNFDRNGDKIMTGDEFLALPPGEVdpdqaaa---ekeykedRKREFKLM-DKNGDGVVK 240
gi 646697540 215 LSFRHPESshatiiaLVDELLDKFDRDGDEILTEDEFSVLQTEGDgekeget---ltqgedeRRKEFRDViDRNHDGKAD 291
gi 17532575  178 HIFLHPEYsaqglveIVNDLMGVYDKNNDEVVSQDDFVNGIPGTVdelnpefenmeklekerRLREFNEEiDENSDGKAT 257
gi 675378036 220 LTFRHPEHshvsllnMVNDIIGSLDNDGDEMLSEQEFVEMPDPDEtnqsla------ewkqqRTREFRDTiDLNHDGRVS 293
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
Feature 1                                                        
gi 21263447  300 AEELESYMDPMNeynalnEAKQMIAVADENQNHHLEPEEVLKYSEFFT 347
gi 443684707 259 KDELKVYMDPKNpthsrsEAASLIQMADENNDGKLSLTEVLDNEDLFM 306
gi 405951048 283 KEEMMEYMNPRNpqqslqEAKNLMSLMDDNKDGKLSVDEIKKHKDIFI 330
gi 676442316 268 KEEVHKYIDPRNpiqakmEAKSLISLIDVNKDNKLSIGEIMDRKDIFL 315
gi 780071727 302 FEELEKYMDPRNkqhaesEARHLMGVADMDGDGKLSPREVSNSYFVFL 349
gi 699237245 321 KEELKRYLDPMSeamaqqEARQLIGFGDENFDMKLSLKELLENSEYYT 368
gi 156386383 241 LDELALYLDPRNeqhaanEASYLISVADKNKDAKLSELEMLQNYQLFT 288
gi 646697540 292 RKELLMYNDPKNprhaheEAVALLVLSDADHDGSLSLQEILNKMDLFL 339
gi 17532575  258 FRELYDYVDPQNfrlaskEVNDIMMLTDANNDEKLSLEELLERDWLLA 305
gi 675378036 294 REELLMYNDPENpvhskmEAKKLIKLADVNKDQLLSLEEVLAKKDSFL 341

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