Conserved Protein Domain Family
EFh_CREC_RCN2_like

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cd16227: EFh_CREC_RCN2_like 
EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2) mainly from protostomes
This family corresponds to a group of uncharacterized RCN2-like proteins, which are mainly found in protostomes. Although their biological function remains unclear, they show high sequence similarity with RCN2 (also known as E6BP or TCBP-49), which is an endoplasmic reticulum resident low-affinity Ca2+-binding protein that has been implicated in immunity, redox homeostasis, cell cycle regulation and coagulation. Members in this family contain six copies of the EF-hand Ca2+-binding motif, but may lack a C-terminal His-Asp-Glu-Leu (HDEL) tetrapeptide that is required for retention of RCN2 in the endoplasmic reticulum (ER).
Statistics
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PSSM-Id: 320025
Aligned: 13 rows
Threshold Bit Score: 309.247
Created: 30-Apr-2015
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
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Feature 1:EF-hand motif [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ##################### #########                                                 
KDR14829      66 HIVNGHHHSEFDHESILGSVKeAEEFDHLNPveakrRLRILLTKMDFDKDENIDRKELHAWILRSFkmlseeESQERFED 145 Zootermopsis ne...
KFM58050      45 HFKDGEHDYEFDHESVLGSRQaAEEFHNLSPseakaRLKLLAHKMDENEDSFVDRKELANWILRSYamlteeEAMQEMEN 124 Stegodyphus mim...
XP_009167849  53 FNAFGQRDFDLDHEVVLGSFEqTQYFKQLEPeeaktRLGQLFEKMDANQNGNLDKNELIDWIVQSFtnldleSAKIKLND 132 Opisthorchis vi...
EZA61006      73 HYAEGEHHQEFDHEAILGSVKeAEEFDKLPIeeskkRLGILLTKMDLNNDKYIERNELKAWILRSFsmlsaeESKDRFDD 152 Cerapachys biroi
XP_009043912  33 HTKDGEHNPHYDHEAVIGSKQlEHEFDELPPaeaiqRLENLVKHHDLNADNIITHDELKKWILASYmsldeeESDEKFQE 112 owl limpet
XP_005107699  39 HAKGGIHNPVFDQEALLGSHD-LEELAELDEdvrtqRLKNLAKSHDANDNDIIELDELKEWILQSFrlldheEAMERWNN 117 California sea ...
KFB45689      44 HMEGEEHFSEFDHEAILGSVKeAEEFDNLSPeeskkRLAVLVTKMDQNSDGFVDRHELKAWILRSFkslaeeEASERFDD 123 Anopheles sinensis
CDJ97399      29 RHQGGEDDHHLDHQAVLGSRKtASEFDEIPKeeskrRLEVLAKGMDVNEDGFVDETELTNWVERSMvaldneEVIDRMGE 108 barber pole worm
NP_001260075  58 HGEDGEHNVEFDHEAIIGNTKeAQEFDSLSPdeskrRLLILIKMMDLNKDEFIDRHELKAWILRKLse---eEAADRFEE 134 fruit fly
CEF65043      40 KLKDPKHSEHADHEAVLGSKKeAQEFDELSEeeskkRLAVLAKRMDINSDGKVTVEELTEWIHKSMirldntEAEERFKE 119 Strongyloides r...
ERL83817      57 HMNSDEHRTNFDHEAILGSAKiSEEFDALPPeqskeRLQALLNVMDTSRDKFIDRSELIQWIVHSFqmlsaeEANEKFDE 136 mountain pine b...
XP_970591     50 FTDSGEHHNEFDHEAIIGSHKeAEEYDHLPPdeakrRLRILLKKMDLNGDEQIDKKELKAWILRSFkmlseeEANERLED 129 red flour beetle
XP_001901161  45 SAESDQHNIHADHKVVIGSRKeAEIFDDLSPeeakrRLAVLAKKMDKDDDGYVIREELERVIKQNMisldleESNDRFRE 124 Brugia malayi
Feature 1                                                                                        
KDR14829     146 ADDNEDGVVTWSEYIADSYGINgsdednsisng-----dnseenkllsDDKVMFEAADKNKDGSLNKAEFLMFSHPEEhp 220 Zootermopsis ne...
KFM58050     125 EDGDGDGKVTWEEHIADVFGIMdddmigsvdk-------tsddfqmlrNDKELFEAADVNKDGILDKSEFPAFSHPEEfe 197 Stegodyphus mim...
XP_009167849 133 YDADQDGTLTWEEYTTRVYGYSsteleqlakdss---netqaflrsieEEKIKFKSADLDQNGHLNATEFTAFEHPHNyp 209 Opisthorchis vi...
EZA61006     153 ADTDQDGRVNWDEVLIDAYGNDpedfpp--------------eesmmeDEKETFEAADVNKDGYLDTEEFKAYTHPEEtp 218 Cerapachys biroi
XP_009043912 113 NDVDGNGNVSWRELVKKEFGYDlediedfkkntdkqepdtkefllmldEEEKRFMTADTDNNGNLEKQEFRAYYHPNEyp 192 owl limpet
XP_005107699 118 EDEDGDGKLTFSEILNKQFSVTeeelsemenade--eekdtdvlqlvaDDKKRFAAADLNQDGSLDENEFLAYFQPYDyp 195 California sea ...
KFB45689     124 VDLNNDESVTWEEYLQETYGMDsedeegmrlpfe--eprneeerkliqDDKEMFDAADSNKNGALDATEFVQFISPEEfp 201 Anopheles sinensis
CDJ97399     109 MDMNGDKLVSWDEYMADSFPDQdvknlda------------ddrklmeEDKLYFKAADLDGDGKLNQDELSAFLNPENyk 176 barber pole worm
NP_001260075 135 IDQDADERITWKEYLQDTYAMEdedfkketidy----dsyedeqkmikQDKEMFNAADTNKDGVLTLEEFVLFQNPEEhp 210 fruit fly
CEF65043     120 IDANKDNFITWQEYAHEAFGTEtsangeaiv--------dpddkklfeEDKNYFNAADVNKDGKITLTEFYAFQAPEHhk 191 Strongyloides r...
ERL83817     137 TDENDDKHISWNEYILESYGSEelslqsnwad------sdeniriefeQDQELFRAVDANNDGLLNRQEFSKFTNPEEhq 210 mountain pine b...
XP_970591    130 ADEDNNGIVTWQEYLSDAYGVDkednlsvg----------deneqlikDDKEMWAAADTNNDGVLDSKEWIAFSHPEEhp 199 red flour beetle
XP_001901161 125 MDTNQDNLVTWDEYVQESFGDIdpeneimd----------addkrlleDDRKFFSTADQDKDDKLSNAEFHAFQNPESfp 194 Brugia malayi
Feature 1                                                                                        
KDR14829     221 dmlpvILKQTLQEKDIDGDGFISFQEFISDRGKHQekew---lvvEKEKFDNEfDKDKDGKLNGAEILSWVVPSNdeiad 297 Zootermopsis ne...
KFM58050     198 rmyqvVYEQAMRKRDADKDGFLSFEEYVADTYGATpvstteqyimEKDRFTHDyDLNNDNKLDKEEVLLMLIPNNieaae 277 Stegodyphus mim...
XP_009167849 210 hmapyEIIHTLRDFDTDNDGFISQQEYLADDKMHReaf-----kiELENFKRY-DTNGDGRLDQEEMKHWVTPGFqrtat 283 Opisthorchis vi...
EZA61006     219 rmfplLVNQSLKDKDKDKDGYISFQEFIGDRAASKdkkw---llsEKDKFDFDhDKNADGRLDSEEILSWLVPSNediad 295 Cerapachys biroi
XP_009043912 193 hmhgvEIERALRTHDKNKDNQVSKAEFIGGLLFLEdrev---yltEEENFNSF-DLDGNGKLSQDEVRAWVIQDNnqaae 268 owl limpet
XP_005107699 196 hmfevEIERTMKEMDKDGDGSVSMEEFIGDEVDEEsr------lvEVTNFEDL-DKDKDGKLSREEVRPWALPDNnevav 268 California sea ...
KFB45689     202 qmlptILKQTLRDKDKNNDGRIDFQEFVGDNAMDHdkew---lvvEMDKFKEDfDRDGDGYLNGNEILSWVVPSNdevat 278 Anopheles sinensis
CDJ97399     177 hmhkvLVEVTMKEKDANKDGAIDLKEFLGEMADNEhsdw---htvEKDRFLAEyDSDGDGVLRGDEVRRWLIPDVkavak 253 barber pole worm
NP_001260075 211 qmlpiLLEHTMQDKDADHDGKINFQEFVGDAASHHdkew---litEKERFDKDhDSNGDGVLTGDEVLSWIVPSNtaian 287 fruit fly
CEF65043     192 hmhgvLIQHTLIDKDKNNDGKISFEEYMHETQGSSdsew---yqvEKDRFEKEyDKNKDGLLDEEEIKKWLIPDLketak 268 Strongyloides r...
ERL83817     211 dlsalLLKQILRSKDTDNDDALNFKEFLSEKGSQMskea---lisQKDEFDEY-DMNKDGKLTGDEIIYWMFPQNekiae 286 mountain pine b...
XP_970591    200 smlpiILEQTLRDKDKDGDKSISFQEFVGDRAHEHdkew---lqvEKDKFDHDlDKDGDGKLTSNEILSWIVPSNeeiae 276 red flour beetle
XP_001901161 195 hmhaaLIEVTMKEKDKNHDGKITLDEFLDDLAGDQksdw---ymvEKNRFEYDyDKDRNGVLEGAEIASWLVMNLettaa 271 Brugia malayi
Feature 1                                        
KDR14829     298 eEVSHLFAASDDDHDELLTFDEILDHHEIFVG 329 Zootermopsis nevadensis
KFM58050     278 tEADHLIGSSDSNKDGRLSVDEIVDHHEIFVG 309 Stegodyphus mimosarum
XP_009167849 284 eEAEHLFSETDANGDKELSKEEVLAQHELWVG 315 Opisthorchis viverrini
EZA61006     296 dEVDHLFAGSDDDHDNRLSFDEILDHHDIFVG 327 Cerapachys biroi
XP_009043912 269 dEVLHLISQADDNKNNELTLAEILEHYDDFVG 300 owl limpet
XP_005107699 269 eEAEHLLESCDEDGDKQLTIDEIVSKEEEFLA 300 California sea hare
KFB45689     279 dEVDHLFAASDDDHDDRLSHQEIIEKYDIFVG 310 Anopheles sinensis
CDJ97399     254 qEATHLINGADKDKDGKLSIAEIVDAYELFVG 285 barber pole worm
NP_001260075 288 dEVDHLFVSTDEDHDDRLSYLEILNNYDTFVG 319 fruit fly
CEF65043     269 tEADHLMDKADMDKNLELTYSEIVGAHQTFVG 300 Strongyloides ratti
ERL83817     287 eETTHLFAQCDDNHDDLLSFDEILDHHEIFVG 318 mountain pine beetle
XP_970591    277 eEVDHLFASSDDDHNDVLSFDEVVEHHETFVG 308 red flour beetle
XP_001901161 272 eEVEHLMSKADKDNDGRLSIDEIISESDLFVG 303 Brugia malayi

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