Conserved Protein Domain Family
EFh_CREC_RCN2_like

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cd16227: EFh_CREC_RCN2_like 
EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2) mainly from protostomes
This family corresponds to a group of uncharacterized RCN2-like proteins, which are mainly found in protostomes. Although their biological function remains unclear, they show high sequence similarity with RCN2 (also known as E6BP or TCBP-49), which is an endoplasmic reticulum resident low-affinity Ca2+-binding protein that has been implicated in immunity, redox homeostasis, cell cycle regulation and coagulation. Members in this family contain six copies of the EF-hand Ca2+-binding motif, but may lack a C-terminal His-Asp-Glu-Leu (HDEL) tetrapeptide that is required for retention of RCN2 in the endoplasmic reticulum (ER).
Statistics
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PSSM-Id: 320025
View PSSM: cd16227
Aligned: 13 rows
Threshold Bit Score: 309.247
Threshold Setting Gi: 524902959
Created: 30-Apr-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
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Feature 1:EF-hand motif [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##################### #########                                                 
gi 646708580  66 HIVNGHHHSEFDHESILGSVKeAEEFDHLNPveakrRLRILLTKMDFDKDENIDRKELHAWILRSFkmlseeESQERFED 145
gi 675365148  45 HFKDGEHDYEFDHESVLGSRQaAEEFHNLSPseakaRLKLLAHKMDENEDSFVDRKELANWILRSYamlteeEAMQEMEN 124
gi 684384432  53 FNAFGQRDFDLDHEVVLGSFEqTQYFKQLEPeeaktRLGQLFEKMDANQNGNLDKNELIDWIVQSFtnldleSAKIKLND 132
gi 607366850  73 HYAEGEHHQEFDHEAILGSVKeAEEFDKLPIeeskkRLGILLTKMDLNNDKYIERNELKAWILRSFsmlsaeESKDRFDD 152
gi 676422156  33 HTKDGEHNPHYDHEAVIGSKQlEHEFDELPPaeaiqRLENLVKHHDLNADNIITHDELKKWILASYmsldeeESDEKFQE 112
gi 524902959  39 HAKGGIHNPVFDQEALLGSHD-LEELAELDEdvrtqRLKNLAKSHDANDNDIIELDELKEWILQSFrlldheEAMERWNN 117
gi 668457686  44 HMEGEEHFSEFDHEAILGSVKeAEEFDNLSPeeskkRLAVLVTKMDQNSDGFVDRHELKAWILRSFkslaeeEASERFDD 123
gi 560117982  29 RHQGGEDDHHLDHQAVLGSRKtASEFDEIPKeeskrRLEVLAKGMDVNEDGFVDETELTNWVERSMvaldneEVIDRMGE 108
gi 442626081  58 HGEDGEHNVEFDHEAIIGNTKeAQEFDSLSPdeskrRLLILIKMMDLNKDEFIDRHELKAWILRKLse---eEAADRFEE 134
gi 685830121  40 KLKDPKHSEHADHEAVLGSKKeAQEFDELSEeeskkRLAVLAKRMDINSDGKVTVEELTEWIHKSMirldntEAEERFKE 119
gi 546671555  57 HMNSDEHRTNFDHEAILGSAKiSEEFDALPPeqskeRLQALLNVMDTSRDKFIDRSELIQWIVHSFqmlsaeEANEKFDE 136
gi 91082161   50 FTDSGEHHNEFDHEAIIGSHKeAEEYDHLPPdeakrRLRILLKKMDLNGDEQIDKKELKAWILRSFkmlseeEANERLED 129
gi 170592817  45 SAESDQHNIHADHKVVIGSRKeAEIFDDLSPeeakrRLAVLAKKMDKDDDGYVIREELERVIKQNMisldleESNDRFRE 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 646708580 146 ADDNEDGVVTWSEYIADSYGINgsdednsisng-----dnseenkllsDDKVMFEAADKNKDGSLNKAEFLMFSHPEEhp 220
gi 675365148 125 EDGDGDGKVTWEEHIADVFGIMdddmigsvdk-------tsddfqmlrNDKELFEAADVNKDGILDKSEFPAFSHPEEfe 197
gi 684384432 133 YDADQDGTLTWEEYTTRVYGYSsteleqlakdss---netqaflrsieEEKIKFKSADLDQNGHLNATEFTAFEHPHNyp 209
gi 607366850 153 ADTDQDGRVNWDEVLIDAYGNDpedfpp--------------eesmmeDEKETFEAADVNKDGYLDTEEFKAYTHPEEtp 218
gi 676422156 113 NDVDGNGNVSWRELVKKEFGYDlediedfkkntdkqepdtkefllmldEEEKRFMTADTDNNGNLEKQEFRAYYHPNEyp 192
gi 524902959 118 EDEDGDGKLTFSEILNKQFSVTeeelsemenade--eekdtdvlqlvaDDKKRFAAADLNQDGSLDENEFLAYFQPYDyp 195
gi 668457686 124 VDLNNDESVTWEEYLQETYGMDsedeegmrlpfe--eprneeerkliqDDKEMFDAADSNKNGALDATEFVQFISPEEfp 201
gi 560117982 109 MDMNGDKLVSWDEYMADSFPDQdvknlda------------ddrklmeEDKLYFKAADLDGDGKLNQDELSAFLNPENyk 176
gi 442626081 135 IDQDADERITWKEYLQDTYAMEdedfkketidy----dsyedeqkmikQDKEMFNAADTNKDGVLTLEEFVLFQNPEEhp 210
gi 685830121 120 IDANKDNFITWQEYAHEAFGTEtsangeaiv--------dpddkklfeEDKNYFNAADVNKDGKITLTEFYAFQAPEHhk 191
gi 546671555 137 TDENDDKHISWNEYILESYGSEelslqsnwad------sdeniriefeQDQELFRAVDANNDGLLNRQEFSKFTNPEEhq 210
gi 91082161  130 ADEDNNGIVTWQEYLSDAYGVDkednlsvg----------deneqlikDDKEMWAAADTNNDGVLDSKEWIAFSHPEEhp 199
gi 170592817 125 MDTNQDNLVTWDEYVQESFGDIdpeneimd----------addkrlleDDRKFFSTADQDKDDKLSNAEFHAFQNPESfp 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 646708580 221 dmlpvILKQTLQEKDIDGDGFISFQEFISDRGKHQekew---lvvEKEKFDNEfDKDKDGKLNGAEILSWVVPSNdeiad 297
gi 675365148 198 rmyqvVYEQAMRKRDADKDGFLSFEEYVADTYGATpvstteqyimEKDRFTHDyDLNNDNKLDKEEVLLMLIPNNieaae 277
gi 684384432 210 hmapyEIIHTLRDFDTDNDGFISQQEYLADDKMHReaf-----kiELENFKRY-DTNGDGRLDQEEMKHWVTPGFqrtat 283
gi 607366850 219 rmfplLVNQSLKDKDKDKDGYISFQEFIGDRAASKdkkw---llsEKDKFDFDhDKNADGRLDSEEILSWLVPSNediad 295
gi 676422156 193 hmhgvEIERALRTHDKNKDNQVSKAEFIGGLLFLEdrev---yltEEENFNSF-DLDGNGKLSQDEVRAWVIQDNnqaae 268
gi 524902959 196 hmfevEIERTMKEMDKDGDGSVSMEEFIGDEVDEEsr------lvEVTNFEDL-DKDKDGKLSREEVRPWALPDNnevav 268
gi 668457686 202 qmlptILKQTLRDKDKNNDGRIDFQEFVGDNAMDHdkew---lvvEMDKFKEDfDRDGDGYLNGNEILSWVVPSNdevat 278
gi 560117982 177 hmhkvLVEVTMKEKDANKDGAIDLKEFLGEMADNEhsdw---htvEKDRFLAEyDSDGDGVLRGDEVRRWLIPDVkavak 253
gi 442626081 211 qmlpiLLEHTMQDKDADHDGKINFQEFVGDAASHHdkew---litEKERFDKDhDSNGDGVLTGDEVLSWIVPSNtaian 287
gi 685830121 192 hmhgvLIQHTLIDKDKNNDGKISFEEYMHETQGSSdsew---yqvEKDRFEKEyDKNKDGLLDEEEIKKWLIPDLketak 268
gi 546671555 211 dlsalLLKQILRSKDTDNDDALNFKEFLSEKGSQMskea---lisQKDEFDEY-DMNKDGKLTGDEIIYWMFPQNekiae 286
gi 91082161  200 smlpiILEQTLRDKDKDGDKSISFQEFVGDRAHEHdkew---lqvEKDKFDHDlDKDGDGKLTSNEILSWIVPSNeeiae 276
gi 170592817 195 hmhaaLIEVTMKEKDKNHDGKITLDEFLDDLAGDQksdw---ymvEKNRFEYDyDKDRNGVLEGAEIASWLVMNLettaa 271
                        250       260       270
                 ....*....|....*....|....*....|..
Feature 1                                        
gi 646708580 298 eEVSHLFAASDDDHDELLTFDEILDHHEIFVG 329
gi 675365148 278 tEADHLIGSSDSNKDGRLSVDEIVDHHEIFVG 309
gi 684384432 284 eEAEHLFSETDANGDKELSKEEVLAQHELWVG 315
gi 607366850 296 dEVDHLFAGSDDDHDNRLSFDEILDHHDIFVG 327
gi 676422156 269 dEVLHLISQADDNKNNELTLAEILEHYDDFVG 300
gi 524902959 269 eEAEHLLESCDEDGDKQLTIDEIVSKEEEFLA 300
gi 668457686 279 dEVDHLFAASDDDHDDRLSHQEIIEKYDIFVG 310
gi 560117982 254 qEATHLINGADKDKDGKLSIAEIVDAYELFVG 285
gi 442626081 288 dEVDHLFVSTDEDHDDRLSYLEILNNYDTFVG 319
gi 685830121 269 tEADHLMDKADMDKNLELTYSEIVGAHQTFVG 300
gi 546671555 287 eETTHLFAQCDDNHDDLLSFDEILDHHEIFVG 318
gi 91082161  277 eEVDHLFASSDDDHNDVLSFDEVVEHHETFVG 308
gi 170592817 272 eEVEHLMSKADKDNDGRLSIDEIISESDLFVG 303

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