Conserved Protein Domain Family
EFh_CREC_RCN3

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cd16230: EFh_CREC_RCN3 
EF-hand, calcium binding motif, found in reticulocalbin-3 (RCN-3)
RCN-3, also termed EF-hand calcium-binding protein RLP49, is a putative six EF-hand Ca2+-binding protein that contains five RXXR (X is any amino acid) motifs and a C-terminal ER retrieval signal His-Asp-Glu-Leu (HDEL) tetrapeptide. The RXXR motif represents the target sequence of subtilisin-like proprotein convertases (SPCs). RCN-3 is specifically bound to the paired basic amino-acid-cleaving enzyme-4 (PACE4) precursor protein and plays an important role in the biosynthesis of PACE4.
Statistics
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PSSM-Id: 320028
View PSSM: cd16230
Aligned: 3 rows
Threshold Bit Score: 488.329
Threshold Setting Gi: 909784787
Created: 29-Apr-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
  next features
Feature 1:putative N-glycosylation site [posttranslational modification site]
Evidence:
  • Comment:RCN-3 possesses one potential N-glycosylation site at Asn140.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 30316268   44 PHDDAHGNFQYDHEAFLGREVAKEFDQLTPeesqaRLGRIVDRMDraGDGDGWVSLAELRAWIAHTQqrhirdSVSAAWD 123
gi 30316203   44 PHDDAHGNFQYDHEAFLGRDVAKEFDKLSPeesqaRLGRIVDRMDlaGDSDGWVSLAELRAWIAHTQqrhirdSVSAAWH 123
gi 909784787  10 AHHDHADGFAYDHEAFLGPEEARTFDQLSPsesqrRLGLLVGLID--GDGDGAVTTEELRGWIERTQrrareeSLRRGWQ 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                        #                                                               
gi 30316268  124 TYDTDRDGRVGWEELRNATYGHYapgeefhdvedaetykkmlaRDERRFRVADQDGDSMATREELTAFLHPEEfphmrdi 203
gi 30316203  124 TYDTDRDGRVGWEELRNATYGHYepgeefhdvedaetykkmlaRDERRFRVADQDGDSMATREELTAFLHPEEfphmrdi 203
gi 909784787  88 RYDRDSDGIVTWDEYRREAYGHPeddfegtqh--petyrqllaRDERRFRAADKDGDGGANRTEFAAFLHPEDfehmrpl 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 30316268  204 VIAETLEDLDRNKDGYVQVEEYIADLYSAEpgeeepawvqtERQQFRDFRDLNKDGHLDGSEVGHWVLPPAqdqplvEAN 283
gi 30316203  204 VVAETLEDLDKNKDGYVQVEEYIADLYSEEpgeeepawvqtERQQFREFRDLNKDGRLDGSEVGYWVLPPSqdqplvEAN 283
gi 909784787 166 VVTETMEDMDKDGDGFVHVDEYIAELYTGTpgtpepqwvqeERVQFVQARDRDGDGRLDPSEVGHWLRPPSpdwagvEAA 245
                        250       260
                 ....*....|....*....|....*...
Feature 1                                    
gi 30316268  284 HLLHESDTDKDGRLSKAEILGNWNMFVG 311
gi 30316203  284 HLLHESDTDKDGRLSKAEILSNWNMFVG 311
gi 909784787 246 HLLHHSDVDKDGQLTKAEILGNWQMFVG 273

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