Conserved Protein Domain Family
EFh_SPARC_SMOC1

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cd16240: EFh_SPARC_SMOC1 
EF-hand, extracellular calcium-binding (EC) motif, found in secreted modular calcium-binding protein 1 (SMOC-1)
SMOC-1, also termed SPARC-related modular calcium-binding protein 1, or smooth muscle-associated protein 1 (SMAP-1), is an Arf6 GTPase-activating protein (GAP) that directly interacts with clathrin and regulates the clathrin-dependent endocytosis of transferrin receptors from the plasma membrane. It is predominantly localized in basement membranes. SMOC-1 acts as a regulator of osteoblast differentiation and is involved in inhibition of transforming growth factor-beta (TGF-beta) signaling through production of nitric oxide. It also plays an essential role in ocular and limb development and functions as a regulator of bone morphogenic protein (BMP) signaling. It interacts with a matricellular protein, tenascin C in addition to the serum proteins, fibulin-1 and C-reactive protein, but not collagens. Two point mutations in the SMOC1 gene may cause Waardenburg Anophtalmia Syndrome. Moreover, SMOC-1 is involved in direct or indirect modulation of growth factor signaling pathways and plays a role in physiological processes involving extensive tissue remodeling. SMOC-1 contains a follistatin-like (FS) domain, two thyroglobulin-like (TY) domains, a novel domain, which is found only in the homologous SMOC-2, and an extracellular calcium-binding (EC) domain with two EF-hand calcium-binding motifs.
Statistics
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PSSM-Id: 320019
View PSSM: cd16240
Aligned: 4 rows
Threshold Bit Score: 238.393
Threshold Setting Gi: 161898543
Created: 18-Nov-2014
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Feature 1:Ca binding site [ion binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens SPARC (1SRA) binds two Ca2+ ions.
  • Citation:PMID 8119487

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 # # #      #           
gi 38258649  315 CPEGKKMEFITSLLDALTTDMVQAInsaaptgggrfsepdpshtlEERVVHWYFSQLDSNSSNDINKREMKPFKRYVKkk 394
gi 161898543 325 CPEGKKLEFITSLLDALTTDMVQAInsaapaaggrfsepdpnhtlEERVVLWYFSQLDSNASEDINKKEMKPFKRYVKkk 404
gi 677467272 156 CPEGKKVEFITSLLDALTTDMVQAInsaaptgggrfsepdpshtlEERVVHWYFSQLDNNSSNDINKRELKPFKRYVKkk 235
gi 82272054  316 CPEGKKLEFITSLLDALTTDMVHAInspapsgggrfvepdpshtlEERVVHWYFAQLDNNGSHDINKKELKPFKRYLKkk 395
                         90       100       110
                 ....*....|....*....|....*....|....*
Feature 1                      # # #      #         
gi 38258649  395 akPKKCARRFTDYCDLNKDKVISLPELKGCLGVSK 429
gi 161898543 405 akPKKCARRFTDYCDLNKDKSISFPELKGCLGVRK 439
gi 677467272 236 akPKKCARRFTDYCDLNKDKSISLQELKGCLGVSK 270
gi 82272054  396 akPKKCSRKFSDYCDLNKDRAISLQELKGCLGVSK 430

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