Conserved Protein Domain Family
EFh_SPARC_SMOC2

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cd16241: EFh_SPARC_SMOC2 
EF-hand, extracellular calcium-binding (EC) motif, found in secreted modular calcium-binding protein 2 (SMOC-2)
SMOC-2, also termed SPARC-related modular calcium-binding protein 2, or smooth muscle-associated protein 2 (SMAP-2), is a ubiquitously expressed matricellular protein that enhances the response to angiogenic growth factors, mediate cell adhesion, keratinocyte migration, and metastasis. It is also associated with vitiligo and craniofacial and dental defects. Moreover, SMOC-2 acts as an Arf1 GTPase-activating protein (GAP) that interacts with clathrin heavy chain (CHC) and clathrin assembly protein CALM and functions in the retrograde, early endosome/trans-Golgi network (TGN) pathway in a clathrin- and AP-1-dependent manner. It also contributes to mitogenesis via activation of integrin-linked kinase (ILK). SMOC-2 contains a follistatin-like (FS) domain, two thyroglobulin-like (TY) domains, a novel domain, which is found only in the homologous SMOC-1, and an extracellular calcium-binding (EC) domain with two EF-hand calcium-binding motifs.
Statistics
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PSSM-Id: 320020
View PSSM: cd16241
Aligned: 3 rows
Threshold Bit Score: 219.171
Threshold Setting Gi: 363747716
Created: 18-Nov-2014
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Feature 1:Ca binding site [ion binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens SPARC (1SRA) binds two Ca2+ ions.
  • Citation:PMID 8119487

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                # # #      #            
gi 38258648  304 CPGAKKHEFLTSVLDALSTDMVHAAsdpssssgrlsepdpshtlEERVVHWYFKLLDKNSSGDIGKKEIKPFKRFLRkks 383
gi 363747716 295 CPGEKKTEFLTSVLDALSTDMVHAVtdpaaggrm-lepdpshtlEERVVHWYFSQLDKNSSGDIGKKEIKPFKRLLRkks 373
gi 677143463  92 CPGAKKNEFLTSVLDALSTDMVHAVsdpslsssrvsepdpnhtlEERVVHWYFKQLDKNSSGDIGKKEIKPFKRFLRkks 171
                         90       100       110
                 ....*....|....*....|....*....|....
Feature 1                     # # #      #         
gi 38258648  384 kPKKCVKKFVEYCDVNNDKSISVQELMGCLGVAK 417
gi 363747716 374 kPKKCVKKFVEYCDISNDKALSLQELMGCLGVTK 407
gi 677143463 172 kPKKCVKKFVEYCDVNNDKSLSVQELMGCLGVTK 205

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