Conserved Protein Domain Family
EFh_DAH

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cd16245: EFh_DAH 
EF-hand-like motif found in Drosophila melanogaster discontinuous actin hexagon (DAH) and similar proteins
DAH, the product of the dah (discontinuous actin hexagon) gene, is a Drosophila homolog to vertebrate dystrotelin. It is tightly membrane-associated and highly phosphorylated in a time-dependent fashion. DAH plays an essential role in the process of cellularization, and is associated with vesicles that convene at the cleavage furrow. The absence of DAH leads the severe disruption of the cleavage furrows around the nuclei and development stalls. DAH contains a compact cluster of domains comprising four EF-hand-like motifs and a ZZ-domain, followed by a looser region with two coiled-coils.
Statistics
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PSSM-Id: 320003
View PSSM: cd16245
Aligned: 9 rows
Threshold Bit Score: 209.46
Threshold Setting Gi: 321463512
Created: 10-Feb-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Feature 1:EF-hand-like motif [structural motif]
Evidence:
  • Comment:The EF-like motifs don't contain the canonical pattern of calcium binding residues.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          ###############   #######################                                       
gi 74873395     81 PYKLVLAILDRHNLSg-gLELMVPPFQLTSLLHDVYFACEKlghfnq-danykLDRATGLLANFFWNVYD-PQRRHSISL 157
gi 321463512    45 QIFRIIDEFGLRSSE---KDLILTMDEIRQMVLNIYFLAQKsqlv-----hldYKVSSRIVLDLISETFDkSCRKKGCTL 116
gi 212513169    52 SLNLIMGVFEKHQYTkseNFSCIQQDDAKLIISDIYYAVQKikne-----einVNSFCNLLTSLVLHIYD-GEGKNSVSV 125
gi 642928840    69 TLSTVMGVFAKHKLGmneSSLCLESYDLEAVLYDIFFAANKrnnk-----nidVDFAVELMQNFLYNIYD-KERQVKIQV 142
gi 607367083    38 QLEIIAGVFERHRLSiteNCVNLDSSEIEDVLFDIYFAAQKesns-----nfdVNAATKLATSYILNTFN-KQQTGNILV 111
gi 122106543    67 PFQTVCTILDRHRLNqidSAPSIKPIQLTAVLHDVYFAAEQlgcftdltqppdREAMMATLAGLFWAVFD-PKRCNPLSI 145
gi 357618534    68 PLRISSGVFARHQLSlseTSLSLDTAELEAVLADIYFAAEKeglf-----tgdVDLSVDLLINLLLNVYD-GERKSPIRV 141
gi 1041543004   95 PVKIIAGVFDKHQMRtteNNLELSSSELEDIIYDILFATHTstpqq---slinVDLNTELILNFLLSVFD-SARRKSVRV 170
gi 498962420    73 PYKLVQALMDRYKILnvdANLMIPPFQLTTFIHDLYHACETlghfsk-sstynIETATSVLATFFWNLFD-PNRRHSISV 150
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                          
gi 74873395    158 LEIRITFILlcklysSDHLVGDIFGLLaDPKSQIISRYAFEQLLATLSKLLSYlgeakaygvhnlPLAMEQCFARCPHGV 237
gi 321463512   117 LDFLVFFTIlcgettLGEKYRRLLHLI-SDHNNCIQRRSLALLLKSIASLAHLvneapafghwtvLAAVQQCFEQCESPV 195
gi 212513169   126 LSLKIFLTVlcg-srPKMKYLYCFQQL-ADENNCLSKKKLEVLLKSIIKVLEYigeqcsfgsdliEGTIESCFQNCHKVN 203
gi 642928840   143 SSTKLALALlsd-ceLSELYNFIFSLC-ADHNNCVTRLRLQSLLTKLVEIMVFmhedvsfgqhliNSTIEHCFSNSPGLV 220
gi 607367083   112 FSVKVALVLlcs-gkLQEKYGYLYQQL-ADHNACLSRAGLYTLLTNICKITESlgedvtygckqiQSHIDACFVKSQGSL 189
gi 122106543   146 LELKQTFLLlcesqnFEQVVWEHFQLT-SDHNLCVSRHRFEAMLMNLAKLLSFlgepdhlkaklvQEIVNECFVNYPGLV 224
gi 357618534   142 LAAKTLLILlse-dsISEKWLALANCC-ADHNGCVSRKRLAALLIHVTALPKYlgcq----cdylENDVDNCFEKSAGML 215
gi 1041543004  171 LCSKVVLTIlca-ssMQSKIHYLFEQL-SDHNHCISKRKMECFLQCCSALMYYlaeslafsssliKPALRACFQGNDKFV 248
gi 498962420   151 LEIKVMFLLlckhigFFDWSTEFYNLLhDPKTRCVPKKNFKYLINILTKVFSYlgedngygphniELIMEKCFAKSHNLY 230
                          170
                   ....*....|...
Feature 1                       
gi 74873395    238 GGLtEPQFHKLWT 250
gi 321463512   196 GVP-EDVVFGWMV 207
gi 212513169   204 DIT-EYDFISWLI 215
gi 642928840   221 GLS-ENNFITWLE 232
gi 607367083   190 GIT-EAEFAAWIM 201
gi 122106543   225 GLT-EYQFSCLWK 236
gi 357618534   216 GIS-AHTVAEWGT 227
gi 1041543004  249 GLT-EDAFVRWFL 260
gi 498962420   231 GLT-EYQFKNLWC 242

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