3FFV


Conserved Protein Domain Family
Syd

?
cd16323: Syd 
Click on image for an interactive view with Cn3D
Syd, a SecY-interacting protein
This family contains the Syd protein that has been implicated in the Sec-dependent transport of polypeptides across the inner membrane in bacteria. Syd has been shown to bind the SecY subunit of membrane-embedded SecYEG heterotrimer (also known as core translocon or SecY complex) which is a conserved protein-conducting channel essential for the biogenesis of most of the secretory and integral membrane proteins. The SecY-binding site of Syd is a conserved concave and electronegative groove that forms interactions with the electropositive loops of the SecY subunit. Syd is also known to verify the proper assembly of the SecY complex in the membrane by interfering with protein translocation only when the channel displays abnormal SecY-SecE associations. Operon analysis has shown that Syd protein may function as immunity protein in bacterial toxin systems.
Statistics
?
PSSM-Id: 319993
View PSSM: cd16323
Aligned: 123 rows
Threshold Bit Score: 129.172
Threshold Setting Gi: 507764343
Created: 29-Mar-2013
Updated: 18-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3FFV_A         6 AQALKDFTARYCDAWheehkSWPLSEelygv----pspciISTTe-dAVYWQPQpftgeqnVNAVERAFdiviQPTIHTF 80
gi 528202750   4 INSLKEYFETLHNYWnssygTLPQVPfdelin--pmlyqgEPDEe-eYVSWLPKlketnedFKAIESDIglclHSSIKEY 80
gi 704827626   2 KQAFNIYFGKLLDKWreynnSLPQISfneevd--efmyesKEDEy-gYVFWKPKekrelfnFDEVESQCnvqlHNSIKQY 78
gi 926570252   3 IRSMENYFDRYITTWkefngTLPQTSwlgeeg--qrlyvgEKDKe-gYISWLPTkkdditsFHSIEQKFnirfNESVEQY 79
gi 859505066   4 KKALDRYFKALMNVWekkygTYPKVPwdaevd--sllylsNPDEe-gYVYWKPLeknnidnFIEIEKELsvniHDAIKEY 80
gi 910842551   4 KGIMTDYFERLLDYWnqnynTFPKAPwdeemh---pllyvSEPDeeeYIFWKPVekkdvenFSAIETEIrmplHYSIKDY 80
gi 228759444   4 KKALEHYYKELINVWatkygTYPKVPwdeeid--pllylsNPDEe-eYVYWKPIekidldnFTEIEKKLgmniHHAMKEY 80
gi 873987725   4 KAAMTDYFEKLLDYWnenynTFPKAPwdeeih---pllyvSEPDeeeYVFWKPVekkavenFSVIEAEIkmplHHSIKEY 80
gi 873987728   2 KHVMKQYFKKLTGKWeefngTLPLISwneeada-hiyvgsQDEEg--YIAWKPLekyentnFQQFEQEInvilHNDVKAY 78
gi 524216324   4 KKAFEKFFEEMTQNYlnewgVPPRVPyteknptglflpetLNDKg--YAQWKPKlqekpvsFDAMEKELgfsiHPQIKAF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3FFV_A        81 YTtQFAGDMHAQFg--dIKLTLLQTWs---eDDFRRVQENLIGHLVTQKrlklPPTLFIATLee----elEVISVCNlSG 151
gi 528202750  81 FNsYWFLELQGFFhsklIHLEPVEPG-----KDLRNFFVNQKTYEENQGk--qLKNIHIGFIsp----ddLALVINNeTG 149
gi 704827626  79 FNsCWFLELTGYFs--sYHINLHPVIp---gVEPDYFISILKDYVESQHd--iLKYIPIGFEsn-----gMLIVLDNnTG 146
gi 926570252  80 YNsYYFFQIAGWIk--eYNINLNPVIp---eSEPETFLQRLSNYIEEHN----GENNYIPMGies---ngLVVVLNNiSG 147
gi 859505066  81 FNsYWFLDIQGFYg---TKLVVLEPVep--nKSIVEFIQIMKRYEESEG----REFRYIQIGfvs--pedRAIIFDNeTG 149
gi 910842551  81 FNsYLFLSLEGLYhsnyIYLEPVEPD-----KDLLSYFKNLKNYEESQG----KEFRYVQIGfvs--pdeMAINVDNeTG 149
gi 228759444  81 FNsYWFLSLQGFYgsrlVNLEPVEPG-----KSILEFFQVMKQYEEKNG----RELRYIQIGfvs--pedMAIIFDNeTG 149
gi 873987725  81 FNsYLFLSLEGLYh--sKYICLEPVEp---gKDVQSYFKHLTHYDESQG----KEFRYIQIGfis--pdeMAINIDNkTG 149
gi 873987728  79 FNaYWFLEMIGWVs--qYNINLYPVIp---gVEPETFCQRVKEYILEKEn---STYIPLGFEsn-----gMLVVMNNeSG 145
gi 524216324  82 LStYWFLALDGIIqtsrGEAELRLNGltpysNLGKHIIFAFDNKETHYLh--nQKYFLIGTFcsiggndsYLVQVNNdTG 159
                        170       180
                 ....*....|....*....|....*.
3FFV_A       152 EVCKETLGtrKRTHLAsnLAEFLNQL 177
gi 528202750 150 EVLQENFEtgELTVIAesLEMLISEL 175
gi 704827626 147 EIFIEDFElnEYKPLSksLDQLIQGL 172
gi 926570252 148 EVCLEDFEagRFESLGlrLDELILNL 173
gi 859505066 150 EVLIENFEteEKEFLSnsLVELISNL 175
gi 910842551 150 KIYIEDYEtnELKLLArsLEELIGEI 175
gi 228759444 150 QILIENFEteENEFLAnsLAELINNL 175
gi 873987725 150 KVYIEDYEtnQLALLEnsLEELIGKI 175
gi 873987728 146 EIFVENDEekSYKYLSssLKELISQL 171
gi 524216324 160 EVTAVDVMnkRSVHLAdsIEELLCNM 185
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap