1IWM,3WJT,3WJV


Conserved Protein Domain Family
LolB

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cd16326: LolB 
Click on image for an interactive view with Cn3D
LolB, an outer membrane lipoprotein receptor
This family contains the outer membrane lipoprotein receptor, LolB, which catalyzes the last step of lipoprotein transfer from the inner to the outer membrane. There are five Lol proteins (LolA, LolB, LolC, LolD, and LolE) involved in the sorting and membrane localization of lipoprotein and are highly conserved in Gram-negative bacteria. LolA transports lipoproteins through the periplasm to LolB, which then localizes them to outer membranes; the protruding loop of LolB has been shown to be essential for the localization of lipoproteins in the anchoring of bacterial triacylated proteins to the outer membrane.
Statistics
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PSSM-Id: 319984
View PSSM: cd16326
Aligned: 411 rows
Threshold Bit Score: 81.1166
Threshold Setting Gi: 557642617
Created: 28-Mar-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
hydrophobiclipid binding
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:hydrophobic core
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                # # # #              #    # #         # #           # # 
1IWM_A        19 RQHQQDVRNl----------nQYQTRGAFAYIsd------qqKVYA---RFFWQQTgqdRYRLLLt---nPLGSTELELN 76
gi 171193736 317 PTLKETLERfkpdwtrddqsaKGSWDGRFAVKvtgltdaqnqGGSG---GFTLAQEa-lKDVLEIr---nPMGGSIAKII 389
gi 196193156  28 LQESSYVPTspe------tlnEWMVEGQFVLRad------giKSKS---YFYFKQLg-eNYQLAVlm-ddPVGAPKAVIS 90
gi 494661201  81 QTQQLSLAQl----------nEFGLQGSVAFFdda----advRDAA---RFNWDKSp-dETTFRLy---hQLGGTLARLQ 139
gi 495589553  20 ATHIPDPNQpl---------eSYTAIGRAALKa--------pNNSGq-aSFNWQQIspeNLKVIIq---gPLGSGRIDLV 78
gi 524780876  20 ALSTPELEQsw--------qgRFSLIARSASQq--------eNHSG---RFTLTQA---NTDLTIldlksALGNTLARIT 77
gi 686993218  26 LKESDYVPKspe------tlsEWMVEGAMELRan------gvKSKS---NFYFKQId-eNYELAIlg-dnPVGKPKAVIR 88
gi 770466343  29 KSHSPAIETlqaide-nrfieKFSIKAKFAYSvd------skGGSG---RLIWRYEn-nQDEIDIf---sPFNSQVAKII 94
gi 916697653  14 LCACAQLPPap--------taGYALSGRLSIRe---------GNSAqqaLFSWQSAp-dEDRLSLd---sPLGQTLALLT 72
gi 919191312  17 ASTPQATRA------------GYSASGRVALKva------neRHYA---QFDWHQLg-eQSELSLs---gPLGQTAAELR 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   # #                                                                  
1IWM_A        77 Aqp----gnVQLVDNk---gQRYTAddaEEMIGKLTGMpIPLNSLRQWILGlpg-------------datDYKLDdqy-- 134
gi 171193736 390 It------pGEATLEsd--gKVVTAadaDTLVQNTLGLpLPARGLSNWLRGevr-------------pgsEASVDrnak- 447
gi 196193156  91 Gnvy---apQEETLDv---iGGASA---KKVAEHLHAQ-LQAGDLSYWVRGl------------------PATANaviyq 142
gi 494661201 140 Qt-------KSISVLidrdgNRYEGsdlNLLLLQHTGMvIPFSLLNQAITGaepdarlrqtrwyangalaTYEAEft--- 209
gi 495589553  79 Vt------pTESTLKtd--dQTYKSespDVLFSEITGFdWPISGMTSWIVGepga------------astLVKRDa---- 134
gi 524780876  78 Qt------pTEVSLEtlgnpTVYANd-aESLLLKSLGFsVPVDGLNYWIDGkv---------------ipNQAAStips- 134
gi 686993218  89 Gniy---epESEMLDv---iGGYEA---EKVAQHFQSV-MKASSLSYWVRGl------------------PATADanvtq 140
gi 770466343  95 Yss-----nDKRIIDan--gKVLSGddfDRYIQSLFGKnISPDLFRHLITNhvd-------------qikNLHKDe---- 150
gi 916697653  73 IryrpdgqaAEAILErggeaPEYASd-pRALLLSLTGLdLPLNGLRWWLQGeaa-------------pfsSARRDeqd-- 136
gi 919191312  72 Fs------pGRASFRga-nqREITAnsaDELILEALGWpLPVSGLRWWLRGepdpe---------lavtsQSEIEn---- 131
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                #            # #               #  # #            # # #    #  
1IWM_A       135 ----rlSEITYsqn--gknWKVVYGGYdtkt----qpaMPANMELTDg------gQRIKLKMd--NWIV 185
gi 171193736 448 ---gqvNKIIQd------gWNLVYTWSnt--------nRLEKLTMTRssn--igsIDIRLAF---DRPN 494
gi 196193156 143 enlylpESIEEn------gWKIAYQDYmsvq---ggyrLPADMEMKSe------gASLDLELv--RAET 194
gi 494661201 210 ----lgAWAQQr-------WLLEFGDYrhvpygnqpllLPHRIEASRd------nIRVHLRVs--RWRP 259
gi 495589553 135 -----qNRIESfde---dgWHVEYKKWghyk----qrdIPKTIELTRd------nVRLRLLVe--HWLY 183
gi 524780876 135 --appyNQVKQs------gWLITYENYde-------sgLPKRIRLTReatsftpsISILLVVssrDHDS 188
gi 686993218 141 qgtnlaKKIEEd------gWKIYFHDYmsvt---gnykLPAEIKFNGd------kKELRLDLv--RAET 192
gi 770466343 151 ------NQLNRtthfyndeWNILINAFktqd----gltIPSKISITQg------tFSFNFIV---EEII 200
gi 916697653 137 ----giVTVSQd------gWTIVSQDYrplg----krqQPFRLNAQRd------eVQLRIVIs--EAST 183
gi 919191312 132 -----gRLLLQa------gWHIESSDYrgq------psLPHKLTLSRs------dLEIKVVIs--EWQW 175

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