1OR7


Conserved Protein Domain Family
RseA_N

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cd16328: RseA_N 
Click on image for an interactive view with Cn3D
N-terminal domain of RseA
This family contains the cytoplasmic (N-terminal) domain of RseA, the transmembrane anti-sigma-E factor. RseA is degraded during sigma-E-dependent transcription caused by bacterial envelope stress such as heat shock. It is an inner membrane protein with an N-terminal cytoplasmic domain that binds sigma-E and blocks its transcriptional activity, and a C-terminal periplasmic domain that binds RseB, an auxiliary negative regulator. Under inducing conditions, RseA is rapidly degraded and sigma-E is released into the cytoplasm, where it can bind core RNAP and induce its regulon. It has been shown that just the N-terminal domain is sufficient to bind and inhibit sigma-E. The C-terminal domain may interact with other proteins that signal periplasmic stress.
Statistics
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PSSM-Id: 319992
View PSSM: cd16328
Aligned: 289 rows
Threshold Bit Score: 49.1115
Threshold Setting Gi: 913424271
Created: 29-Mar-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
heterodimer
Conserved site includes 34 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1OR7: Escherichia coli sigmaE binds the cytoplasmic domain of its anti-sigma RseA; contacts at 4.0A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
Feature 1        ##  #######        ## ##         # ############         ### ### ## 
1OR7_C         3 KEQLSALMDGEtl--dsELLNELAhn---peMQKTWESYHLIRDSMRGDtpevlhfDISSRVMAAIE 64
gi 741164421   5 QEKLSAFMDGEi-----EGNDIIDaikhdeaLQAKWQRYHVYRGAMRKEasvapqlDITASVAAALE 66
gi 494897323   5 FENLSALVDGEdststsSSSHVLDavkndaeLQLKWKSYHLIRDGLRQElpaninfDIADRVAQALE 71
gi 651237538   5 QEHLSAIIDGEh-----QDDALIAsiasdsqLAERWHRYHVVRAALRKEmplnghfDISASVADALE 66
gi 517522946   6 NEKLSAFVDNElt---tEEMQCLEld---evQQSTWMRYNLIGDVMRDDvpaqlqfDITDRIADALE 66
gi 410158594   5 LEKLSAFVDGEhh--dpDIAKSLTqd---pgLADKWKRYHLVRDCIRREmsadihfDISAEIAKKLE 66
gi 410142961   5 HENLSAFIDGEaqd-gnFVSNLINdd----eMGAKWHRYHIIRQTLRKEmpqnadfDISASIAVALE 66
gi 88819826   13 NEHLSALLDGEt----pLTDQILTa-----eDHKTFERYALIGDVVKAEqqtdifiDIADRVALALE 70
gi 798747981  11 KAFVSALVDNEv-----SLDDVQTdd----iDSQTLARYSLIGDAMRSEtapsiqlDIAASVAKQLE 68
gi 754778890  11 KAEISAFLDAEe-----GMSDFMAqs----eAGKTLERYSLIGDAMRADdkdfihlDIASKVASQLE 68

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