3BK5,4Z48,3BUU


Conserved Protein Domain Family
LolA_like

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cd16329: LolA_like 
Click on image for an interactive view with Cn3D
proteins similar to periplasmic molecular chaperone LolA, the outer membrane lipoprotein receptor LolB and the periplasmic protein RseB
This family contains uncharacterized proteins similar to the periplasmic molecular chaperone LolA, the outer membrane lipoprotein receptor LolB and the periplasmic protein RseB, all of which have similar unclosed beta-barrel structures that resemble a baseball glove-like scaffold consisting of an 11-stranded antiparallel sheet. There are five Lol proteins (LolA, LolB, LolC, LolD, and LolE) involved in the sorting and membrane localization of lipoprotein and are highly conserved in Gram-negative bacteria. LolA accepts outer membrane (OM)-specific lipoproteins that are released from the inner membrane by the LolCDE complex and transfers them to the OM receptor LolB. It is proposed that the LolA/LolB complex forms a tunnel-like structure, where the hydrophobic insides of LolA and LolB are connected, which enables lipoproteins to transfer from LolA to LolB. RseB exerts a crucial role in modulating the stability of RseA, the transmembrane anti-sigma-factor that is degraded during sigma-E-dependent transcription caused by bacterial envelope stress. Its structural similarity to LolA and LolB suggests that RseA may act as a sensor of periplasmic stress with a dual functionality, detecting mislocalized lipoproteins as well as propagating the signal to induce the sigma-E-response.
Statistics
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PSSM-Id: 319986
View PSSM: cd16329
Aligned: 673 rows
Threshold Bit Score: 65.4142
Threshold Setting Gi: 505138928
Created: 8-Oct-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
hydrophobic
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:hydrophobic core
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                             # #        # #           #       # #                     # 
3BK5_A         5 KGLEIAQERKARdeg-wgDSIATX-------EXILKNa--qGESSTR------LXRLKSLEve--------gdGDKGLTI 60
gi 494035569  30 SASQLASQLSALr----qDGSSYVr-----lRMEIKG----GKAETL------QLQIKQRLtr---------gSSEVMYQ 81
gi 189186763  14 LSCFLWSKPNPDk----pSPPLEFiqgrfwrNFRLKDyilkGSIQAAkdtypiTLILHDRSmeyh-----fmgLPLQIHV 84
gi 910223124  27 GAAELAAKLSDLq----qDGSTFIr-----vKMIVSSpanpSDPKTTl-----QLQIKSRRsa---------gQTDVVYQ 83
gi 505138928  26 SAQSLLQDIIKQm-----DQVKDF-------KGTIVT----KVTSAD------KVYNFKTK------------VMKSRTR 71
gi 321165134  25 AAIAIARQRVEAt-----DSRASG-------HLVRVNa--nGKRVSNa----fTLEAHWFPg-----------VLRALIE 75
gi 521982899  25 LASVLWMSGFSRsafaapDPAKPCp------PLEFLQgrfwKNFRLQdfalhgVIESERESypiq----lilhDRKMIYD 94
gi 663075968   5 TAVAVLALTQGA------QNIQSFv------QPDLKDat-fVARKVKad--qrELRKINDSfgn------syrFDTTTIY 63
gi 503044050  29 SPDRIIKGILANf-----DQIKDF-------KGSLVSkiflAEETVT------YRTNIMKN------------QQRSLTD 78
gi 931398325   5 VRHVIVTAALTAl-----CSPAAIa-----qDLSLDEi--lNNHYAAlgg-ldNIRSITSRrmvgrmtlpqgmEATFTLL 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #                # #                # #                                         
3BK5_A        61 FDQPr--------DVTGTAFLNHShti---gaDDQWLYLPa-lKRVKRIss----rnKSGPFx--gSEFAYEDLs-sFEI 121
gi 494035569  82 VLFPk--------ERKGESVLLKRsak---ggASGASFTPp--NSMRQIsd-----lKEPLFg---SDLSYEDVi--DNF 138
gi 189186763  85 EINP---------DNTYVAYKNHP--------SDPWQPITg-fNRTKHIl------nTDISY----EDLCLDFIr-wDKI 135
gi 910223124  84 VLFPk--------ERKGEAVLISSs-------GNGATFTPp--DKLQTFda----akFKESLl--gSDLSYEDVs--DNF 138
gi 505138928  72 LMTQ---------HIKGSKFSASAgrl---lnTIPLLYLP---PDYSTIm-------TTLPIe---GQLDYQNPl--QNL 124
gi 321165134  76 IVPPrtpaenanqDARVSILLEMRpn----gqNTIQIFRPh--ESAPALlpf--dkwSESVFg---SDFNYEDF---LQP 141
gi 521982899  95 FLNPpfq---irvEIQPERSLVERr------rQKRDPWQP---VSGRSR--------QSPILd---TDITYEDLc--LDF 149
gi 663075968  64 FKEPf--------KVRLEASVEDT--------TVVYVLNGp--IQTIKMrsfhqrldLTGKPgrrqTPLDFGLLt-pSLF 124
gi 503044050  79 NSYTf-------gRIKGTASGRLLn-------AMPWIYLP---PDYSLLq-------NALPLr---GQRDYLEPl--NNL 129
gi 931398325  72 SKRPm--------KARMEFTLQGMtgvqaydgETAWMLMPfmgQTEPEI--------MPPDM----ADPMKEEAdfdGPL 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #             # #       
3BK5_A       122 EKY-----RFNHLKDekfngqdvFVLEQIPtd---knSGYTKQVVWLDKAhyrPLKVEFYDr-kGALLKTLTFANYkqy- 191
gi 494035569 139 YGWp----QQAIVGTeevegvncQVLESKPgkg--drSSYGSVKSWVDMRrmvPLRVEKYSe-sGKLVHRIDTTRVvsd- 210
gi 189186763 136 KPLgt--dSIKTLSC--------WAFEAYPgp---vpSAYAKVRYWIAEDyyaLLRVEGYNa-gGQIVKRLDINSVqri- 200
gi 910223124 139 FAWk----DQSLAGTetvsnvscQILESKPkg---arSSYTSVKSWIDTKrmvPLRVEKYGa-gGQLVRRIDTSDVanv- 209
gi 505138928 125 DKLy----KIKLLGE--------AIYQNREvyilqleNLFSTQRIYIDKErslITKIKVFN---SSNIKVADISYTdfel 189
gi 321165134 142 EFYw---qNQTILRSdkfgvhdcDVLKSVPegs--nrSHYVEVQTWLDHNinyPVYVEKTPk-dAAGVKEFTYSGLtqs- 214
gi 521982899 150 MRWd----NVRPLGTdhvktltaWAFDAVPpp---etSAYARVRYWIAAEyyaLLRADGYNk-aGALIKRLEVNGVqri- 220
gi 663075968 125 EGLf----QARFVRNdra--tgdVVFDLTYpe---rlDDTSRHRIWIDPQkkyVTKREWYNq-sGRQLATFIYENPkne- 193
gi 503044050 130 EDIy----NLKLLGE--------TNLHNKPitllelsNQFTRQVIWVEKErllIDKIEVFNg-aDQLVATINYNGYrev- 195
gi 931398325 132 VDYaekghKLALLGMedvegaqtYKLELTH-------KNGEITIFYLDADyflPIKSESERtmqGMEMHVETVLSDyke- 203
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
Feature 1               #  # #             # # #      #               
3BK5_A       192 -ldkYWRAHTXAXTNHq-----tGKSTELNTs----DLRFqt---gLEENDFN 231
gi 494035569 211 --agHSIPANLSVRGPh-----eNSTTLLDGsrirhDVNFtd--adLSAEGMK 254
gi 189186763 201 --gdAYVIKEMQIATIppgktlsSSKTYIQIee-gkPLSPk----eSENLDFS 246
gi 910223124 210 --dgRNVLAMLVIRRP-------GHATATEMdg--sRIKRgv---aYTDADFT 248
gi 505138928 190 fasqVWLPTKIKVDTLf-----nNSRLEIEYqd--wKVNLg-----LTSFDFA 230
gi 321165134 215 --ggVWAARQVGVKVRg-----rPGLTLLLIeh--gSTRAn-----LNIRDFS 253
gi 521982899 221 --gdAYVIKEMQVSSFdpk--keGSSRTFINi----RRGEp-----LSPEAGP 260
gi 663075968 194 --ggVWMPTRMTVKNVdn---rvAGITTYDSi----KTNTg-----LSDSMFQ 232
gi 503044050 196 -eneIWLPNLIIVENR-------NEEQILKI-----NYQNwvindgLDNEDFA 235
gi 931398325 204 -vdgMMIPHSLQILQGp------GSQTLTIE-----KVEHnv---eLDDAQFS 241

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