3RPU,3EUH


Conserved Protein Domain Family
MukF_N

?
cd16335: MukF_N 
Click on image for an interactive view with Cn3D
bacterial condensin complex subunit MukF, N-terminal domain
MukF is part of the MukBEF condensin complex that is mainly found in proteobacteria and is involved in chromosome organization and condensation. The complex is believed to serve as a part of the chromosome scaffold rather than a bulk DNA packing protein. MukE and MukF form a stable complex with each other and dynamically associate with MukB, a member of the SMC protein family. MukEF does not bind DNA on its own but modulates MukB-DNA activity. The stoichiometry of the MukEF complex is MukE4F2.
Statistics
?
PSSM-Id: 319981
View PSSM: cd16335
Aligned: 18 rows
Threshold Bit Score: 308.807
Threshold Setting Gi: 671507784
Created: 29-Mar-2013
Updated: 18-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
 
homodimerMukE-MukF
Conserved site includes 58 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          ##  ###### #  ##      # #                #               #                    
3RPU_A        33 AWARKNDFSISLPVDRLSFLLAVATLNger---------ldgEMSEGELVDAFRHVSDAFEqt---------seTIGVRA 94
gi 522070865  12 STILTQGISLKLQPADLAYLAALRYWKete---------sqpEFSEEELHVVFQSVEKARLddn--------sdDSSKRC 74
gi 521003472   8 ASLQRSRAALKLDTADLCYLVALRARAera---------alaSFEEDLLVDVFEQICEITDpg---------aeNPRKRA 69
gi 346059792  26 ASLVRDQVNLDLKTADVCFLAGLYLRAdka---------glaSFEEDLLIDLFEQVCDVVEpa---------aeNPRKRA 87
gi 736873155  12 SEILTSGQKIQLQPADLAFLAALRFWKdqe---------sqpEFSEEELHLVFETVDRQDLgal--------edSRQRRC 74
gi 913621233  11 TSLHRRGVALELHTLDLCFLAALHVRAers---------gmsSFQEDQLLDVFDQVVALTKegr-------gegGAKKRA 74
gi 671507784  56 RDLISRGFTYDLSPLEMAFLAGVVLWPdtdlql---sncadnHVEEAHLFEVYARVDGIFVahgdptlmdykvqTRDQRA 132
gi 516745496  14 QTVLDDGLSLDLWPRDVALLVLIQKKMnsgt-------gfsfAMEGGELRSLAAKVDGLEVkd---------ssGTEKRL 77
gi 752765518  12 NQVRMNEPALHIEPNEYLYLAAMSLWNvndddd---yrlvdpGYKEEQCNEIFSYVDRWLGqd----------dITSFRT 78
gi 738890825  20 FQISSRQPTLHLTTNEFSYLAAMTTWDlvtdeqdseyhfiqsGFDETTCHSIIRYVDERINed---------laTTDVRV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #     #####         # ##### # #  ## #       # ##  ##  #   #              
3RPU_A        95 NNAINDMVRqrLLNRFTSEQAe--GNAIYRLTPLGIGITDYYIRqr---efSTLRLSMQLSIVAGELKRAADAAEEggd- 168
gi 522070865  75 NDVIRRLLQqhLLICLEGGDQ---RNHAYLITPLSEQIVDSVCVgm---eaSQEALSTLFMTVASHLREIRDSAEQggn- 147
gi 521003472  70 THAIQRLREqrLLARVDGAGLv--RAGEYTLTRLAAAVVDFFFDde---alTRESLTLLTGVLAAQLVQVLGAARSaat- 143
gi 346059792  88 THAIQRLREqrMLARVDGAGIv--RAGEYALTRLAAAVIEYFLAde---alTRESLSLLTGTLRAQLADILATARKahn- 161
gi 736873155  75 NDTLRRLLEqhLLICLESGGK---RPHAYLLPPVSEQIVESICTgl---daSQTALRTLFTTVAGHLQEIHEAARQdgn- 147
gi 913621233  75 THVVRRLRDqkLLVRVDGAGVt--RAGEYALTRLATGIIGFYLEdd---alTRESLDVLAGTLTACLEGVLAATRAads- 148
gi 671507784 133 NHAVGRLVLmgLLRRITLSET---NQTLYSLSPVAHDLVDLAYNyrldeeaTKQSLSLSYREVRTELVALRERSDAind- 208
gi 516745496  78 TESINRLIRanCLARADLSRLrniEDTEYQLTSLGESIASWHIEh------TRFSGEPMAAILQVFNGQIVDLHAKalnl 151
gi 752765518  79 SNFLKRAVEqgLVMQAGSSLRn--ADGFYRLTQLSHDLLKPFTGdt---liQKESLSQRYVRLEILLGNLLVLKIEd--- 150
gi 738890825  91 NNFLKRALEqgLLSLAGTSVAd--VGGTYRLTQLAHDLLKPFHQpde--saDTETLSQRYLRIDHELSNLNALSDTeni- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #    ## ###  #  #   #  ## ## ##  #                                        
3RPU_A       169 --efHWHRNVYAPLKYSVAEIFDSIDLTQRLMDEQQQQVKDDIAQLLNk---DWRAAISSCELLLSETSGTLRELQDTLE 243
gi 522070865 148 --epFWKHQVESPLNITVNQLVTSIDHRQRQLDQEAINTRKEVVELLKq---DWQNSISQCEQLLTSTQSHLQDLQRLLL 222
gi 521003472 144 --aeAWRAEVVAPLQITVRDLVAGIERRQCGLDLQQEEIRERIGALLQs---DWFRAVETCEELLEATASTLRELNEVLL 218
gi 346059792 162 --deDWRQRVVAPLRITVGDMVAGIERRQRGLDAQQEEIQAEIASLLSn---DWFSAIDRCQSLLDATTHTLRELNEILL 236
gi 736873155 148 --dqFWKLQIEAPLDITVRQLVTAIDHRQRQLDTEAITTRKEVVSLLKh---DWQNAIARCEALLVDTQERLQDLQQLLL 222
gi 913621233 149 --eeAWRTGVIGPLRVTIFELAGGIERRQRGFDLQQEEFQREIAALLAa---DWFGAVERCTKLLDTTSAMLHELNDILL 223
gi 671507784 209 --pnEFTIHIGNRLRSLVSGALEQINRQQTMLLGSMDHNGRQLQEKVTqtrnIDMSVFTALFEMMQITAQQIQDLCDVMN 286
gi 516745496 152 egdeDWRRDILLPMQVVLKDMLVNVQRHQRELDRQHEALRAFIPTLLTe---NSEASIDQCEQQLTQVIRTIDDLQEVTL 228
gi 752765518 151 ---dEEWANEIKAQLPSFRDLLDGINKNQEALIKGFQLQRSSIQSAASg---SLAQQMQHLIELIDEIAGQIRDLKSLIL 224
gi 738890825 166 --ttEEWLEKVQCFLPSLKDLLEGVFRNQELLISRFHSMRSALQNGMDt---SLETEMQQLLEAVQTLAEQINDLRMLVM 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                              #   #      #                              
3RPU_A       244 AAGDKLQANLLRIqdatmthddlhfvdrLVFDLQSKLDRIISWGQQSIDLWIGYDRHVHKFIRTAIDMdknrVFAQRLRQ 323
gi 522070865 223 ASCHELRSLLEAIsrsceqs-qrsdainSVLRLEQHLDRIEHWSGERMNHWEGFHHRVHQYLRQFVTMderkALMERVRE 301
gi 521003472 219 RDTGHIQARLQEIeqlaadr-gtpeaaeAAQRAAEHVDRVSAWGRDRQRAWSEYYQYVQRFLRDVVRLdrdrALSQRLRD 297
gi 346059792 237 RDTHHFVALLQDIqalavsa-enveaegAAQRVIEHVDRIGAWGGARQKAWSEYYQYVHRYLRDVVRLdpdrALSQRLRD 315
gi 736873155 223 ASCHELRQLLESIgqhceka-qrlsavqSVVRLEHHLDRIEHWSSERLEHWENFHQRTHQYLRQFINMderkALMERTLD 301
gi 913621233 224 RHGHRFGELLQEVleragda-eqeeaerAARDALDQVERLAAWGAARQRAWSDYHEWVHRYLRDVVRLdpsrTLVHRLRE 302
gi 671507784 287 ETSGEIEASLNALiekagel-gldtqqqQLLMIQDNFSVHASWARQETIELIQFYRRLMAYLRSQLSIsqrqLFLDCLEL 365
gi 516745496 229 SSSSKAFELLYQIeiagenk-kiegvgpVCQDITRRMHSIVQWTAQRATDWVEHHGVVHDFLRSVIRId--rQRRLTEAL 305
gi 752765518 225 NGADNVLSLLHEIkemahnrnapirltnAMADIHDQLDSIRQFSGHSLLELAEFFEQVLSTIRLKITLdpnaNLNLLIEK 304
gi 738890825 241 NRADAVLMQLELLqssvvqkagsrplqnALSALFDSLMEVREFANHSLKDLTWFFDTVLDRVRIRIALdpnaNLGYLIDR 320
                        330       340
                 ....*....|....*....|....*
Feature 1                                 
3RPU_A       324 SVQTYFDEPWALTYANADRLLDMRD 348
gi 522070865 302 GIRNYQEMPWYLRYTHEEPLTRLRD 326
gi 521003472 298 QLVAWPDRPFALIAARAPSIRLLRP 322
gi 346059792 316 QIAEWGNRPFHLLAAHAGSICLLRT 340
gi 736873155 302 ALQRYDQHPWHLRCAGDEPLIRLRE 326
gi 913621233 303 QLAGRAGKRYALTIASAAPFTLLRS 327
gi 671507784 366 AIERFADQPWGLPIVERMPQVYLED 390
gi 516745496 306 KHAIAIPPDWSLRISLEPRLIRMRE 330
gi 752765518 305 AVLQMDRMPWSISILAPDPVVELRD 329
gi 738890825 321 TIRLFDGSSWSLALPSSIRLMQLRE 345

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap