3EUH,3RPU,3EUK


Conserved Protein Domain Family
MukE

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cd16336: MukE 
Click on image for an interactive view with Cn3D
bacterial condensin complex subunit MukE
MukE is part of the MukBEF condensin complex that is mainly found in proteobacteria and is involved in chromosome organization and condensation. The complex is believed to serve as a part of the chromosome scaffold rather than a bulk DNA packing protein. MukE and MukF form a stable complex with each other and dynamically associate with MukB, a member of the SMC protein family. MukEF does not bind DNA on its own but modulates MukB-DNA activity. The stoichiometry of the MukEF complex is MukE4F2.
Statistics
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PSSM-Id: 319980
View PSSM: cd16336
Aligned: 15 rows
Threshold Bit Score: 254.131
Threshold Setting Gi: 759481929
Created: 28-Mar-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
MukE-MukFhomodimer
Conserved site includes 49 residues -Click on image for an interactive view with Cn3D
Feature 1:MukE-MukF interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                            ####                                           #        ####
3EUH_C        10 MPVKLAQALANPLFPALDSALRSGRHIGLDELDNHAFLMDFQEYLEEFYARYNVELIRApeGFFYLRPRSTt--lIPRSV 87
3RPU_G        21 MPVKLAQALANPLFPALDSALRSGRHIGLDELDNHAFLMDFQEYLEEFYARYNVELIRApeGFFYLRPRSTt--lIPRSV 98
3EUK_L         9 IPAKLAIAIANPIFPQLDSQLRAGRHISIEMLDEHAFLMDFQTELESFYRRYHVDLIRApeGFFYLRPKASt--lIARSA 86
gi 917182560  15 PYNNLADIINDDLFAELDSRLRRGEHIDNRHTHFYAMLQNGEHWLMQHYRRYGVDLVRAqeDFYYLRPNLGsknlIRSRK 94
gi 736842929   5 PYQQIADLINDECFPELDTRLRRGEHIDARYHRLFNIIQDGFPLLAEYYLRFGSDLVQApeAYYYLRPGTSgkslIRSRK 84
gi 521995661   5 RYHSLESVISDPLFPCIDHRLRCGFHVDSDDIADYEFLLYAADWLQGFYAGYQCRLIQApeGYWYLRSEGEl---LGHRR 81
gi 522823125   5 SFSRLEEVVLDPLFPEVDLALRAGRHVDRDDGDRYSFLVDAQELLEPFYRRYGCELTHAteGYFYLLPSGDr---LGRRH 81
gi 913621234   5 RFATLEDVILDDAFPELDLALRRGRHIDRDDAIWYALLVDGQDHLEPLYRRYGCELVHKsdGYFYLLPINDr---LGKRH 81
gi 700312862  11 QFNTFLDVMKSPLFPVVDYKLRRGINILPADYMLYSFINQAFHPLCEYYDFLSLSLCFSneSVYYLLPQRRg--kIPLER 88
gi 500036354  15 QYLTLDDVIDDPLFADVDYRLRGGVNITSEDDRLHTFLGETESVLRKFYGKLHLALEVTpeKVYYLRPQRRs--nVPTTR 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        # #  ##  #  ## ## #  ######            #    #   #                             # 
3EUH_C        88 LSELDMMVGKILCYLYLSPerLANEGIFTqQELYDELltLADEAKLLKLVNnrst-gsdvDRQKLQEKVRSSLNRLRRLG 166
3RPU_G        99 LSELDMMVGKILCYLYLSPerLANEGIFTqQELYDELltLADEAKLLKLVNnrst-gsdvDRQKLQEKVRSSLNRLRRLG 177
3EUK_L        87 MSEMEMLVGKVLCYLYLSPerLAQQGIFSqDDVYEELlnLADENKLLKAVNprst-gsdlDRAKLAEKVGGALRRLARIG 165
gi 917182560  95 IDELGMLLGQLLALYHLDPeqLEGSGWITaDAIYERLrlLIDEERLAKLLDrkkl-dtqlDRDKGMEVLKRSLRQLARLG 173
gi 736842929  85 LDELTMIAGQVLAMFHLDPeqLEGSGWIStDAVYERLrlLLENDYLCQLLErkki-etqaDRDKAMETLRRAIRQLARLG 163
gi 521995661  82 LSLAEMLVGQVLALMHMDPvwLSQTGWIPrTKVLETLehLLGRERLAAQLAprsrarehhADDRRIREAVDKALNGLEAL 161
gi 522823125  82 LTAGEMLVGQTLALLYLDPatVQSGGVVPrAQLVARLegLIGRQRLVVALNprrkryderIAEETVRIEIDKALRALAAL 161
gi 913621234  82 LAAAEMLVGQALALLYLDPatVETGGIVTrEHVLGHLagVVGSDVLVQMMNpkrrrhderIAAETVRSKVADALRRLSAL 161
gi 700312862  89 FNELQMVTGLIIVAMELEKq-LSQKEWFTtNQLLERMsnQLSETRLLELFRrrpg-qqtqYDLSKIQDEIRKSLIVFDRY 166
gi 500036354  93 LNQLEMVMGLTIVAMQWEKn-ATDFEWIPvDFLIERLksQLSDERFAELYRrkpg-iqtdHDVGRVREETLKRLSRLSRL 170
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1            #               # #     #### ####    ##  #  #      #### #
3EUH_C       167 MVWFMGh----------dSSKFRITESVFRFGADVRA----GDDPREAQRRLIRDGEAMPI 213
3RPU_G       178 MVWFMGh----------dSSKFRITESVFRFGADVRA----GDDPREAQRRLIRDGEAMPI 224
3EUK_L       166 IITRVGeq---------nSKKFIISEAVFRFGADVRA----GDDPREVQLRLIRDGEATTP 213
gi 917182560 174 MIRLEGi----------rADQIQTQSPLMRFIEPVRS----AALTREALEQLVATGSVCLE 220
gi 736842929 164 MVRLEGn----------qANRLQTQAPLMRFIDPVRStastTEGTRAAMEQLVRDGYISLD 214
gi 521995661 162 GFVRQRr----------dTAELLPRRPLMRFVAAVRG----SADPREALERLVLEGEVEFG 208
gi 522823125 162 GFVDLQeeggrgaapaarAERLRVRAPVLRFAEPVRG----LGDRAEALGRLVAEGKVALG 218
gi 913621234 162 GFVDAAd-----------DARYRLRASLLRFAEPLRG----AGAPAAHLAELVAAGELVIE 207
gi 700312862 167 AFIQLSk----------dRQSFQTTPAIYRFIEPLRG----LQQESEIPQRLAELIQEGYL 213
gi 500036354 171 SFIRLNr----------dEQTFWATNAIYRFIEPLKG----LSSEDELPGRISSLIQEGFL 217

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