4TQ2,3BDR,4O4O,4O4S


Conserved Protein Domain Family
CpcS_T

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cd16340: CpcS_T 
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S- and T-type phycobiliprotein (PBP) lyases
This family contains the S- and T-type phycobiliprotein (PBP) lyases. PBP lyases are employed by cyanobacteria, red algae, cryptophytes and glaucophytes for light-harvesting. Pigmentation of light-harvesting phycobiliproteins of cyanobacteria and cryptophytes requires covalent attachment of open-chain tetrapyrrole chromophores, the phycobilins, to the apoproteins. PBP lyases mediate this covalent attachment of phycobilin chromophores to apo-PBPs. These lyases are distinguishable in the clades of E/F-, S/U-, and T-type lyases; T-type lyases (which include CpcT) are distantly related to S-type lyases (which include CpcS and CpcU). S- and T-type PBP lyases differ in mechanistic details; the conformation and protonation state in which the chromophore is presented account for their differences in stereochemistry of the chromophore selectivity as well as corresponding binding sites. On the other hand, both lyases carry out the main functions of assisting site selectivity in the apo-PBP, protecting the chromophore and ensuring the regio- and stereoselectivity of the addition. The S- and T-type PBP lyases adopt a beta-barrel structure with a modified lipocalin fold.
Statistics
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PSSM-Id: 319978
View PSSM: cd16340
Aligned: 4 rows
Threshold Bit Score: 164.416
Threshold Setting Gi: 672885843
Created: 30-Oct-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                   10        20        30        40        50        60        70        80
           ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4TQ2_A  20 EFFERSVGSWRSlrsshniafaqleevnSDIDITQVaaddsefldicktynfepekacSSIRMSWEGssdwdenevIKGS 99
3BDR_A   9 DFFAQSAGRWFSqrtshhlafkqtesgkSQLTIELLsvddpavialcqqydxdpawavCGARVSWDGtxew-dnekHEGS 87
4O4O_A   9 TLARWXAADFSNqaqafen---ppfyahIRVCXRPLpwev---------------lsgVGFFVEQAYdyx---lndPYRL 67
4O4S_A   9 TLARWXAADFSNqaqafen---ppfyahIRVCXRPLpwev---------------lsgVGFFVEQAYdyx---lndPYRL 67
                   90       100       110       120       130       140       150       160
           ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4TQ2_A 100 TVLVLykde--erkGKLLRSVGYteti---------------------pavGEWTMQe---DGTFVLHTfyd-------- 145
3BDR_A  88 TVLVPixdqgsrxeGKLLREXGYaeka---------------------pvaGRFSXGs---DGALTLITeye-------- 135
4O4O_A  68 RVLKLxiv---gdrIHIENYTVKqeenfygasrdlnrlqtltsesleklpgCNXIVEwtgnSFKGTVEPgkgcivvrkgq 144
4O4S_A  68 RVLKLxiv---gdrIHIENYTVKqeenfygasrdlnrlqtltsesleklpgCNXIVEwtgnSFKGTVEPgkgcivvrkgq 144
                  170       180       190       200
           ....*....|....*....|....*....|....*....|....
4TQ2_A 146 raAAEERIWFAtpdLRMRCSIIKtqhgkgvLTA---SLSTEVRD 186
3BDR_A 136 tiYSEERLWFAspnLRLRTSILKrfg--gfSXA---SFCSEIRL 174
4O4O_A 145 ktYLDSEFEINe-eKFISLDRGRdletdahIWGsvaGPFYFVRL 187
4O4S_A 145 ktYLDSEFEINe-eKFISLDRGRdletdahIWGsvaGPFYFVRL 187
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