2YB5,4ADO


Conserved Protein Domain Family
FusC_FusB

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cd16342: FusC_FusB 
Click on image for an interactive view with Cn3D
Fusidic acid resistance protein (FusC/FusB)
The fusidic acid resistance protein FusC (FusB) mediates resistance to the antibiotic fusidic acid. Its C-terminal domain, which contains a zinc-binding site, interacts with EF-G with high affinity, promoting the dissociation of stalled ribosome#EF-G#GDP complexes that form in the presence of fusidic acid, thus allowing the ribosomes to resume translation.
Statistics
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PSSM-Id: 319974
View PSSM: cd16342
Aligned: 151 rows
Threshold Bit Score: 183.074
Threshold Setting Gi: 982217738
Created: 29-Mar-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding sitedimer interface
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:The C-terminal domain contains a four-cysteine zinc finger with a unique structural fold
  • Structure:2YV5: Staphylococcus aureus fusidic acid resistance protein FusC binds Zinc
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2YB5_F         8 EVYKFVKVKQLVYQLIKLYRTn-DMNSHKTQKDFLLNEINDIFkekdiDISDFITSIDdvklTKKKAEHLLNELKVYiqd 86
gi 914622438   6 TNEKYNFIMKQAKQIAAAKHTvnDAGVKQAFIHSALDKVLALFpaigeEERGLLTKMVei-qSDVEMEQYQRTIEEYcip 84
gi 380317902   6 ENHVLNQILRQAKHVLDAEQRvnDMKVKQEFAYYSLNKAEKAFesltnPQLELLKPLVsi-kNEADFNHFKDSLEPYcip 84
gi 926244493   7 KNEQFNFISKQVAWIKDSTKQhlPAGVLASVYDLSNEKILNCIpnmtaSQKNILDFSKl--kTVEEYEQALEQLVNYllp 84
gi 749690137   7 RNEQYNYISKQVAAMRQSTKPhlTPAVRNSIIALSADRILSCIpgltaEQERLLDFTPy--kTIEEYDHGLSRLAAYrlp 84
gi 736776967   7 ENHQFNYIREQVETIRDSRKKslPSSVLQAVIDLANAKIAFLFpeatsAQLAMLDVSKl--qTDEAYDGFIDELRPHvrs 84
gi 670475629   7 QNEQYNLIKEQVMLVKESRMQslPPSVLRAVIDLAQAKVMYAFpeattEQLKLLQFTTl--qTNEAFDEYMQRLREWvqp 84
gi 902801148   6 ENHQYVFIREKARQIVHARHTvhDRHVQETFIDNSQFYVYEQFqtltdDQRECLNDLSei-rTEADYERFLSELVKWrip 84
gi 494382257   6 RNDQYNAIVQYVQVILDTKKKhvAPNVLKATIELAGAKILALFhestaEQQALLDVTAh--tTSEELHRFLEQLRSYvnp 83
gi 299815745  69 ENHTYNTIKKQAKQVLSANRTtnDKKLQKEFAYYILEKATALVse--kEQAELLQDILdl-kKEEEFLQFDDKLKAFvrp 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                               #  #     
2YB5_F        87 FEIPSSSQLEKIFRKVKKLKRPDinliDTKEIsYLGWNDNssNRKYIVYKNlddkFEGIYGEISPnKVKGFCKICNQESD 166
gi 914622438  85 FPELTDGKISKLFRKVKKLNHPPfteeDRKHLtYASWIDKgtGRKFIIRELdg-tIVGIHGRFLPsSKKGICHFCNHHSQ 163
gi 380317902  85 FQPITEAQLKKLFKKAKKLHPPHltpdDFLHLtYLSWYDKgsMKKFIVRELgg-sVKGLSGSFVPsPQNGICHFCHHMGA 163
gi 926244493  85 FPTVTEQQLKKLFPKSKKLKLPDlsnvDLKRLtYLSWNDSrsNKKYLLYELeg-qLVGIECTFSPsTKKNICSICHCHGE 163
gi 749690137  85 FPEVTDPQLKKLFPKRKKLKLPDltefDLEQTtYLGWNDSrsNRKYLLYILdg-rLEGLECSYSPnILHNTCSICHQQGP 163
gi 736776967  85 FPQVSEQQVKKMFPKQKKLRLPDaaelNVNRMsYMSWNDLrsNRKYILCEKnh-qLIGIELKASSnAKKNICAFCNQLAE 163
gi 670475629  85 FPVISAEQLKSLFPKQKKLRLPElsdvDFGRLtYLGWNDGrsNQKLMICQYeg-qLIGIACKPSTnTKKNICAFCNQFTD 163
gi 902801148  85 FPALSDAQLTKLFRKVKKLQYPLlpqeQMEELtYFGWTHN--ERKFIVKAVdg-sLRGISGRITPsSKQGLCHFCHKQAE 161
gi 494382257  84 FPPISEPQIKKLFPKAKKLKVPPldsvDWHKLtYLSWNDLgsNKKYIVYPQdg-kWLGIQCSLTPlAKAGYCSLCKCVND 162
gi 299815745 146 FPNIEEQKAKQLFKKIKKLHFPKa--sFPTRAtYISWFDNanNRKFMITERdg-kLAGLAGTFITnHKKSICHLCRQETE 222
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
Feature 1                                  #     #                
2YB5_F       167 TSLFLNKTKhnks--sgtYTKKGDYICYDSFKCNQNLDDINNLYEFIVK 213
gi 914622438 164 VGLYTVEMKskgn--sdqYKVLGNYICEDAAQCNQQLTSTDKLDEFLHQ 210
gi 380317902 164 VGLFTVDVKtdtk--nhnYKALSNYICQDEANCNAHITDTEKLDFLFDY 210
gi 926244493 164 VTHFSTVTKakklnnpdyYKSIGNLICVDSSQCNKNITDDSYLKDFLKE 212
gi 749690137 164 VTLVTTVTKerkannpdyYRTIGNFICTDSIACNRAITSTDYLERLFKE 212
gi 736776967 164 VSYCVTITKakqaknpdyYKAIGTYICTDSASCNENMTNLDALMTFVET 212
gi 670475629 164 VTYCVTITKakqaknpdyYKAIGTYVCVDSKTCNEHITSQEALHTFVHT 212
gi 902801148 162 VGLFSVERKvrgk--smnYQAFAHYICQDSMQCNQHLANVERIDAFMRE 208
gi 494382257 163 VSYVSTIAKkkqaknsdyYKALGNLICTDSATCNEKITTTMHVEKLFGD 211
gi 299815745 223 VGLFTIKGKvnak--tygYKAMGHYICTDSVACNEHLTDRANIDELFAF 269

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