1D1Q,1C0E,1D1P,1D1P,1D2A,1DG9,1P8A,1U2P,1XWW,2CWD,2GI4,2LUO,2P4U,3IDO,3JVI,3ROF,4ETM,4LRQ,4Z99,5PNT,2WMY,2FEK


Conserved Protein Domain Family
LMWPTP

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cd16343: LMWPTP 
Click on image for an interactive view with Cn3D
Low molecular weight protein tyrosine phosphatase
Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.
Statistics
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PSSM-Id: 319971
View PSSM: cd16343
Aligned: 553 rows
Threshold Bit Score: 129.865
Threshold Setting Gi: 938263212
Created: 18-Nov-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1D1Q; Saccharomyces cerevisiae low molecular weight protein-tyrosine phosphatase with bound 4 nitrophenylphosphate, contact 4 A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              ########                               #                                  
1D1Q_A         8 ISVAFIALGNFCRSPMAEAIFKHEvekanlenrfnKIDSFGTSNYHvge---spDHRTVSICKQHGVKIn-hKGKQIKTK 83
gi 383802511   2 KKILFVCMGNICRSPAAEGVMKSLvnqng-lkdkvFIDSAGTIEYHage---lpDLRMIEAAAERGYELn-hKARQITKS 76
gi 693438247   2 NKICFVCLGNICRSPMAEFVMKNLaqkyg-lndklNITSAGTAGYHdge---dmDKRTKKKLSEKGINAthfISKKLTQK 77
gi 770475790   3 LRILTVCTGNICRSPVAAALLRALrp-------daVLASAGLAAEPgr----saDPLTAEVALGLGIDLsghRARRFSAA 71
gi 972250753   3 DKILVICAGNICRSPYAARRLQRLmp-------ahTVHSAGLLTEKsglvgasvATEAQEVAGTLGLDLtdhRAQQITIA 75
gi 486372163   3 NHILVVCTGNICRSPIAEALLKKLlp-------elVIESAGTAVTKsnitdataHPYSQQVCNENGLDIfnhNARQLTPE 75
gi 827524705   3 DSILLVCTANICRSPIAEALFRHHfp-------nkRIFSAGTKVEAlnlidvpaDKGSIQATKWNGLDIsdhRATQVTSE 75
gi 922824407   3 NSILIVCTANICRSPMAEVIFRKLlp-------nhTICSAGTCVSTlnfddmpaDKNARLVAQQFELDLeqhRAQQLTPE 75
gi 741155681   3 KRVLVVCSGNICRSPLAQVLLSRLlp-------niSIDSAGVLVDHhdlsahpaVNNSRVVAKENGLDLsnhKAKQLTSE 75
gi 719406626   2 NNILIVCSGNICRSPIAHALFEKHmp-------slNIDSAGVFVDRhqlsgvhpVTNSQSVAKQNGLDIsrlQAQQLTPE 74
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                                                          # #                       
1D1Q_A        84 hfdeYDYIIGMDeSNINNLKkiqpe-gskaKVCLFgdwntndgtvqtiIEDPWYgdiqDFEYNFKQITYFSKQFLK 158
gi 383802511  77 dlenFDYIITMDdHIHKSVKhldsqkkfqnKIYKMtdflte--mkadeIPDPYYgdksDFEYSLDLIEDAAKGLLK 150
gi 693438247  78 lcdeSKLLLVMDkMNYKAVQsnfk--glenKLFYLldfce---ntekeIPDPYYt--nTFEECHELILKACEGLCK 146
gi 770475790  72 mgreTDLILAMApRHCEDIVriap--eltgRTFLLdhwc-----gaigIPDPYGkpraCHESVVDAILRATESWAE 140
gi 972250753  76 mvdsCDLILAMN-QNQIDILsrmfp-karhKAMLFghwl-----gvsqIDDPYQkssaVFQQVYAVLDRAARAWAD 144
gi 486372163  76 lcdrFDLILVMShEHIEEVAlvsp--gsrgKTMLIgqwi-----glgdIADPILepkaSFDTLYHTLVRATNTWAK 144
gi 827524705  76 llenSDLILVMDeTQKECLSryss--gvrsKTLLIgqwi-----nigeVADPYGksdeAFDVCFRCLEQAVLSWKK 144
gi 922824407  76 lidqYDLVLVMNrHQLEEVAevtr--garsKTLLIgqwi-----qlgdIADPYGkgltEFEQCYKTLARAALSWSK 144
gi 741155681  76 liddCDLILVMThEHLEQVAqlgr--garaKALLLgqwi-----gageIEDPIGkdidAFRQSYELLEKACLSWSK 144
gi 719406626  75 lvsqHDLILVMThEHIEQVAqvsq--garaKTLLIgqwi-----gvgeVHDPIGqemeVFEQCFSVLERAVLSWKS 143

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