1JL3,1JF8,1JFV,1LJL,1LJU,1LK0,1RXE,1Y1L,2CD7,2IPA,2L17,2L19,2MYU,3T38


Conserved Protein Domain Family
LMWP_ArsC

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cd16345: LMWP_ArsC 
Click on image for an interactive view with Cn3D
Arsenate reductase of the LMWP family
Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).
Statistics
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PSSM-Id: 319973
View PSSM: cd16345
Aligned: 235 rows
Threshold Bit Score: 123.713
Threshold Setting Gi: 56967337
Created: 18-Nov-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1RXE; Staphylococcus aureus arsenate reductase with bound phosphate in active site
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             # ######                                                                   
1JL3_A         5 IIYFLCTGNSCRSQMAEGWAKQYLgd-ewKVYSAGIeah-glNPNAVKAMKEVGIDIsnqTSDIIDsdi---lnnADLVV 79
1RXE_A         5 TIYFISTGNSARSQMAEGWGKEILge-gwNVYSAGIeth-gvNPKAIEAMKEVDIDIsnhTSDLIDndi---lkqSDLVV 79
gi 163846897 108 KVAFLCRANSARSQIAEAWLRVLSdg-qvQAMSAGThpq-avHPLAITVMAEVGIPIdqqVSKSITmii---dqrPDLIV 182
gi 746648063   6 HVLFLCTGNSARSIMAEAILNHYSgg-rfHAYSAGSrpkglvHPLALETLQFHGISIdglRSKPLTeflqanapaIDYVV 84
gi 939564523 119 RVLFLCTHNSARSQMAEGILRHFAgs-rvEAFSAGSqps-avHPDAVQVLAAIGIDIsqqRSKHLDqfa---dqsFDYII 193
gi 328770440   3 SVLFLCTHNSARSQIAEAILRHLDttgkfEAYSAGSeet-fvRPLAIKVMQEWNVDMsshTSKTLEqfl---drkIDFVV 78
gi 459672559   3 KVLFLCTGNSVRSIISECLLNQLGhn-nfQAYSAGSkptgkvNPYTIKVLEKNNINYkntLSKSWDtfi---dtkFDTVV 78
gi 297553018 117 RVLFLCTENSARSQMAEALLRQESqg-mvEAYSAGSqpaahiHPLTRRVMEQMGIDMsqaTPKPLHlfe---gqhFDAIV 192
gi 575458678   9 RVLVLCTGNSARSQIAEALLAVRGag-rvAAASAGSrpaarvNPYAVEVLRDHGIAWegrTPKSIDdva---eerFDLVI 84
gi 945506023   7 NVLFLSTQNTARSIMAEAMLNAVGgg-rfRAFSAGSqpagklNLFAVEQIRALDDSLnglRSKSLDefsepgapeMDFVI 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                                  # #                             
1JL3_A        80 TLCGdaa-dkCPmtpphVKREHWGFDDPARaqgteeekwaFFQRVRDEIGNRLKEFAE 136
1RXE_A        80 TLSSdad-nnCPilppnVKKEHWGFDDPAGke------wsEFQRVRDEIKLAIEKFKL 130
gi 163846897 183 TVCDiar-eeCPvwpeaARHIHWSVADPVAiqgtadqrhaAFVAAREELRERVRGLLA 239
gi 746648063  85 TVCSsaakeaCPlfpkkAIIEHWDLPDPAAvegdigkqkeAFQKIFDALHQRIFLYFL 142
gi 939564523 194 TVCDrvr-evCPvfpddPECIHWSFADPAAvedaa-arehAFQQTAQQLLTRVRYLLS 249
gi 328770440  79 TVCDsan-dtCPifpraIKKLHWSFPDPSKavg----tedEQLQAYRTVRNGLAERIT 131
gi 459672559  79 TVCNraanetCPvypgsPKKLHWELEDPAAfngndeeklnEFQRIFDQIHERIKKEFI 136
gi 297553018 193 TVCDrvr-evCPtfsddPERIHWSFPDPATvqgteaeqlhTFEQTALQLTTRIRSFLP 249
gi 575458678  85 TVCDnar-daCPhfpgaTAQVHWGLPDPAEavgal-aarrAFRETYDALAARVDALLA 140
gi 945506023  86 TMCDvaagepCPvwpgqPASANWNFRDPAArqgpvdgirqEFFTVCREIKTRLEIFRN 143

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