3LHO


Conserved Protein Domain Family
VOC_like

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cd16350: VOC_like 
Click on image for an interactive view with Cn3D
uncharacterized subfamily of the vicinal oxygen chelate (VOC) family
The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.
Statistics
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PSSM-Id: 319960
View PSSM: cd16350
Aligned: 90 rows
Threshold Bit Score: 231.659
Threshold Setting Gi: 693497290
Created: 7-Dec-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
metal binding
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: metal binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:H H T EClick to see conserved feature residue pattern help
Evidence:
  • Structure:3LHO: Shewanella frigidimarina putative hydrolase binds Ni(2+)
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                          #                             
3LHO_A         6 VNALFAALWQDYikxTPSAAKIHQLLGH---------------GAPIINDHIALRTFNIAk--------VNLSVLAKHFT 62
gi 750168464   4 LQKIFDGLMERYkadVPDVSKITKAMVDqyi---------iqnQFDIENDHVAFRTIGIPk--------LGIKAFEKIFL 66
gi 384069923  59 LQTVLSGLMRRYterVPDVQRIIDAMIDadm---------idsAADIENDHIAFRTMGVPn--------LGIASFEKIFL 121
gi 655009904  11 FEQVLDGLMRRYrerVPDVTAIAHAMVAegi---------iatPDQIENDHIAFRTMGVPh--------LGIRSLEKIFL 73
gi 502944129  10 LQGVLDGLMRRYkarVPDVEAILQAMTAegi---------irtPEEIENDHIAFRTMGVPh--------LGIASLEKVFL 72
gi 654844292   9 WEKVLDGLMGRYrqrVPDVGAIIAAMKTegi---------idsEKEIENDHIAFRSLGVPh--------LGIASMEKIFL 71
gi 652520735   9 LNELLNSLIIPYkerVPDVYRIINGMLEkgm---------iskEEDIINDHIAFRTLGLPy--------LGITSLEKIFL 71
gi 693497290  22 AKRSIAELVRGYfahNASARTACEHLMRvsgetmenltdaeyvARETPLDHLAFRSLGTKdmgidgvceRFEACGYVLCE 101
gi 406938876   6 RQHIIKNLWERYhvtTPHIKIIEEALARk-------------nISPLALDHFAIIDLPGLh--------SGIPQLKDIFT 64
gi 498283287   6 ADRVFSALWQNYcldYPLASLIYETIQTq-------------yNTVIPWDHVAFIDLPGPh--------TGRIPLIELWQ 64
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
3LHO_A        63 SIGYVDSGDYKFEQKKLIAKHFEHPDp-------KQPKVFISELLVEEFSPEVQKSIHGLIDQVDia------------- 122
gi 750168464  67 NYGYKARDRYNFESKKLNARWYASPTn-------KFPRVFISELRIHEFPKNIQELILKYTNEITndpike--------- 130
gi 384069923 122 ALGYEKRDPYQFVEKKLNAWWYAPPAldgp-hggNLPRIFVSELRVDDLSTTAQAIIHKYTDTVTadpvda--------- 191
gi 655009904  74 HYGYERRDHYHFPAKKLDAFWYHPPRp-------DLPRIFISELRVNDLSPEAAAIIRSYTDEVTadpvdt--------- 137
gi 502944129  73 HYGYRRRDAYDFPAKKLDAYWYSPPEp-------RFPRVFISELRVGELSPEAQRIIHAYTDEVTrdpvda--------- 136
gi 654844292  72 YYGYERRNFYQFDEKKLDAYWYSPPRe-------DLPRIFLSELRVQDLSDKARQVIHRYTDVVQhdpvds--------- 135
gi 652520735  72 HYGYEKRDYYFFPEKKLNAFWYSHPEn-------KYPRIFISELRVSDLSQNAQKIIQKYTKNINsdpvdn--------- 135
gi 693497290 102 ESEDGPAATYRFPEKRVRARWMRPPEtpi--geiALPRIFVSELVLEECDADLRSLVEGVLARVSdgk------------ 167
gi 406938876  65 LLGYETRGQGYLPDKQNDFVWLAEKNsaqqladqVLPQVVVADFRLHELPSEIKKIIEKYAQQTQhspqeeirdflt-sl 143
gi 498283287  65 SIDYEVRGQGYLAEKQNPFVWLAEKNqaqrlakqAWPQVVVADFYRAALAPKVRAIVDYYAAFARpldrqklyalkkral 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                           # #                          
3LHO_A       123 --------atTADNFIYSGRHWd-VDKATYQALLAESEYAAWVAALGYRANHFTVSINDlpe------ferIEDVNQALK 187
gi 750168464 131 ----ldlnnpEQVDDFLHTPLWsvPSWEDYQSLLKVSEYAAWVIYNRYYLNHYTIAVSSlpkg-----fntLESFNDFLN 201
gi 384069923 192 ----ldltdgAAIDAFLHQPLWptPTLADYQTLLAESEYAAWVIYNRYYLNHFTISVHNlpeg-----ynrIDEFVGFLQ 262
gi 655009904 138 ----ldlndaAQVDDFLHRPLWrlPTWADYQRLAAESEYAAWVIYNRYYLNHFTITVHNlptg-----yntIADFNAFLE 208
gi 502944129 137 ----ldlddaGAVDAFLHHPLWrlPSYADYRRLAEESEYAAWVIYNRYYLNHFTISVHNlpeg-----yntVEQFNAFLE 207
gi 654844292 136 ----ldledpMAVDAFLHTAQWpvPTWEDYRALANESEYAAWVIYNRYYLNHYTLAVHHfkqg-----yntIPEFNNFLE 206
gi 652520735 136 ----idfknvSEVSDFFTSALWelPTLDDYQSLLEESEYAAWVIYNRYYLNHFTISIHDlped-----ynrLEKFNDFLK 206
gi 693497290 168 -------vfqSGEYADGRIARWqlPAASTYAKLQKLSEYASWTLLHGYAVNHIAVSLFQlrkkypetpiraLEDVDKAFA 240
gi 406938876 144 ndanvskkiiDIILNYFCGRDWplPTINEFRAVQEFNELLAWVLIFGRRPNHFTISVHLhpy------fndLEHFNEFIK 217
gi 498283287 145 enkecaeewvTFMIDYLKGRDWplPTVEEFTFVKQHNELLAWVLVMGRQVNHFGLAIHLieh------fssLQVFNEWIQ 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                             #          
3LHO_A       188 QAGFVlns----sggEVKGSPEVLLEQSSTXADKVVVNFTD------------------GDVEIPSCFYEFARRYPXa-- 243
gi 750168464 202 SLGILlsd----aggYIKESPDKLLLQSATVSQLKKAIFAAg-----------------DSHLIAGSYVEFAERKILpey 260
gi 384069923 263 DRGIRlns----sggVVKVSPDGGLRQASTVAQLVEAEFTNg-----------------DTQRIAGSYVEFAERRVLpef 321
gi 655009904 209 RHGFKlnd----aggKIKVSPDGKLLQSSTVAEMIWAEFAGg-----------------ERHQIAGSYVEFAERRPLdef 267
gi 502944129 208 ARGFTlna----aggKAKRSPDGLLIQSSTVAEMIEAEFAGg-----------------ERHKIAGSYVEFAERRPLpef 266
gi 654844292 207 RHGFKlnd----aggKVKQSPDGGLLQSSTVAGKVEASFADg-----------------RKEWIPGSYVEFAERRVLepy 265
gi 652520735 207 SIEIKlnn----sggEIKESRDGLLKQSSSVAGKVRANFLGs-----------------EVIEIPGSYVEFAQRLVLpef 265
gi 693497290 241 ANAALarkpwndrggRIKRSPSGLLLQSSLMSEPHRFNLYKqtqairnrygrddeeeifKEYKLPGSYIEFVQRMPRpeh 320
gi 406938876 218 TEAKLalnp---dggIIKGGKHTGIAQSSTLGISETVSLAD------------------GNIDIPTGFVEFVWRYSNvsn 276
gi 498283287 219 ATLAIplnq---eggLIKGGAQQEIAQSSTAAIKKNVRLAD------------------GPSQLADRFIEFVWRYPKknn 277
                        330       340
                 ....*....|....*....|..
Feature 1                              
3LHO_A       244 ---------NGQLYTGFVAASA 256
gi 750168464 261 qhiplaeieRKHRKEGFEAANA 282
gi 384069923 322 anvpsdqltRAHRREGFEAGNA 343
gi 655009904 268 ahlpphelrREHRREGFEAGNA 289
gi 502944129 267 ag--qteltREQRREGFEAGNA 286
gi 654844292 266 rhlppdqvkREYRREGFEAQNA 287
gi 652520735 266 sdlplskikKDHRRDGFETGNA 287
gi 693497290 321 adkafeelnEQDLRDGFESSNA 342
gi 406938876 277 k-----pnlWSDYFTGFIATHA 293
gi 498283287 278 ed---ksllWSAYFTDFIAKQA 296

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