3SFT,1CHD


Conserved Protein Domain Family
CheB_like

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cd16351: CheB_like 
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methylesterase CheB domain family
This family contains the methylesterase CheB (EC 3.1.1.61; also known as CheB methylesterase, chemotaxis-specific methylesterase, methyl-accepting chemotaxis protein methyl-esterase, or protein methyl-esterase) domain, a phosphorylation-activated response regulator involved in reversible modification of bacterial chemotaxis receptors. Signaling output of the chemotaxis receptors is modulated by CheB and methyltransferase CheR by controlling the level of receptor methylation. CheB family members may also contain an N-terminal regulatory (REC) domain, which blocks the active site of the C-terminal domain until it is phosphorylated, or a CheR domain; typically cheB and cheR occur in the same operon. Reversible methylation of transmembrane chemoreceptors plays an important role in ligand-dependent signaling and cellular adaptation in bacterial chemotaxis. Phosphorylated CheB catalyzes deamidation of specific glutamine residues in the cytoplasmic region of the chemoreceptors and demethylation of specific methyl glutamate residues introduced into the chemoreceptors by CheR.
Statistics
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PSSM-Id: 319750
View PSSM: cd16351
Aligned: 3 rows
Threshold Bit Score: 308.726
Threshold Setting Gi: 568810871
Created: 28-Mar-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3SFT_A          9 IVVIGSStggPRSLDMIIPNLPKNfpaPIVVVQHMPpgFTKSLAMRLDStseLTVKEAEDgEEVKpGFVYIAPGdfHLGL 88
1CHD_A         12 LIAIGAStggTEAIRHVLQPLPLSs-pAVIITQHMPpgFTRSFAERLNKlcqISVKEAEDgERVLpGHAYIAPGdkHMEL 90
gi 568810871   23 IVGVGASagsLEALEHLFEQVNIHsglVYVVIQHLSpkFKSYMHELLGKktkVGIKHIKDdMPIEiDTIYLAPPrtFINI 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3SFT_A         89 KaqngkvFFFLDKSdkinnvRPAVDFTLDKAAEiyksKTIAVILTGmgkDGTKGAFKVKFyGGTVIAEDKetcvvfGMPK 168
1CHD_A         91 ArsganyQIKIHDGppvnrhRPSVDVLFHSVAKhagrNAVGVILTGmgnDGAAGMLAMYQaGAWTIAQNEascvvfGMPR 170
gi 568810871  103 Engk-fkVQELSNDtg---lTYPIDHFFSSLAKynkeKSIAVVLSGkgnDGSSGLSYVYDtGGTVIVQTEesakfmEMPN 178
                         170       180
                  ....*....|....*....|....
3SFT_A        169 SVIEEGyadYVLPaykIPEKLIEL 192
1CHD_A        171 EAINMGgvsEVVDlsqVSQQMLAK 194
gi 568810871  179 YAIQTGkvdHVVRpeeMASLFEQI 202
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