Conserved Protein Domain Family
VOC_like

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cd16355: VOC_like 
uncharacterized subfamily of vicinal oxygen chelate (VOC) superfamily
The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.
Statistics
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PSSM-Id: 319962
View PSSM: cd16355
Aligned: 11 rows
Threshold Bit Score: 134.927
Threshold Setting Gi: 497488977
Created: 29-Dec-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #### #               ###                   #                      ### #         
gi 497488977   8 TEHVLAVPDLARSVRWWRE-AMGFQTVfe-----------tPGWVFMALggar----------lrlGECPDAlpahalgd 65
gi 952931163   6 ITPILNVSDIQRSFDWFEK-LGWKKCWdwgapptfgsvgsgECEIFLCVnaqggrgdgenrpsfgpDSNGAAe------- 77
gi 737231872   6 VTPILNVSDMAASFAWFER-WGWKKLWdwgtppsfgavgsgGAEIFLCLggqggrgk--ganastfGPDGDEvs------ 76
gi 498273692   6 LTPILNVSNIQQSFEWFEK-LGWSKGWdwgvpptfggvcsgPCEIFLCEnaqggrgk--sdlkttfGPEGSDaa------ 76
gi 493560462   6 ITPILNVSSLQESFGWFEK-LGWQKLWdwgdppgfgavgsgECEIFLCQdgqggrgk--gnnsstfGPGGDEtq------ 76
gi 836675739   6 LTPILNVSNIEQSFTWFQK-LGWTKGLewgqpitfgsvysgPCEVFLCQggqggrga--sgfpatfGPNSDEsa------ 76
gi 72121240   29 YAYVLAVPDLPRSAAYFENaLGFSTDWq-------------DGDNWRALsrgsv--------rvmlGHCPDAlppsqtgd 87
gi 699013647   1 MVPVLNVRNVPAAIAYYRDkLGFRLDWewgdppgfacidrgPVRIFLCQ-----------------GAQGAP-------- 55
gi 952929770  10 CAYVLAVPDAEATARWWQTmFGFERWL--------------EPQGWVFVrrgac--------dlrlGSCPDAlaph---e 64
gi 501119165  17 LSPILNVSSIPTSIDYYVNvLGFQKDWdwgdpptfasvsrdDVCIFLCQ-----------------GAQGQP-------- 71
gi 496151045   6 TSFVLAVPDAGATAKWWVDvMGFARVL--------------EPEGWVFVqrdec--------lirlGSCPDAipprdlgd 63
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
Feature 1             ######     ##  #                                 #   
gi 497488977  66 hsyFAFFHVTD---IDALAEHLRVKG-ATIRsGPADQPWGLREMAVESPDGHRFMLGQ 119
gi 952931163  78 --tGVWMSIWVd-dVDAVHQRCIEQG-IEISwGPENMPWGVREMHVRHPDGHVFRISR 131
gi 737231872  77 -dkGAWMSIWVd-dVDEVHRQCVAAG-LDVTfPPTDMPWRVREMHVRHPDGHVFRVSK 131
gi 498273692  77 -ekGVWMSIWVd-dVDAVHQRCLDQH-LDVTwPPTDMPWGVREMHVRHPDGHVFRISR 131
gi 493560462  77 -dkGAWMSIWVe-nVDQVYALAIENG-IEVVfPPEDMPWKARECHLRHPDGHVFRVSQ 131
gi 836675739  77 -ekGVWMSVWVe-dLDTLHQHCLNND-IEVTwPPTDMPWNVREMHVRHPDGHVFRVSC 131
gi 72121240   88 hsyFAYFHVDD---IDALHAELASRG-AIIAqPPADKPWGMREMALATPDGHRMMVGQ 141
gi 699013647  56 ---GMWLCVNVd-dVDALHREYQASG-AIIRqPPTNFPWGMREMNVEDLDGHRLRIGS 108
gi 952929770  65 tgdHNYFGVVLvdaIDALFEEARARGlSSLA-PPQDQPWGMREMIVQTPDGHRLVFAQ 121
gi 501119165  72 ---GTWISIFVa-dVDALFIDYKAKG-AKIRqAPTNFSWGMREMNIEDPDGHRLRVGS 124
gi 496151045  64 hqyFGYVEVDA---IDLFHRDISERG-ADILfPPTTQPWDMREMGVRTPDGHRVMFAQ 117

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